1gnu

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[[Image:1gnu.jpg|left|200px]]<br /><applet load="1gnu" size="350" color="white" frame="true" align="right" spinBox="true"
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[[Image:1gnu.jpg|left|200px]]
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caption="1gnu, resolution 1.75&Aring;" />
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'''GABA(A) RECEPTOR ASSOCIATED PROTEIN GABARAP'''<br />
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{{Structure
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|PDB= 1gnu |SIZE=350|CAPTION= <scene name='initialview01'>1gnu</scene>, resolution 1.75&Aring;
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|SITE= <scene name='pdbsite=NI:Ni+Binding+Site+For+Chain+A'>NI</scene>
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|LIGAND= <scene name='pdbligand=NI:NICKEL (II) ION'>NI</scene>
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|ACTIVITY=
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|GENE=
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}}
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'''GABA(A) RECEPTOR ASSOCIATED PROTEIN GABARAP'''
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==Overview==
==Overview==
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==About this Structure==
==About this Structure==
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1GNU is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with <scene name='pdbligand=NI:'>NI</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Known structural/functional Site: <scene name='pdbsite=NI:Ni+Binding+Site+For+Chain+A'>NI</scene>. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1GNU OCA].
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1GNU is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1GNU OCA].
==Reference==
==Reference==
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The X-ray crystal structure and putative ligand-derived peptide binding properties of gamma-aminobutyric acid receptor type A receptor-associated protein., Knight D, Harris R, McAlister MS, Phelan JP, Geddes S, Moss SJ, Driscoll PC, Keep NH, J Biol Chem. 2002 Feb 15;277(7):5556-61. Epub 2001 Nov 29. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=11729197 11729197]
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The X-ray crystal structure and putative ligand-derived peptide binding properties of gamma-aminobutyric acid receptor type A receptor-associated protein., Knight D, Harris R, McAlister MS, Phelan JP, Geddes S, Moss SJ, Driscoll PC, Keep NH, J Biol Chem. 2002 Feb 15;277(7):5556-61. Epub 2001 Nov 29. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/11729197 11729197]
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Single protein]]
[[Category: Single protein]]
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[[Category: ubiquitin-like]]
[[Category: ubiquitin-like]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 12:52:04 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 11:25:36 2008''

Revision as of 09:25, 20 March 2008

Image:1gnu.jpg


PDB ID 1gnu

Drag the structure with the mouse to rotate
, resolution 1.75Å
Sites:
Ligands:
Coordinates: save as pdb, mmCIF, xml



GABA(A) RECEPTOR ASSOCIATED PROTEIN GABARAP


Overview

The gamma-aminobutyric acid receptor type A (GABA(A)) receptor-associated protein (GABARAP) has been reported to mediate the interaction between the GABA(A) receptor and microtubules. We present the three-dimensional structure of GABARAP obtained by x-ray diffraction at 1.75 A resolution. The structure was determined by molecular replacement using the structure of the homologous protein GATE-16. NMR spectroscopy of isotope-labeled GABARAP showed the structure in solution to be compatible with the overall fold but showed evidence of conformation heterogeneity that is not apparent in the crystal structure. We assessed the binding of GABARAP to peptides derived from reported binding partner proteins, including the M3-M4 loop of the gamma2 subunit of the GABA(A) receptor and the acidic carboxyl-terminal tails of human alpha- and beta-tubulin. There is a small area of concentrated positive charge on one surface of GABARAP, which we found interacts weakly with all peptides tested, but we found no evidence for specific binding to the proposed physiological target peptides. These results are compatible with a more general role in membrane targeting and transportation for the GABARAP family of proteins.

About this Structure

1GNU is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

The X-ray crystal structure and putative ligand-derived peptide binding properties of gamma-aminobutyric acid receptor type A receptor-associated protein., Knight D, Harris R, McAlister MS, Phelan JP, Geddes S, Moss SJ, Driscoll PC, Keep NH, J Biol Chem. 2002 Feb 15;277(7):5556-61. Epub 2001 Nov 29. PMID:11729197

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