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1ico
From Proteopedia
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| - | [[Image:1ico.jpg|left|200px]] | + | [[Image:1ico.jpg|left|200px]] |
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| - | '''SOLUTION STRUCTURE OF DESIGNED BETA-SHEET MINI-PROTEIN TH10BOX''' | + | {{Structure |
| + | |PDB= 1ico |SIZE=350|CAPTION= <scene name='initialview01'>1ico</scene> | ||
| + | |SITE= | ||
| + | |LIGAND= | ||
| + | |ACTIVITY= | ||
| + | |GENE= | ||
| + | }} | ||
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| + | '''SOLUTION STRUCTURE OF DESIGNED BETA-SHEET MINI-PROTEIN TH10BOX''' | ||
| + | |||
==Overview== | ==Overview== | ||
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==About this Structure== | ==About this Structure== | ||
| - | 1ICO is a [ | + | 1ICO is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/ ]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ICO OCA]. |
==Reference== | ==Reference== | ||
| - | Design of a discretely folded mini-protein motif with predominantly beta-structure., Ottesen JJ, Imperiali B, Nat Struct Biol. 2001 Jun;8(6):535-9. PMID:[http:// | + | Design of a discretely folded mini-protein motif with predominantly beta-structure., Ottesen JJ, Imperiali B, Nat Struct Biol. 2001 Jun;8(6):535-9. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/11373623 11373623] |
[[Category: Protein complex]] | [[Category: Protein complex]] | ||
[[Category: Imperiali, B.]] | [[Category: Imperiali, B.]] | ||
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[[Category: de novo protein design three-stranded beta-sheet mini-protein motif th motif]] | [[Category: de novo protein design three-stranded beta-sheet mini-protein motif th motif]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 11:48:37 2008'' |
Revision as of 09:48, 20 March 2008
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| Coordinates: | save as pdb, mmCIF, xml | ||||||
SOLUTION STRUCTURE OF DESIGNED BETA-SHEET MINI-PROTEIN TH10BOX
Overview
Here we report the creation of a predominantly beta-structured mini-protein motif. The design target is based on the naturally occurring toxin hand (TH) motifs that are composed of four disulfide bonds and three loops that form a 'hand'. Analysis and subsequent modification of several generations of mini-proteins produced the final 29-residue mini-protein. The structured motif of this new mini-protein provides insight into the compensatory changes that result in the formation of a tightly packed hydrophobic core in a small, globular beta-structure motif. Additionally, this mini-motif represents a new, distinct surface topology for protein design and a valuable, yet compact, model system for the study of beta-sheet structure in water.
About this Structure
1ICO is a Protein complex structure of sequences from [1]. Full crystallographic information is available from OCA.
Reference
Design of a discretely folded mini-protein motif with predominantly beta-structure., Ottesen JJ, Imperiali B, Nat Struct Biol. 2001 Jun;8(6):535-9. PMID:11373623
Page seeded by OCA on Thu Mar 20 11:48:37 2008
