This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


1i9k

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
-
[[Image:1i9k.gif|left|200px]]<br /><applet load="1i9k" size="350" color="white" frame="true" align="right" spinBox="true"
+
[[Image:1i9k.gif|left|200px]]
-
caption="1i9k" />
+
 
-
'''THE RNA I-MOTIF'''<br />
+
{{Structure
 +
|PDB= 1i9k |SIZE=350|CAPTION= <scene name='initialview01'>1i9k</scene>
 +
|SITE=
 +
|LIGAND=
 +
|ACTIVITY=
 +
|GENE=
 +
}}
 +
 
 +
'''THE RNA I-MOTIF'''
 +
 
==Overview==
==Overview==
Line 7: Line 16:
==About this Structure==
==About this Structure==
-
1I9K is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/ ]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1I9K OCA].
+
1I9K is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/ ]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1I9K OCA].
==Reference==
==Reference==
-
The RNA i-motif., Snoussi K, Nonin-Lecomte S, Leroy JL, J Mol Biol. 2001 May 25;309(1):139-53. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=11491284 11491284]
+
The RNA i-motif., Snoussi K, Nonin-Lecomte S, Leroy JL, J Mol Biol. 2001 May 25;309(1):139-53. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/11491284 11491284]
[[Category: Protein complex]]
[[Category: Protein complex]]
[[Category: Lerou, J L.]]
[[Category: Lerou, J L.]]
Line 19: Line 28:
[[Category: rna]]
[[Category: rna]]
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 13:09:26 2008''
+
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 11:47:20 2008''

Revision as of 09:47, 20 March 2008

Image:1i9k.gif


PDB ID 1i9k

Drag the structure with the mouse to rotate
Coordinates: save as pdb, mmCIF, xml



THE RNA I-MOTIF


Overview

Oligodeoxynucleotides with stretches of cytidine residues associate into a four-stranded structure, the i-motif, in which two head-to-tail, intercalated, parallel-stranded duplexes are held together by hemiprotonated C.C+ pairs. We have investigated the possibility of forming an i-motif structure with C-rich ribonucleic acids. The four C-rich RNAs studied, r(UC5), r(C5), r(C5U) and r(UC3), associate into multiple intercalated structures at acidic pH. r(UC5) forms two i-motif structures that differ by their intercalation topologies. We report on a structural study of the main form and we analyze the small conformational differences found by comparison with the DNA i-motif. The stacking topology of the main structure avoids one of the six 2'-OH/2'-OH repulsive contacts expected in a fully intercalated structure. The C3'-endo pucker of the RNA sugars and the orientation of the intercalated C.C+ pairs result in a modest widening of the narrow grooves at the steps where the hydroxyl groups are in close contact. The free energy of the RNA i-motif, on average -4 kJ mol(-1) per C.C+ pair, is half of the value found in DNA i-motif structures.

About this Structure

1I9K is a Protein complex structure of sequences from [1]. Full crystallographic information is available from OCA.

Reference

The RNA i-motif., Snoussi K, Nonin-Lecomte S, Leroy JL, J Mol Biol. 2001 May 25;309(1):139-53. PMID:11491284

Page seeded by OCA on Thu Mar 20 11:47:20 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1i9k"
Personal tools