1smz
From Proteopedia
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| - | [[ | + | ==Structure of Transportan in phospholipid bicellar solution== |
| + | <StructureSection load='1smz' size='340' side='right' caption='[[1smz]], [[NMR_Ensembles_of_Models | 25 NMR models]]' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[1smz]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1SMZ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1SMZ FirstGlance]. <br> | ||
| + | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1smz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1smz OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1smz RCSB], [http://www.ebi.ac.uk/pdbsum/1smz PDBsum]</span></td></tr> | ||
| + | </table> | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | Transportan is a chimeric cell-penetrating peptide constructed from the peptides galanin and mastoparan, which has the ability to internalize living cells carrying a hydrophilic load. In this study, we have determined the NMR solution structure and investigated the position of transportan in neutral bicelles. The structure revealed a well-defined alpha-helix in the C-terminal mastoparan part of the peptide and a weaker tendency to form an alpha-helix in the N-terminal domain. The position of the peptide in relation to the membrane, as studied by adding paramagnetic probes, shows that the peptide lies parallel to, and in the head-group region of the membrane surface. This result is supported by amide proton secondary chemical shifts. | ||
| - | + | NMR solution structure and position of transportan in neutral phospholipid bicelles.,Barany-Wallje E, Andersson A, Graslund A, Maler L FEBS Lett. 2004 Jun 4;567(2-3):265-9. PMID:15178334<ref>PMID:15178334</ref> | |
| - | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |
| - | + | </div> | |
| - | + | == References == | |
| - | + | <references/> | |
| - | == | + | __TOC__ |
| - | + | </StructureSection> | |
[[Category: Andersson, A.]] | [[Category: Andersson, A.]] | ||
[[Category: Barany-Wallje, E.]] | [[Category: Barany-Wallje, E.]] | ||
Revision as of 08:34, 8 October 2014
Structure of Transportan in phospholipid bicellar solution
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