1f5q
From Proteopedia
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| - | [[Image:1f5q.gif|left|200px]] | + | [[Image:1f5q.gif|left|200px]] |
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| - | '''CRYSTAL STRUCTURE OF MURINE GAMMA HERPESVIRUS CYCLIN COMPLEXED TO HUMAN CYCLIN DEPENDENT KINASE 2''' | + | {{Structure |
| + | |PDB= 1f5q |SIZE=350|CAPTION= <scene name='initialview01'>1f5q</scene>, resolution 2.50Å | ||
| + | |SITE= | ||
| + | |LIGAND= <scene name='pdbligand=CL:CHLORIDE ION'>CL</scene> | ||
| + | |ACTIVITY= | ||
| + | |GENE= | ||
| + | }} | ||
| + | |||
| + | '''CRYSTAL STRUCTURE OF MURINE GAMMA HERPESVIRUS CYCLIN COMPLEXED TO HUMAN CYCLIN DEPENDENT KINASE 2''' | ||
| + | |||
==Overview== | ==Overview== | ||
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==About this Structure== | ==About this Structure== | ||
| - | 1F5Q is a [ | + | 1F5Q is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [http://en.wikipedia.org/wiki/Murid_herpesvirus_1 Murid herpesvirus 1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1F5Q OCA]. |
==Reference== | ==Reference== | ||
| - | Crystal structure of a gamma-herpesvirus cyclin-cdk complex., Card GL, Knowles P, Laman H, Jones N, McDonald NQ, EMBO J. 2000 Jun 15;19(12):2877-88. PMID:[http:// | + | Crystal structure of a gamma-herpesvirus cyclin-cdk complex., Card GL, Knowles P, Laman H, Jones N, McDonald NQ, EMBO J. 2000 Jun 15;19(12):2877-88. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/10856233 10856233] |
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Murid herpesvirus 1]] | [[Category: Murid herpesvirus 1]] | ||
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[[Category: herpesviral cyclin]] | [[Category: herpesviral cyclin]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 11:04:50 2008'' |
Revision as of 09:04, 20 March 2008
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| , resolution 2.50Å | |||||||
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| Coordinates: | save as pdb, mmCIF, xml | ||||||
CRYSTAL STRUCTURE OF MURINE GAMMA HERPESVIRUS CYCLIN COMPLEXED TO HUMAN CYCLIN DEPENDENT KINASE 2
Overview
Several gamma-herpesviruses encode proteins related to the mammalian cyclins, regulatory subunits of cyclin-dependent kinases (cdks) essential for cell cycle progression. We report a 2.5 A crystal structure of a full-length oncogenic viral cyclin from gamma-herpesvirus 68 complexed with cdk2. The viral cyclin binds cdk2 with an orientation different from cyclin A and makes several novel interactions at the interface, yet it activates cdk2 by triggering conformational changes similar to cyclin A. Sequences within the viral cyclin N-terminus lock part of the cdk2 T-loop within the core of the complex. These sequences and others are conserved amongst the viral and cellular D-type cyclins, suggesting that this structure has wider implications for other cyclin-cdk complexes. The observed resistance of this viral cyclin-cdk complex to inhibition by the p27(KIP:) cdk inhibitor is explained by sequence and conformational variation in the cyclin rendering the p27(KIP:)-binding site on the cyclin subunit non-functional.
About this Structure
1F5Q is a Protein complex structure of sequences from Homo sapiens and Murid herpesvirus 1. Full crystallographic information is available from OCA.
Reference
Crystal structure of a gamma-herpesvirus cyclin-cdk complex., Card GL, Knowles P, Laman H, Jones N, McDonald NQ, EMBO J. 2000 Jun 15;19(12):2877-88. PMID:10856233
Page seeded by OCA on Thu Mar 20 11:04:50 2008
