2vev

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[[Image:2vev.png|left|200px]]
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==CRYSTAL STRUCUTRE OF PROTEIN TYROSINE PHOSPHATASE 1B IN COMPLEX WITH AN ISOTHIAZOLIDINONE-CONTAINING INHIBITOR==
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<StructureSection load='2vev' size='340' side='right' caption='[[2vev]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[2vev]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VEV OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2VEV FirstGlance]. <br>
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</td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=IZ2:N-[(1S)-1-(4-BENZYL-1H-IMIDAZOL-2-YL)-2-{4-[(5S)-1,1-DIOXIDO-3-OXOISOTHIAZOLIDIN-5-YL]PHENYL}ETHYL]-3-(TRIFLUOROMETHYL)BENZENESULFONAMIDE'>IZ2</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene><br>
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<tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1bzc|1bzc]], [[1c83|1c83]], [[1g1g|1g1g]], [[1g1h|1g1h]], [[1i57|1i57]], [[1jf7|1jf7]], [[1kak|1kak]], [[1kav|1kav]], [[1nl9|1nl9]], [[1nny|1nny]], [[1nwl|1nwl]], [[1nz7|1nz7]], [[1oeo|1oeo]], [[1oev|1oev]], [[1ony|1ony]], [[1pa1|1pa1]], [[1pty|1pty]], [[1pxh|1pxh]], [[1q1m|1q1m]], [[1q6j|1q6j]], [[1sug|1sug]], [[1a5y|1a5y]], [[1aax|1aax]], [[1bzh|1bzh]], [[1bzj|1bzj]], [[1c84|1c84]], [[1c85|1c85]], [[1c86|1c86]], [[1c87|1c87]], [[1c88|1c88]], [[1ecv|1ecv]], [[1een|1een]], [[1eeo|1eeo]], [[1g1f|1g1f]], [[1g7f|1g7f]], [[1g7g|1g7g]], [[1gfy|1gfy]], [[1l8g|1l8g]], [[1lqf|1lqf]], [[1t48|1t48]], [[1t49|1t49]], [[1t4j|1t4j]], [[1xbo|1xbo]], [[2azr|2azr]], [[2bgd|2bgd]], [[2bge|2bge]], [[2cm2|2cm2]], [[2cm7|2cm7]], [[2cm8|2cm8]], [[2cma|2cma]], [[2cmb|2cmb]], [[2cnh|2cnh]], [[2cni|2cni]], [[2f6w|2f6w]], [[2f6y|2f6y]], [[2f70|2f70]], [[2hnq|2hnq]], [[1no6|1no6]], [[1nwe|1nwe]], [[1oem|1oem]], [[1oes|1oes]], [[1oet|1oet]], [[1oeu|1oeu]], [[1onz|1onz]], [[1ph0|1ph0]], [[1ptt|1ptt]], [[1ptu|1ptu]], [[1ptv|1ptv]], [[1pyn|1pyn]], [[1q6m|1q6m]], [[1q6n|1q6n]], [[1q6p|1q6p]], [[1q6s|1q6s]], [[1q6t|1q6t]], [[1qxk|1qxk]], [[1wax|1wax]], [[2b07|2b07]], [[2b4s|2b4s]], [[2cm3|2cm3]], [[2cmc|2cmc]], [[2cne|2cne]], [[2cnf|2cnf]], [[2cng|2cng]], [[2f6f|2f6f]], [[2f6t|2f6t]], [[2f6v|2f6v]], [[2f6z|2f6z]], [[2f71|2f71]], [[2fjm|2fjm]], [[2fjn|2fjn]], [[2hnp|2hnp]], [[2veu|2veu]], [[2vew|2vew]], [[2vex|2vex]], [[2vey|2vey]]</td></tr>
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<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Protein-tyrosine-phosphatase Protein-tyrosine-phosphatase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.3.48 3.1.3.48] </span></td></tr>
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<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2vev FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vev OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2vev RCSB], [http://www.ebi.ac.uk/pdbsum/2vev PDBsum]</span></td></tr>
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<table>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ve/2vev_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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The structure-based design and synthesis of isothiazolidinone (IZD) inhibitors of PTP1B containing imidazoles and imidazolines and their modification to interact with the B site of PTP1B are described here. The X-ray crystal structures of 3I and 4I complexed with PTP1B were solved and revealed the inhibitors are interacting extensively with the B site of the enzyme.
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{{STRUCTURE_2vev| PDB=2vev | SCENE= }}
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Isothiazolidinone inhibitors of PTP1B containing imidazoles and imidazolines.,Douty B, Wayland B, Ala PJ, Bower MJ, Pruitt J, Bostrom L, Wei M, Klabe R, Gonneville L, Wynn R, Burn TC, Liu PC, Combs AP, Yue EW Bioorg Med Chem Lett. 2008 Jan 1;18(1):66-71. Epub 2007 Nov 9. PMID:18037290<ref>PMID:18037290</ref>
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===CRYSTAL STRUCUTRE OF PROTEIN TYROSINE PHOSPHATASE 1B IN COMPLEX WITH AN ISOTHIAZOLIDINONE-CONTAINING INHIBITOR===
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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{{ABSTRACT_PUBMED_18037290}}
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==About this Structure==
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[[2vev]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VEV OCA].
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==See Also==
==See Also==
*[[Tyrosine phosphatase|Tyrosine phosphatase]]
*[[Tyrosine phosphatase|Tyrosine phosphatase]]
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== References ==
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==Reference==
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<references/>
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<ref group="xtra">PMID:018037290</ref><references group="xtra"/>
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Protein-tyrosine-phosphatase]]
[[Category: Protein-tyrosine-phosphatase]]

Revision as of 06:47, 29 September 2014

CRYSTAL STRUCUTRE OF PROTEIN TYROSINE PHOSPHATASE 1B IN COMPLEX WITH AN ISOTHIAZOLIDINONE-CONTAINING INHIBITOR

2vev, resolution 1.80Å

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Proteopedia Page Contributors and Editors (what is this?)

OCA

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