1k2d
From Proteopedia
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| - | [[Image:1k2d.jpg|left|200px]] | + | [[Image:1k2d.jpg|left|200px]] |
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| - | '''Crystal structure of the autoimmune MHC class II I-Au complexed with myelin basic protein 1-11 at 2.2A''' | + | {{Structure |
| + | |PDB= 1k2d |SIZE=350|CAPTION= <scene name='initialview01'>1k2d</scene>, resolution 2.2Å | ||
| + | |SITE= | ||
| + | |LIGAND= <scene name='pdbligand=NDG:2-(ACETYLAMINO)-2-DEOXY-A-D-GLUCOPYRANOSE'>NDG</scene> and <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene> | ||
| + | |ACTIVITY= | ||
| + | |GENE= | ||
| + | }} | ||
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| + | '''Crystal structure of the autoimmune MHC class II I-Au complexed with myelin basic protein 1-11 at 2.2A''' | ||
| + | |||
==Overview== | ==Overview== | ||
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==About this Structure== | ==About this Structure== | ||
| - | 1K2D is a [ | + | 1K2D is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1K2D OCA]. |
==Reference== | ==Reference== | ||
| - | Structural snapshot of aberrant antigen presentation linked to autoimmunity: the immunodominant epitope of MBP complexed with I-Au., He XL, Radu C, Sidney J, Sette A, Ward ES, Garcia KC, Immunity. 2002 Jul;17(1):83-94. PMID:[http:// | + | Structural snapshot of aberrant antigen presentation linked to autoimmunity: the immunodominant epitope of MBP complexed with I-Au., He XL, Radu C, Sidney J, Sette A, Ward ES, Garcia KC, Immunity. 2002 Jul;17(1):83-94. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/12150894 12150894] |
[[Category: Mus musculus]] | [[Category: Mus musculus]] | ||
[[Category: Protein complex]] | [[Category: Protein complex]] | ||
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[[Category: unique register]] | [[Category: unique register]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 12:11:36 2008'' |
Revision as of 10:11, 20 March 2008
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| , resolution 2.2Å | |||||||
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| Ligands: | and | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
Crystal structure of the autoimmune MHC class II I-Au complexed with myelin basic protein 1-11 at 2.2A
Overview
Murine experimental allergic encephalomyelitis (EAE) is a useful model for the demyelinating, autoimmune disease multiple sclerosis. In the EAE system, the immunodominant N-terminal epitope of myelin basic protein (MBP) is an unusually short, weakly binding peptide antigen which elicits highly biased TCR chain usage. In the 2.2 A crystal structure of I-A(u)/MBP1-11 complex, only MBP residues 1-7 are bound toward one end of the peptide binding cleft. The fourth residue of MBP1-11 is located in an incompatible p6 pocket of I-A(u), thus explaining the short half-life of I-A(u) complexed with Ac1-11. MBP peptides extended at the C terminus of Ac1-11 result in dramatic affinity increases, likely attributed to register shifting to a higher affinity cryptic epitope, which could potentially mask the presentation of the immunodominant MBP1-11 peptide during thymic education.
About this Structure
1K2D is a Protein complex structure of sequences from Mus musculus. Full crystallographic information is available from OCA.
Reference
Structural snapshot of aberrant antigen presentation linked to autoimmunity: the immunodominant epitope of MBP complexed with I-Au., He XL, Radu C, Sidney J, Sette A, Ward ES, Garcia KC, Immunity. 2002 Jul;17(1):83-94. PMID:12150894
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