1wce

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[[Image:1wce.png|left|200px]]
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==Crystal structure of the T13 IBDV viral particle reveals a missing link in icosahedral viruses evolution==
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<StructureSection load='1wce' size='340' side='right' caption='[[1wce]], [[Resolution|resolution]] 7.00&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1wce]] is a 13 chain structure with sequence from [http://en.wikipedia.org/wiki/Infectious_bursal_disease_virus Infectious bursal disease virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WCE OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1WCE FirstGlance]. <br>
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</td></tr><tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1wcd|1wcd]]</td></tr>
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<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1wce FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1wce OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1wce RCSB], [http://www.ebi.ac.uk/pdbsum/1wce PDBsum]</span></td></tr>
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<table>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/wc/1wce_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Double-stranded RNA virions are transcriptionally competent icosahedral particles that must translocate across a lipid bilayer to function within the cytoplasm of the target cell. Birnaviruses are unique among dsRNA viruses as they have a single T = 13 icosahedral shell, lacking the characteristic inner capsid observed in the others. We determined the crystal structures of the T = 1 subviral particle (260 angstroms in diameter) and of the T = 13 intact virus particle (700 angstroms in diameter) of an avian birnavirus to 3 angstroms and 7 angstroms resolution, respectively. Our results show that VP2, the only component of the virus icosahedral capsid, is homologous both to the capsid protein of positive-strand RNA viruses, like the T = 3 nodaviruses, and to the T = 13 capsid protein of members of the Reoviridae family of dsRNA viruses. Together, these results provide important insights into the multiple functions of the birnavirus capsid and reveal unexpected structural relationships among icosahedral viruses.
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{{STRUCTURE_1wce| PDB=1wce | SCENE= }}
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The birnavirus crystal structure reveals structural relationships among icosahedral viruses.,Coulibaly F, Chevalier C, Gutsche I, Pous J, Navaza J, Bressanelli S, Delmas B, Rey FA Cell. 2005 Mar 25;120(6):761-72. PMID:15797378<ref>PMID:15797378</ref>
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===CRYSTAL STRUCTURE OF THE T13 IBDV VIRAL PARTICLE REVEALS A MISSING LINK IN ICOSAHEDRAL VIRUSES EVOLUTION===
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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{{ABSTRACT_PUBMED_15797378}}
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== References ==
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<references/>
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==About this Structure==
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__TOC__
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[[1wce]] is a 13 chain structure with sequence from [http://en.wikipedia.org/wiki/Infectious_bursal_disease_virus Infectious bursal disease virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WCE OCA].
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</StructureSection>
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==Reference==
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<ref group="xtra">PMID:015797378</ref><references group="xtra"/>
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[[Category: Infectious bursal disease virus]]
[[Category: Infectious bursal disease virus]]
[[Category: Bressanelli, S.]]
[[Category: Bressanelli, S.]]

Revision as of 20:09, 29 September 2014

Crystal structure of the T13 IBDV viral particle reveals a missing link in icosahedral viruses evolution

1wce, resolution 7.00Å

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