This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


2atb

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
m (Protected "2atb" [edit=sysop:move=sysop])
Line 1: Line 1:
-
{{STRUCTURE_2atb| PDB=2atb | SCENE= }}
+
==Triple mutant 8D9D10V of scorpion toxin LQH-alpha-IT==
-
===Triple mutant 8D9D10V of scorpion toxin LQH-alpha-IT===
+
<StructureSection load='2atb' size='340' side='right' caption='[[2atb]], [[Resolution|resolution]] 1.60&Aring;' scene=''>
-
 
+
== Structural highlights ==
-
==Function==
+
<table><tr><td colspan='2'>[[2atb]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Leiurus_quinquestriatus Leiurus quinquestriatus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ATB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ATB FirstGlance]. <br>
-
[[http://www.uniprot.org/uniprot/SCXA_LEIQH SCXA_LEIQH]] Alpha toxins bind voltage-independently at site-3 of sodium channels (Nav) and inhibit the inactivation of the activated channels, thereby blocking neuronal transmission. The dissociation is voltage-dependent. This toxin is active on insects. It is also highly toxic to crustaceans and has a measurable but low toxicity to mice.
+
</td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=NO3:NITRATE+ION'>NO3</scene><br>
-
 
+
<tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2asc|2asc]], [[1lqh|1lqh]]</td></tr>
-
==About this Structure==
+
<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2atb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2atb OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2atb RCSB], [http://www.ebi.ac.uk/pdbsum/2atb PDBsum]</span></td></tr>
-
[[2atb]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Leiurus_quinquestriatus Leiurus quinquestriatus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ATB OCA].
+
<table>
 +
== Evolutionary Conservation ==
 +
[[Image:Consurf_key_small.gif|200px|right]]
 +
Check<jmol>
 +
<jmolCheckbox>
 +
<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/at/2atb_consurf.spt"</scriptWhenChecked>
 +
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
 +
<text>to colour the structure by Evolutionary Conservation</text>
 +
</jmolCheckbox>
 +
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
 +
<div style="clear:both"></div>
 +
__TOC__
 +
</StructureSection>
[[Category: Leiurus quinquestriatus]]
[[Category: Leiurus quinquestriatus]]
[[Category: Frolow, F.]]
[[Category: Frolow, F.]]

Revision as of 11:44, 3 October 2014

Triple mutant 8D9D10V of scorpion toxin LQH-alpha-IT

2atb, resolution 1.60Å

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/2atb"
Views
Personal tools
Navigation
Toolbox