1h4l
From Proteopedia
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| - | [[Image:1h4l.gif|left|200px]] | + | [[Image:1h4l.gif|left|200px]] |
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| - | '''STRUCTURE AND REGULATION OF THE CDK5-P25(NCK5A) COMPLEX''' | + | {{Structure |
| + | |PDB= 1h4l |SIZE=350|CAPTION= <scene name='initialview01'>1h4l</scene>, resolution 2.65Å | ||
| + | |SITE= | ||
| + | |LIGAND= | ||
| + | |ACTIVITY= | ||
| + | |GENE= | ||
| + | }} | ||
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| + | '''STRUCTURE AND REGULATION OF THE CDK5-P25(NCK5A) COMPLEX''' | ||
| + | |||
==Overview== | ==Overview== | ||
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==About this Structure== | ==About this Structure== | ||
| - | 1H4L is a [ | + | 1H4L is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1H4L OCA]. |
==Reference== | ==Reference== | ||
| - | Structure and regulation of the CDK5-p25(nck5a) complex., Tarricone C, Dhavan R, Peng J, Areces LB, Tsai LH, Musacchio A, Mol Cell. 2001 Sep;8(3):657-69. PMID:[http:// | + | Structure and regulation of the CDK5-p25(nck5a) complex., Tarricone C, Dhavan R, Peng J, Areces LB, Tsai LH, Musacchio A, Mol Cell. 2001 Sep;8(3):657-69. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/11583627 11583627] |
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Protein complex]] | [[Category: Protein complex]] | ||
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[[Category: cell cycle]] | [[Category: cell cycle]] | ||
[[Category: cell division]] | [[Category: cell division]] | ||
| - | [[Category: cyclin-dependent | + | [[Category: cyclin-dependent kinase]] |
| - | [[Category: | + | [[Category: cyclin]] |
[[Category: p25]] | [[Category: p25]] | ||
[[Category: p35]] | [[Category: p35]] | ||
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[[Category: transferase]] | [[Category: transferase]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 11:32:05 2008'' |
Revision as of 09:32, 20 March 2008
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| , resolution 2.65Å | |||||||
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| Coordinates: | save as pdb, mmCIF, xml | ||||||
STRUCTURE AND REGULATION OF THE CDK5-P25(NCK5A) COMPLEX
Contents |
Overview
CDK5 plays an indispensable role in the central nervous system, and its deregulation is involved in neurodegeneration. We report the crystal structure of a complex between CDK5 and p25, a fragment of the p35 activator. Despite its partial structural similarity with the cyclins, p25 displays an unprecedented mechanism for the regulation of a cyclin-dependent kinase. p25 tethers the unphosphorylated T loop of CDK5 in the active conformation. Residue Ser159, equivalent to Thr160 on CDK2, contributes to the specificity of the CDK5-p35 interaction. Its substitution with threonine prevents p35 binding, while the presence of alanine affects neither binding nor kinase activity. Finally, we provide evidence that the CDK5-p25 complex employs a distinct mechanism from the phospho-CDK2-cyclin A complex to establish substrate specificity.
Disease
Known diseases associated with this structure: Microcephaly, primary autosomal recessive, 3 OMIM:[608201]
About this Structure
1H4L is a Protein complex structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.
Reference
Structure and regulation of the CDK5-p25(nck5a) complex., Tarricone C, Dhavan R, Peng J, Areces LB, Tsai LH, Musacchio A, Mol Cell. 2001 Sep;8(3):657-69. PMID:11583627
Page seeded by OCA on Thu Mar 20 11:32:05 2008
Categories: Homo sapiens | Protein complex | Areces, L. | Dhavan, R. | Musacchio, A. | Peng, J. | Tarricone, C. | Tsai, L H. | Atp-binding | Cdk5 | Cell cycle | Cell division | Cyclin-dependent kinase | Cyclin | P25 | P35 | Phosphorylation | Transferase
