This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


2vuc

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
-
[[Image:2vuc.png|left|200px]]
+
==PA-IIL LECTIN FROM PSEUDOMONAS AERUGINOSA COMPLEXED WITH FUCOSE-DERIVED GLYCOMIMETICS==
 +
<StructureSection load='2vuc' size='340' side='right' caption='[[2vuc]], [[Resolution|resolution]] 1.30&Aring;' scene=''>
 +
== Structural highlights ==
 +
<table><tr><td colspan='2'>[[2vuc]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Pseudomonas_aeruginosa Pseudomonas aeruginosa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VUC OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2VUC FirstGlance]. <br>
 +
</td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=FUC:ALPHA-L-FUCOSE'>FUC</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=YX0:[(3E)-3-(1-HYDROXYETHYLIDENE)-2,3-DIHYDROISOXAZOL-5-YL]METHYL+6-DEOXY-ALPHA-L-GALACTOPYRANOSIDE'>YX0</scene><br>
 +
<tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1ovs|1ovs]], [[1oxc|1oxc]], [[1w8f|1w8f]], [[2jdk|2jdk]], [[1oux|1oux]], [[1gzt|1gzt]], [[2jdh|2jdh]], [[2jdy|2jdy]], [[1ous|1ous]], [[2jdu|2jdu]], [[1ovp|1ovp]], [[2jdp|2jdp]], [[1our|1our]], [[1uzv|1uzv]], [[2boj|2boj]], [[2bp6|2bp6]], [[2jdm|2jdm]], [[2jdn|2jdn]], [[1w43|1w43]], [[1w8h|1w8h]], [[2vud|2vud]]</td></tr>
 +
<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2vuc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vuc OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2vuc RCSB], [http://www.ebi.ac.uk/pdbsum/2vuc PDBsum]</span></td></tr>
 +
<table>
 +
== Evolutionary Conservation ==
 +
[[Image:Consurf_key_small.gif|200px|right]]
 +
Check<jmol>
 +
<jmolCheckbox>
 +
<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/vu/2vuc_consurf.spt"</scriptWhenChecked>
 +
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
 +
<text>to colour the structure by Evolutionary Conservation</text>
 +
</jmolCheckbox>
 +
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
 +
<div style="clear:both"></div>
 +
<div style="background-color:#fffaf0;">
 +
== Publication Abstract from PubMed ==
 +
Pseudomonas aeruginosa galactose- and fucose-binding lectins (PA-IL and PA-IIL) contribute to the virulence of this pathogenic bacterium, which is a major cause of morbidity and mortality in cystic fibrosis patients. The crystal structure of PA-IIL in complex with fucose reveals a tetrameric structure. Each monomer displays a nine-stranded, antiparallel b-sandwich arrangement and contains two close calcium cations that mediate the binding of fucose in a recognition mode unique among carbohydrate-protein interactions. Experimental binding studies, together with theoretical docking of fucose-containing oligosaccharides, are consistent with the assumption that antigens of the Lewis a (Le(a)) series may be the preferred ligands of this lectin. Precise knowledge of the lectin-binding site should allow a better design of new antibacterial-adhesion prophylactics.
-
{{STRUCTURE_2vuc| PDB=2vuc | SCENE= }}
+
Structural basis for oligosaccharide-mediated adhesion of Pseudomonas aeruginosa in the lungs of cystic fibrosis patients.,Mitchell E, Houles C, Sudakevitz D, Wimmerova M, Gautier C, Perez S, Wu AM, Gilboa-Garber N, Imberty A Nat Struct Biol. 2002 Dec;9(12):918-21. PMID:12415289<ref>PMID:12415289</ref>
-
===PA-IIL LECTIN FROM PSEUDOMONAS AERUGINOSA COMPLEXED WITH FUCOSE-DERIVED GLYCOMIMETICS===
+
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
-
 
+
</div>
-
{{ABSTRACT_PUBMED_12415289}}
+
== References ==
-
 
+
<references/>
-
==About this Structure==
+
__TOC__
-
[[2vuc]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Pseudomonas_aeruginosa Pseudomonas aeruginosa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VUC OCA].
+
</StructureSection>
-
 
+
-
==Reference==
+
-
<ref group="xtra">PMID:012415289</ref><ref group="xtra">PMID:015790314</ref><ref group="xtra">PMID:017623286</ref><references group="xtra"/>
+
[[Category: Pseudomonas aeruginosa]]
[[Category: Pseudomonas aeruginosa]]
[[Category: Beha, S.]]
[[Category: Beha, S.]]

Revision as of 01:36, 1 October 2014

PA-IIL LECTIN FROM PSEUDOMONAS AERUGINOSA COMPLEXED WITH FUCOSE-DERIVED GLYCOMIMETICS

2vuc, resolution 1.30Å

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/2vuc"
Views
Personal tools
Navigation
Toolbox