1ji7

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[[Image:1ji7.gif|left|200px]]<br /><applet load="1ji7" size="350" color="white" frame="true" align="right" spinBox="true"
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[[Image:1ji7.gif|left|200px]]
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caption="1ji7, resolution 1.45&Aring;" />
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'''Crystal Structure of TEL SAM Polymer'''<br />
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{{Structure
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|PDB= 1ji7 |SIZE=350|CAPTION= <scene name='initialview01'>1ji7</scene>, resolution 1.45&Aring;
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|SITE=
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|LIGAND= <scene name='pdbligand=SO4:SULFATE ION'>SO4</scene>
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|ACTIVITY=
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|GENE= TEL ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
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}}
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'''Crystal Structure of TEL SAM Polymer'''
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==Overview==
==Overview==
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==About this Structure==
==About this Structure==
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1JI7 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with <scene name='pdbligand=SO4:'>SO4</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JI7 OCA].
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1JI7 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JI7 OCA].
==Reference==
==Reference==
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Polymerization of the SAM domain of TEL in leukemogenesis and transcriptional repression., Kim CA, Phillips ML, Kim W, Gingery M, Tran HH, Robinson MA, Faham S, Bowie JU, EMBO J. 2001 Aug 1;20(15):4173-82. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=11483520 11483520]
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Polymerization of the SAM domain of TEL in leukemogenesis and transcriptional repression., Kim CA, Phillips ML, Kim W, Gingery M, Tran HH, Robinson MA, Faham S, Bowie JU, EMBO J. 2001 Aug 1;20(15):4173-82. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/11483520 11483520]
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Single protein]]
[[Category: Single protein]]
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[[Category: helical polymer]]
[[Category: helical polymer]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 13:22:56 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 12:03:45 2008''

Revision as of 10:03, 20 March 2008

Image:1ji7.gif


PDB ID 1ji7

Drag the structure with the mouse to rotate
, resolution 1.45Å
Ligands:
Gene: TEL (Homo sapiens)
Coordinates: save as pdb, mmCIF, xml



Crystal Structure of TEL SAM Polymer


Contents

Overview

TEL is a transcriptional repressor that is a frequent target of chromosomal translocations in a large number of hematalogical malignancies. These rearrangements fuse a potent oligomerization module, the SAM domain of TEL, to a variety of tyrosine kinases or transcriptional regulatory proteins. The self-associating property of TEL-SAM is essential for cell transformation in many, if not all of these diseases. Here we show that the TEL-SAM domain forms a helical, head-to-tail polymeric structure held together by strong intermolecular contacts, providing the first clear demonstration that SAM domains can polymerize. Our results also suggest a mechanism by which SAM domains could mediate the spreading of transcriptional repression complexes along the chromosome.

Disease

Known diseases associated with this structure: Leukemia, acute myeloid, somatic OMIM:[600618]

About this Structure

1JI7 is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Polymerization of the SAM domain of TEL in leukemogenesis and transcriptional repression., Kim CA, Phillips ML, Kim W, Gingery M, Tran HH, Robinson MA, Faham S, Bowie JU, EMBO J. 2001 Aug 1;20(15):4173-82. PMID:11483520

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