2l8c

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[[Image:2l8c.png|left|200px]]
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==NMR Spectroscopy and Molecular Dynamics Simulation of r(CCGCUGCGG)2 Reveal a Dynamic UU Internal Loop Found in Myotonic Dystrophy Type 1 - UU pair with zero hydrogen bond pairs==
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<StructureSection load='2l8c' size='340' side='right' caption='[[2l8c]], [[NMR_Ensembles_of_Models | 1 NMR models]]' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[2l8c]] is a 2 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2L8C OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2L8C FirstGlance]. <br>
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</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2l8c FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2l8c OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2l8c RCSB], [http://www.ebi.ac.uk/pdbsum/2l8c PDBsum]</span></td></tr>
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</table>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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The NMR structure of an RNA with a copy of the 5'CUG/3'GUC motif found in the triplet repeating disorder myotonic dystrophy type 1 (DM1) is disclosed. The lowest energy conformation of the UU pair is a single-hydrogen bond structure; however, the UU protons undergo exchange indicating structural dynamics. Molecular dynamics simulations show that the single hydrogen bond structure is the most populated one but the UU pair interconverts among zero, one, and two hydrogen bond pairs. These studies have implications for the recognition of the DM1 RNA by small molecules and proteins.
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{{STRUCTURE_2l8c| PDB=2l8c | SCENE= }}
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NMR Spectroscopy and Molecular Dynamics Simulation of r(CCGCUGCGG)(2) Reveal a Dynamic UU Internal Loop Found in Myotonic Dystrophy Type 1.,Parkesh R, Fountain M, Disney MD Biochemistry. 2011 Feb 8;50(5):599-601. Epub 2011 Jan 13. PMID:21204525<ref>PMID:21204525</ref>
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===NMR Spectroscopy and Molecular Dynamics Simulation of r(CCGCUGCGG)2 Reveal a Dynamic UU Internal Loop Found in Myotonic Dystrophy Type 1 - UU pair with zero hydrogen bond pairs===
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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{{ABSTRACT_PUBMED_21204525}}
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== References ==
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<references/>
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==About this Structure==
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__TOC__
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[[2l8c]] is a 2 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2L8C OCA].
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</StructureSection>
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==Reference==
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<ref group="xtra">PMID:021204525</ref><references group="xtra"/>
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[[Category: Disney, M D.]]
[[Category: Disney, M D.]]
[[Category: Fountain, M A.]]
[[Category: Fountain, M A.]]

Revision as of 11:25, 20 October 2014

NMR Spectroscopy and Molecular Dynamics Simulation of r(CCGCUGCGG)2 Reveal a Dynamic UU Internal Loop Found in Myotonic Dystrophy Type 1 - UU pair with zero hydrogen bond pairs

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