1gnd

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[[Image:1gnd.gif|left|200px]]<br /><applet load="1gnd" size="350" color="white" frame="true" align="right" spinBox="true"
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[[Image:1gnd.gif|left|200px]]
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caption="1gnd, resolution 1.81&Aring;" />
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'''GUANINE NUCLEOTIDE DISSOCIATION INHIBITOR, ALPHA-ISOFORM'''<br />
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{{Structure
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|PDB= 1gnd |SIZE=350|CAPTION= <scene name='initialview01'>1gnd</scene>, resolution 1.81&Aring;
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|SITE=
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|LIGAND=
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|ACTIVITY=
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|GENE= BOVGDI ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9913 Bos taurus])
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}}
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'''GUANINE NUCLEOTIDE DISSOCIATION INHIBITOR, ALPHA-ISOFORM'''
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==Overview==
==Overview==
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==About this Structure==
==About this Structure==
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1GND is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1GND OCA].
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1GND is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1GND OCA].
==Reference==
==Reference==
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Structure and mutational analysis of Rab GDP-dissociation inhibitor., Schalk I, Zeng K, Wu SK, Stura EA, Matteson J, Huang M, Tandon A, Wilson IA, Balch WE, Nature. 1996 May 2;381(6577):42-8. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=8609986 8609986]
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Structure and mutational analysis of Rab GDP-dissociation inhibitor., Schalk I, Zeng K, Wu SK, Stura EA, Matteson J, Huang M, Tandon A, Wilson IA, Balch WE, Nature. 1996 May 2;381(6577):42-8. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/8609986 8609986]
[[Category: Bos taurus]]
[[Category: Bos taurus]]
[[Category: Single protein]]
[[Category: Single protein]]
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[[Category: gtpase activation]]
[[Category: gtpase activation]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 12:51:54 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 11:25:23 2008''

Revision as of 09:25, 20 March 2008

Image:1gnd.gif


PDB ID 1gnd

Drag the structure with the mouse to rotate
, resolution 1.81Å
Gene: BOVGDI (Bos taurus)
Coordinates: save as pdb, mmCIF, xml



GUANINE NUCLEOTIDE DISSOCIATION INHIBITOR, ALPHA-ISOFORM


Overview

The crystal structure of the bovine alpha-isoform of Rab GDP-dissociation inhibitor (GDI), which functions in vesicle-membrane transport to recycle and regulate Rab GTPases, has been determined to a resolution of 1.81 A. GDI is constructed of two main structural units, a large complex multisheet domain I and a smaller alpha-helical domain II. The structural organization of domain I is surprisingly closely related to FAD-containing monooxygenases and oxidases. Sequence-conserved regions common to GDI and the choroideraemia gene product, which delivers Rab to catalytic subunits of Rab geranylgeranyltransferase II, are clustered on one face of the molecule. The two most sequence-conserved regions, which form a compact structure at the apex of GDI, are shown by site-directed mutagenesis to play a critical role in the binding of Rab proteins.

About this Structure

1GND is a Single protein structure of sequence from Bos taurus. Full crystallographic information is available from OCA.

Reference

Structure and mutational analysis of Rab GDP-dissociation inhibitor., Schalk I, Zeng K, Wu SK, Stura EA, Matteson J, Huang M, Tandon A, Wilson IA, Balch WE, Nature. 1996 May 2;381(6577):42-8. PMID:8609986

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