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1hu3
From Proteopedia
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| - | [[Image:1hu3.gif|left|200px]] | + | [[Image:1hu3.gif|left|200px]] |
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| - | '''MIDDLE DOMAIN OF HUMAN EIF4GII''' | + | {{Structure |
| + | |PDB= 1hu3 |SIZE=350|CAPTION= <scene name='initialview01'>1hu3</scene>, resolution 2.37Å | ||
| + | |SITE= | ||
| + | |LIGAND= | ||
| + | |ACTIVITY= | ||
| + | |GENE= | ||
| + | }} | ||
| + | |||
| + | '''MIDDLE DOMAIN OF HUMAN EIF4GII''' | ||
| + | |||
==Overview== | ==Overview== | ||
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==About this Structure== | ==About this Structure== | ||
| - | 1HU3 is a [ | + | 1HU3 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1HU3 OCA]. |
==Reference== | ==Reference== | ||
| - | A conserved HEAT domain within eIF4G directs assembly of the translation initiation machinery., Marcotrigiano J, Lomakin IB, Sonenberg N, Pestova TV, Hellen CU, Burley SK, Mol Cell. 2001 Jan;7(1):193-203. PMID:[http:// | + | A conserved HEAT domain within eIF4G directs assembly of the translation initiation machinery., Marcotrigiano J, Lomakin IB, Sonenberg N, Pestova TV, Hellen CU, Burley SK, Mol Cell. 2001 Jan;7(1):193-203. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/11172724 11172724] |
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
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[[Category: heat repeat]] | [[Category: heat repeat]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 11:41:34 2008'' |
Revision as of 09:41, 20 March 2008
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| Coordinates: | save as pdb, mmCIF, xml | ||||||
MIDDLE DOMAIN OF HUMAN EIF4GII
Overview
The X-ray structure of the phylogenetically conserved middle portion of human eukaryotic initiation factor (eIF) 4GII has been determined at 2.4 A resolution, revealing a crescent-shaped domain consisting of ten alpha helices arranged as five HEAT repeats. Together with the ATP-dependent RNA helicase eIF4A, this HEAT domain suffices for 48S ribosomal complex formation with a picornaviral RNA internal ribosome entry site (IRES). Structure-based site-directed mutagenesis was used to identify two adjacent features on the surface of this essential component of the translation initiation machinery that, respectively, bind eIF4A and a picornaviral IRES. The structural and biochemical results provide mechanistic insights into both cap-dependent and cap-independent translation initiation.
About this Structure
1HU3 is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
A conserved HEAT domain within eIF4G directs assembly of the translation initiation machinery., Marcotrigiano J, Lomakin IB, Sonenberg N, Pestova TV, Hellen CU, Burley SK, Mol Cell. 2001 Jan;7(1):193-203. PMID:11172724
Page seeded by OCA on Thu Mar 20 11:41:34 2008
