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4ono

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'''Unreleased structure'''
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==CD1c in complex with PM (phosphomycoketide)==
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<StructureSection load='4ono' size='340' side='right' caption='[[4ono]], [[Resolution|resolution]] 2.71&Aring;' scene=''>
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The entry 4ono is ON HOLD until Paper Publication
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== Structural highlights ==
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<table><tr><td colspan='2'>[[4ono]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ONO OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ONO FirstGlance]. <br>
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Authors: Roy, S., Adams, E.J.
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=MLI:MALONATE+ION'>MLI</scene>, <scene name='pdbligand=PMK:(4R,8S,16S,20R)-4,8,12,16,20-PENTAMETHYLHEPTACOSYL+DIHYDROGEN+PHOSPHATE'>PMK</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ono FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ono OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4ono RCSB], [http://www.ebi.ac.uk/pdbsum/4ono PDBsum]</span></td></tr>
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Description:
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</table>
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== Disease ==
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[[http://www.uniprot.org/uniprot/B2MG_HUMAN B2MG_HUMAN]] Defects in B2M are the cause of hypercatabolic hypoproteinemia (HYCATHYP) [MIM:[http://omim.org/entry/241600 241600]]. Affected individuals show marked reduction in serum concentrations of immunoglobulin and albumin, probably due to rapid degradation.<ref>PMID:16549777</ref> Note=Beta-2-microglobulin may adopt the fibrillar configuration of amyloid in certain pathologic states. The capacity to assemble into amyloid fibrils is concentration dependent. Persistently high beta(2)-microglobulin serum levels lead to amyloidosis in patients on long-term hemodialysis.<ref>PMID:3532124</ref> <ref>PMID:1336137</ref> <ref>PMID:7554280</ref> <ref>PMID:4586824</ref> <ref>PMID:8084451</ref> <ref>PMID:12119416</ref> <ref>PMID:12796775</ref> <ref>PMID:16901902</ref> <ref>PMID:16491088</ref> <ref>PMID:17646174</ref> <ref>PMID:18835253</ref> <ref>PMID:18395224</ref> <ref>PMID:19284997</ref>
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== Function ==
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[[http://www.uniprot.org/uniprot/B2MG_HUMAN B2MG_HUMAN]] Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Adams, E J.]]
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[[Category: Roy, S.]]
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[[Category: Antigen presentation]]
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[[Category: Cd1c]]
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[[Category: Ig fold]]
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[[Category: Immune system]]
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[[Category: Tcr]]

Revision as of 07:51, 8 October 2014

CD1c in complex with PM (phosphomycoketide)

4ono, resolution 2.71Å

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