1j4j
From Proteopedia
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| - | [[Image:1j4j.jpg|left|200px]] | + | [[Image:1j4j.jpg|left|200px]] |
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| - | '''Crystal Structure of Tabtoxin Resistance Protein (form II) complexed with an Acyl Coenzyme A''' | + | {{Structure |
| + | |PDB= 1j4j |SIZE=350|CAPTION= <scene name='initialview01'>1j4j</scene>, resolution 2.55Å | ||
| + | |SITE= | ||
| + | |LIGAND= <scene name='pdbligand=ACO:ACETYL COENZYME *A'>ACO</scene> | ||
| + | |ACTIVITY= | ||
| + | |GENE= | ||
| + | }} | ||
| + | |||
| + | '''Crystal Structure of Tabtoxin Resistance Protein (form II) complexed with an Acyl Coenzyme A''' | ||
| + | |||
==Overview== | ==Overview== | ||
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==About this Structure== | ==About this Structure== | ||
| - | 1J4J is a [ | + | 1J4J is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Pseudomonas_syringae_pv._tabaci Pseudomonas syringae pv. tabaci]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1J4J OCA]. |
==Reference== | ==Reference== | ||
| - | Crystal structure of tabtoxin resistance protein complexed with acetyl coenzyme A reveals the mechanism for beta-lactam acetylation., He H, Ding Y, Bartlam M, Sun F, Le Y, Qin X, Tang H, Zhang R, Joachimiak A, Liu J, Zhao N, Rao Z, J Mol Biol. 2003 Jan 31;325(5):1019-30. PMID:[http:// | + | Crystal structure of tabtoxin resistance protein complexed with acetyl coenzyme A reveals the mechanism for beta-lactam acetylation., He H, Ding Y, Bartlam M, Sun F, Le Y, Qin X, Tang H, Zhang R, Joachimiak A, Liu J, Zhao N, Rao Z, J Mol Biol. 2003 Jan 31;325(5):1019-30. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/12527305 12527305] |
[[Category: Pseudomonas syringae pv. tabaci]] | [[Category: Pseudomonas syringae pv. tabaci]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
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[[Category: transferase]] | [[Category: transferase]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 11:58:52 2008'' |
Revision as of 09:58, 20 March 2008
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| , resolution 2.55Å | |||||||
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| Coordinates: | save as pdb, mmCIF, xml | ||||||
Crystal Structure of Tabtoxin Resistance Protein (form II) complexed with an Acyl Coenzyme A
Overview
Tabtoxin resistance protein (TTR) is an enzyme that renders tabtoxin-producing pathogens, such as Pseudomonas syringae, tolerant to their own phytotoxins. Here, we report the crystal structure of TTR complexed with its natural cofactor, acetyl coenzyme A (AcCoA), to 1.55A resolution. The binary complex forms a characteristic "V" shape for substrate binding and contains the four motifs conserved in the GCN5-related N-acetyltransferase (GNAT) superfamily, which also includes the histone acetyltransferases (HATs). A single-step mechanism is proposed to explain the function of three conserved residues, Glu92, Asp130 and Tyr141, in catalyzing the acetyl group transfer to its substrate. We also report that TTR possesses HAT activity and suggest an evolutionary relationship between TTR and other GNAT members.
About this Structure
1J4J is a Single protein structure of sequence from Pseudomonas syringae pv. tabaci. Full crystallographic information is available from OCA.
Reference
Crystal structure of tabtoxin resistance protein complexed with acetyl coenzyme A reveals the mechanism for beta-lactam acetylation., He H, Ding Y, Bartlam M, Sun F, Le Y, Qin X, Tang H, Zhang R, Joachimiak A, Liu J, Zhao N, Rao Z, J Mol Biol. 2003 Jan 31;325(5):1019-30. PMID:12527305
Page seeded by OCA on Thu Mar 20 11:58:52 2008
Categories: Pseudomonas syringae pv. tabaci | Single protein | Bartlam, M. | Cao, Z. | Ding, Y. | Duke, N. | He, H. | Jiang, F. | Joachimiak, A. | Liu, J. | Liu, Y. | Rao, Z. | Shao, Y. | Tang, H. | Zhang, R. | Zhao, N. | ACO | Transferase
