1lp3

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[[Image:1lp3.png|left|200px]]
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==The Atomic Structure of Adeno-Associated Virus (AAV-2), a Vector for Human Gene Therapy==
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<StructureSection load='1lp3' size='340' side='right' caption='[[1lp3]], [[Resolution|resolution]] 3.00&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1lp3]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Adeno-associated_virus_-_2 Adeno-associated virus - 2]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1LP3 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1LP3 FirstGlance]. <br>
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</td></tr><tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1lp3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1lp3 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1lp3 RCSB], [http://www.ebi.ac.uk/pdbsum/1lp3 PDBsum]</span></td></tr>
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<table>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/lp/1lp3_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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The structure of the adeno-associated virus (AAV-2) has been determined to 3-A resolution by x-ray crystallography. AAV is being developed as a vector for gene therapy to treat diseases including hemophilia, cancer, and cystic fibrosis. As in the distantly related autonomous parvoviruses, the capsid protein has a beta-barrel fold, but long loops between the beta-strands share little structural homology with other parvoviruses, leading to unique surface features. Most prominent are groups of threefold-related peaks, each an intimate association of loops from two neighboring subunits. Mutations affecting cell entry and receptor binding are clustered near the positively charged side of each peak, implicating the region in attachment to the cellular receptor, heparan sulfate proteoglycan. Amino acids involved in antibody binding are in the same general vicinity. The structure will guide rational engineering of vector capsids to tailor cellular targeting and to avoid immediate neutralization by an immune system sensitized by prior exposure to AAV.
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{{STRUCTURE_1lp3| PDB=1lp3 | SCENE= }}
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The atomic structure of adeno-associated virus (AAV-2), a vector for human gene therapy.,Xie Q, Bu W, Bhatia S, Hare J, Somasundaram T, Azzi A, Chapman MS Proc Natl Acad Sci U S A. 2002 Aug 6;99(16):10405-10. Epub 2002 Jul 22. PMID:12136130<ref>PMID:12136130</ref>
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===The Atomic Structure of Adeno-Associated Virus (AAV-2), a Vector for Human Gene Therapy===
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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{{ABSTRACT_PUBMED_12136130}}
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==About this Structure==
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[[1lp3]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Adeno-associated_virus_-_2 Adeno-associated virus - 2]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1LP3 OCA].
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==See Also==
==See Also==
*[[Virus coat protein|Virus coat protein]]
*[[Virus coat protein|Virus coat protein]]
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== References ==
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==Reference==
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<references/>
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<ref group="xtra">PMID:012136130</ref><ref group="xtra">PMID:012777756</ref><references group="xtra"/>
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__TOC__
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</StructureSection>
[[Category: Adeno-associated virus - 2]]
[[Category: Adeno-associated virus - 2]]
[[Category: Azzi, A.]]
[[Category: Azzi, A.]]

Revision as of 17:05, 28 September 2014

The Atomic Structure of Adeno-Associated Virus (AAV-2), a Vector for Human Gene Therapy

1lp3, resolution 3.00Å

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