1hjo

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[[Image:1hjo.gif|left|200px]]<br /><applet load="1hjo" size="350" color="white" frame="true" align="right" spinBox="true"
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[[Image:1hjo.gif|left|200px]]
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caption="1hjo, resolution 2.30&Aring;" />
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'''HEAT-SHOCK 70KD PROTEIN 42KD ATPASE N-TERMINAL DOMAIN'''<br />
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{{Structure
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|PDB= 1hjo |SIZE=350|CAPTION= <scene name='initialview01'>1hjo</scene>, resolution 2.30&Aring;
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|SITE=
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|LIGAND= <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene> and <scene name='pdbligand=ADP:ADENOSINE-5'-DIPHOSPHATE'>ADP</scene>
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|ACTIVITY= [http://en.wikipedia.org/wiki/Adenosinetriphosphatase Adenosinetriphosphatase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.6.1.3 3.6.1.3]
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|GENE=
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}}
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'''HEAT-SHOCK 70KD PROTEIN 42KD ATPASE N-TERMINAL DOMAIN'''
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==Overview==
==Overview==
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==About this Structure==
==About this Structure==
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1HJO is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with <scene name='pdbligand=CA:'>CA</scene>, <scene name='pdbligand=CL:'>CL</scene> and <scene name='pdbligand=ADP:'>ADP</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/Adenosinetriphosphatase Adenosinetriphosphatase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.6.1.3 3.6.1.3] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1HJO OCA].
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1HJO is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1HJO OCA].
==Reference==
==Reference==
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Structure of a new crystal form of human Hsp70 ATPase domain., Osipiuk J, Walsh MA, Freeman BC, Morimoto RI, Joachimiak A, Acta Crystallogr D Biol Crystallogr. 1999 May;55(Pt 5):1105-7. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=10216320 10216320]
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Structure of a new crystal form of human Hsp70 ATPase domain., Osipiuk J, Walsh MA, Freeman BC, Morimoto RI, Joachimiak A, Acta Crystallogr D Biol Crystallogr. 1999 May;55(Pt 5):1105-7. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/10216320 10216320]
[[Category: Adenosinetriphosphatase]]
[[Category: Adenosinetriphosphatase]]
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: heat shock]]
[[Category: heat shock]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 13:02:01 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 11:37:54 2008''

Revision as of 09:37, 20 March 2008

Image:1hjo.gif


PDB ID 1hjo

Drag the structure with the mouse to rotate
, resolution 2.30Å
Ligands: , and
Activity: Adenosinetriphosphatase, with EC number 3.6.1.3
Coordinates: save as pdb, mmCIF, xml



HEAT-SHOCK 70KD PROTEIN 42KD ATPASE N-TERMINAL DOMAIN


Overview

Hsp70 proteins are highly conserved proteins induced by heat shock and other stress conditions. An ATP-binding domain of human Hsp70 protein has been crystallized in two major morphological forms at pH 7.0 in the presence of PEG 8000 and CaCl2. Both crystal forms belong to the orthorhombic space group P212121, but show no resemblance in unit-cell parameters. Analysis of the crystal structures for both forms shows a 1-2 A shift of one of the subdomains of the protein. This conformational change could reflect a 'natural' flexibility of the protein which might be relevant to ATP binding and may facilitate the interaction of other proteins with Hsp70 protein.

About this Structure

1HJO is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Structure of a new crystal form of human Hsp70 ATPase domain., Osipiuk J, Walsh MA, Freeman BC, Morimoto RI, Joachimiak A, Acta Crystallogr D Biol Crystallogr. 1999 May;55(Pt 5):1105-7. PMID:10216320

Page seeded by OCA on Thu Mar 20 11:37:54 2008

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