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2kw3

From Proteopedia

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[[Image:2kw3.png|left|200px]]
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==Heterotrimeric interaction between RFX5 and RFXAP==
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<StructureSection load='2kw3' size='340' side='right' caption='[[2kw3]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''>
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{{STRUCTURE_2kw3| PDB=2kw3 | SCENE= }}
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== Structural highlights ==
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<table><tr><td colspan='2'>[[2kw3]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KW3 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2KW3 FirstGlance]. <br>
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===Heterotrimeric interaction between RFX5 and RFXAP===
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</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">RFX5 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens]), RFXAP ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2kw3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2kw3 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2kw3 RCSB], [http://www.ebi.ac.uk/pdbsum/2kw3 PDBsum]</span></td></tr>
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{{ABSTRACT_PUBMED_020732328}}
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</table>
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== Disease ==
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==About this Structure==
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[[http://www.uniprot.org/uniprot/RFX5_HUMAN RFX5_HUMAN]] Immunodeficiency by defective expression of HLA class 2. The disease is caused by mutations affecting the gene represented in this entry. [[http://www.uniprot.org/uniprot/RFXAP_HUMAN RFXAP_HUMAN]] Immunodeficiency by defective expression of HLA class 2. The disease is caused by mutations affecting the gene represented in this entry.
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[[2kw3]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KW3 OCA].
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== Function ==
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[[http://www.uniprot.org/uniprot/RFX5_HUMAN RFX5_HUMAN]] Activates transcription from class II MHC promoters. Recognizes X-boxes. Mediates cooperative binding between RFX and NF-Y. RFX binds the X1 box of MHC-II promoters. [[http://www.uniprot.org/uniprot/RFXAP_HUMAN RFXAP_HUMAN]] Part of the RFX complex that binds to the X-box of MHC II promoters.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/kw/2kw3_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
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<div style="clear:both"></div>
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Boss, J M.]]
[[Category: Boss, J M.]]

Revision as of 11:22, 20 October 2014

Heterotrimeric interaction between RFX5 and RFXAP

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