2err

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[[Image:2err.png|left|200px]]
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==NMR Structure of the RNA Binding Domain of Human Fox-1 in Complex with UGCAUGU==
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<StructureSection load='2err' size='340' side='right' caption='[[2err]], [[NMR_Ensembles_of_Models | 30 NMR models]]' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[2err]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ERR OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ERR FirstGlance]. <br>
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</td></tr><tr><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">A2BP1, A2BP ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
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<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2err FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2err OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2err RCSB], [http://www.ebi.ac.uk/pdbsum/2err PDBsum]</span></td></tr>
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<table>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/er/2err_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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The Fox-1 protein regulates alternative splicing of tissue-specific exons by binding to GCAUG elements. Here, we report the solution structure of the Fox-1 RNA binding domain (RBD) in complex with UGCAUGU. The last three nucleotides, UGU, are recognized in a canonical way by the four-stranded beta-sheet of the RBD. In contrast, the first four nucleotides, UGCA, are bound by two loops of the protein in an unprecedented manner. Nucleotides U1, G2, and C3 are wrapped around a single phenylalanine, while G2 and A4 form a base-pair. This novel RNA binding site is independent from the beta-sheet binding interface. Surface plasmon resonance analyses were used to quantify the energetic contributions of electrostatic and hydrogen bond interactions to complex formation and support our structural findings. These results demonstrate the unusual molecular mechanism of sequence-specific RNA recognition by Fox-1, which is exceptional in its high affinity for a defined but short sequence element.
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{{STRUCTURE_2err| PDB=2err | SCENE= }}
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Molecular basis of RNA recognition by the human alternative splicing factor Fox-1.,Auweter SD, Fasan R, Reymond L, Underwood JG, Black DL, Pitsch S, Allain FH EMBO J. 2006 Jan 11;25(1):163-73. Epub 2005 Dec 15. PMID:16362037<ref>PMID:16362037</ref>
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===NMR Structure of the RNA Binding Domain of Human Fox-1 in Complex with UGCAUGU===
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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{{ABSTRACT_PUBMED_16362037}}
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== References ==
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<references/>
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==About this Structure==
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__TOC__
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[[2err]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ERR OCA].
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</StructureSection>
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==Reference==
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<ref group="xtra">PMID:016362037</ref><references group="xtra"/>
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Allain, F H.]]
[[Category: Allain, F H.]]

Revision as of 02:28, 30 September 2014

NMR Structure of the RNA Binding Domain of Human Fox-1 in Complex with UGCAUGU

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