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1fb8

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[[Image:1fb8.gif|left|200px]]<br /><applet load="1fb8" size="350" color="white" frame="true" align="right" spinBox="true"
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[[Image:1fb8.gif|left|200px]]
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caption="1fb8, resolution 2.40&Aring;" />
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'''STRUCTURE OF THE PLECKSTRIN HOMOLOGY DOMAIN FROM DAPP1/PHISH'''<br />
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{{Structure
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|PDB= 1fb8 |SIZE=350|CAPTION= <scene name='initialview01'>1fb8</scene>, resolution 2.40&Aring;
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|SITE=
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|LIGAND= <scene name='pdbligand=PO4:PHOSPHATE ION'>PO4</scene>
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|ACTIVITY=
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|GENE=
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}}
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'''STRUCTURE OF THE PLECKSTRIN HOMOLOGY DOMAIN FROM DAPP1/PHISH'''
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==Overview==
==Overview==
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==About this Structure==
==About this Structure==
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1FB8 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with <scene name='pdbligand=PO4:'>PO4</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1FB8 OCA].
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1FB8 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1FB8 OCA].
==Reference==
==Reference==
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Structural basis for discrimination of 3-phosphoinositides by pleckstrin homology domains., Ferguson KM, Kavran JM, Sankaran VG, Fournier E, Isakoff SJ, Skolnik EY, Lemmon MA, Mol Cell. 2000 Aug;6(2):373-84. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=10983984 10983984]
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Structural basis for discrimination of 3-phosphoinositides by pleckstrin homology domains., Ferguson KM, Kavran JM, Sankaran VG, Fournier E, Isakoff SJ, Skolnik EY, Lemmon MA, Mol Cell. 2000 Aug;6(2):373-84. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/10983984 10983984]
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Single protein]]
[[Category: Single protein]]
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[[Category: Skolnik, E Y.]]
[[Category: Skolnik, E Y.]]
[[Category: PO4]]
[[Category: PO4]]
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[[Category: 3-phosphoinositides]]
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[[Category: 3-phosphoinositide]]
[[Category: adaptor protein]]
[[Category: adaptor protein]]
[[Category: inositol tetrakisphosphate signal transduction protein]]
[[Category: inositol tetrakisphosphate signal transduction protein]]
[[Category: pleckstrin]]
[[Category: pleckstrin]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 12:36:56 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 11:06:50 2008''

Revision as of 09:06, 20 March 2008

Image:1fb8.gif


PDB ID 1fb8

Drag the structure with the mouse to rotate
, resolution 2.40Å
Ligands:
Coordinates: save as pdb, mmCIF, xml



STRUCTURE OF THE PLECKSTRIN HOMOLOGY DOMAIN FROM DAPP1/PHISH


Overview

Pleckstrin homology (PH) domains are protein modules of around 120 amino acids found in many proteins involved in cellular signaling. Certain PH domains drive signal-dependent membrane recruitment of their host proteins by binding strongly and specifically to lipid second messengers produced by agonist-stimulated phosphoinositide 3-kinases (PI 3-Ks). We describe X-ray crystal structures of two different PH domains bound to Ins(1,3,4,5)P4, the head group of the major PI 3-K product PtdIns(3,4,5)P3. One of these PH domains (from Grp1) is PtdIns(3,4,5)P3 specific, while the other (from DAPP1/PHISH) binds strongly to both PtdIns(3,4,5)P3 and its 5'-dephosphorylation product, PtdIns(3,4)P2. Comparison of the two structures provides an explanation for the distinct phosphoinositide specificities of the two PH domains and allows us to predict the 3-phosphoinositide selectivity of uncharacterized PH domains.

About this Structure

1FB8 is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Structural basis for discrimination of 3-phosphoinositides by pleckstrin homology domains., Ferguson KM, Kavran JM, Sankaran VG, Fournier E, Isakoff SJ, Skolnik EY, Lemmon MA, Mol Cell. 2000 Aug;6(2):373-84. PMID:10983984

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