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2wng

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[[Image:2wng.png|left|200px]]
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==COMPLETE EXTRACELLULAR STRUCTURE OF HUMAN SIGNAL REGULATORY PROTEIN (SIRP) ALPHA==
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<StructureSection load='2wng' size='340' side='right' caption='[[2wng]], [[Resolution|resolution]] 2.49&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[2wng]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WNG OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2WNG FirstGlance]. <br>
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</td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene><br>
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<tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2jjt|2jjt]], [[2uv3|2uv3]], [[2jjs|2jjs]]</td></tr>
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<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2wng FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wng OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2wng RCSB], [http://www.ebi.ac.uk/pdbsum/2wng PDBsum]</span></td></tr>
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<table>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/wn/2wng_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Signal-regulatory protein alpha (SIRPalpha) is a myeloid membrane receptor that interacts with the membrane protein CD47, a marker of self. We have solved the structure of the complete extracellular portion of SIRPalpha, comprising three immunoglobulin superfamily domains, by x-ray crystallography to 2.5 A resolution. These data, together with previous data on the N-terminal domain and its ligand CD47 (possessing a single immunoglobulin superfamily domain), show that the CD47-SIRPalpha interaction will span a distance of around 14 nm between interacting cells, comparable with that of an immunological synapse. The N-terminal (V-set) domain mediates binding to CD47, and the two others are found to be constant (C1-set) domains. C1-set domains are restricted to proteins involved in vertebrate antigen recognition: T cell antigen receptors, immunoglobulins, major histocompatibility complex antigens, tapasin, and beta2-microglobulin. The domains of SIRPalpha (domains 2 and 3) are structurally more similar to C1-set domains than any cell surface protein not involved in antigen recognition. This strengthens the suggestion from sequence analysis that SIRP is evolutionarily closely related to antigen recognition proteins.
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{{STRUCTURE_2wng| PDB=2wng | SCENE= }}
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Structure of signal-regulatory protein alpha: a link to antigen receptor evolution.,Hatherley D, Graham SC, Harlos K, Stuart DI, Barclay AN J Biol Chem. 2009 Sep 25;284(39):26613-9. Epub 2009 Jul 23. PMID:19628875<ref>PMID:19628875</ref>
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===COMPLETE EXTRACELLULAR STRUCTURE OF HUMAN SIGNAL REGULATORY PROTEIN (SIRP) ALPHA===
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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{{ABSTRACT_PUBMED_19628875}}
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== References ==
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<references/>
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==About this Structure==
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__TOC__
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[[2wng]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WNG OCA].
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</StructureSection>
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==Reference==
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<ref group="xtra">PMID:019628875</ref><references group="xtra"/>
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Barclay, A N.]]
[[Category: Barclay, A N.]]

Revision as of 01:13, 1 October 2014

COMPLETE EXTRACELLULAR STRUCTURE OF HUMAN SIGNAL REGULATORY PROTEIN (SIRP) ALPHA

2wng, resolution 2.49Å

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