1r3g

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[[Image:1r3g.png|left|200px]]
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==1.16A X-ray structure of the synthetic DNA fragment with the incorporated 2'-O-[(2-Guanidinium)ethyl]-5-methyluridine residues==
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<StructureSection load='1r3g' size='340' side='right' caption='[[1r3g]], [[Resolution|resolution]] 1.16&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1r3g]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1R3G OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1R3G FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
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<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=GMU:2-O-[(2-GUANIDINIUM)ETHYL]-5-METHYLURIDINE+5-MONOPHOSPHATE'>GMU</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1r3g FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1r3g OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1r3g RCSB], [http://www.ebi.ac.uk/pdbsum/1r3g PDBsum]</span></td></tr>
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</table>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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[structure: see text] Oligonucleotides with a novel 2'-O-[2-(guanidinium)ethyl] (2'-O-GE) modification have been synthesized using a novel protecting group strategy for the guanidinium group. This modification enhances the binding affinity of oligonucleotides to RNA as well as duplex DNA (DeltaT(m) 3.2 degrees C per modification). The 2'-O-GE modified oligonucleotides exhibited exceptional resistance to nuclease degradation. The crystal structure of a palindromic duplex formed by a DNA oligonucleotide with a single 2'-O-GE modification was solved at 1.16 A resolution.
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{{STRUCTURE_1r3g| PDB=1r3g | SCENE= }}
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2'-O-[2-(guanidinium)ethyl]-modified oligonucleotides: stabilizing effect on duplex and triplex structures.,Prakash TP, Puschl A, Lesnik E, Mohan V, Tereshko V, Egli M, Manoharan M Org Lett. 2004 Jun 10;6(12):1971-4. PMID:15176796<ref>PMID:15176796</ref>
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===1.16A X-ray structure of the synthetic DNA fragment with the incorporated 2'-O-[(2-Guanidinium)ethyl]-5-methyluridine residues===
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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{{ABSTRACT_PUBMED_15176796}}
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== References ==
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<references/>
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==About this Structure==
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__TOC__
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[[1r3g]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1R3G OCA].
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</StructureSection>
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==Reference==
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<ref group="xtra">PMID:015176796</ref><references group="xtra"/>
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[[Category: Egli, M.]]
[[Category: Egli, M.]]
[[Category: Lesnik, E.]]
[[Category: Lesnik, E.]]

Revision as of 08:17, 8 October 2014

1.16A X-ray structure of the synthetic DNA fragment with the incorporated 2'-O-[(2-Guanidinium)ethyl]-5-methyluridine residues

1r3g, resolution 1.16Å

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