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2zrr

From Proteopedia

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[[Image:2zrr.png|left|200px]]
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==Crystal structure of an immunity protein that contributes to the self-protection of bacteriocin-producing Enterococcus mundtii 15-1A==
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<StructureSection load='2zrr' size='340' side='right' caption='[[2zrr]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[2zrr]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Enterococcus_mundtii Enterococcus mundtii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ZRR OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ZRR FirstGlance]. <br>
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</td></tr><tr><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">orf8 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=53346 Enterococcus mundtii])</td></tr>
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<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2zrr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2zrr OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2zrr RCSB], [http://www.ebi.ac.uk/pdbsum/2zrr PDBsum]</span></td></tr>
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<table>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/zr/2zrr_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Bacteriocin-producing lactic acid bacteria (LAB) possess a self-protection factor, which is generally called an immunity protein. In this study, we determine the crystal structure of an immunity protein, designated Mun-im, which was classified into subgroup B immunity proteins for class IIa bacteriocins. The Mun-im protein takes a left-turning antiparallel four-helix bundle structure with the flexible N- and C-terminal parts. Although the amino acid sequences of the subgroup B immunity proteins are distinguished from those of the subgroup A, the core structure of Mun-im is well-superimposed with that of the subgroup A immunity protein, EntA-im, and the C-terminus of both proteins is flexible. However, the C-terminus of Mun-im is obviously shorter than that of the subgroup A. We found through mutagenic study of Mun-im that the C-terminus and the K86 residue on the helix 4 in the immunity protein molecule are important for expression of the immunity activity on the subgroup B immunity proteins.
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{{STRUCTURE_2zrr| PDB=2zrr | SCENE= }}
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Crystal structure and mutagenic analysis of a bacteriocin immunity protein, Mun-im.,Jeon HJ, Noda M, Matoba Y, Kumagai T, Sugiyama M Biochem Biophys Res Commun. 2009 Jan 16;378(3):574-8. Epub 2008 Dec 4. PMID:19061861<ref>PMID:19061861</ref>
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===Crystal structure of an immunity protein that contributes to the self-protection of bacteriocin-producing Enterococcus mundtii 15-1A===
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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{{ABSTRACT_PUBMED_19061861}}
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== References ==
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<references/>
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==About this Structure==
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__TOC__
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[[2zrr]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Enterococcus_mundtii Enterococcus mundtii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ZRR OCA].
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</StructureSection>
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==Reference==
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<ref group="xtra">PMID:019061861</ref><references group="xtra"/>
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[[Category: Enterococcus mundtii]]
[[Category: Enterococcus mundtii]]
[[Category: Jeon, H J.]]
[[Category: Jeon, H J.]]

Revision as of 05:28, 2 October 2014

Crystal structure of an immunity protein that contributes to the self-protection of bacteriocin-producing Enterococcus mundtii 15-1A

2zrr, resolution 1.80Å

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