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| - | [[Image:1cx0.gif|left|200px]] | + | #REDIRECT [[4pr6]] This PDB entry is obsolete and replaced by 4pr6 |
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| - | {{Structure
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| - | |PDB= 1cx0 |SIZE=350|CAPTION= <scene name='initialview01'>1cx0</scene>, resolution 2.30Å
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| - | |SITE=
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| - | |LIGAND= <scene name='pdbligand=A:ADENOSINE-5'-MONOPHOSPHATE'>A</scene>, <scene name='pdbligand=C:CYTIDINE-5'-MONOPHOSPHATE'>C</scene>, <scene name='pdbligand=G:GUANOSINE-5'-MONOPHOSPHATE'>G</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene>, <scene name='pdbligand=U:URIDINE-5'-MONOPHOSPHATE'>U</scene>
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| - | |ACTIVITY=
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| - | |GENE=
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| - | |DOMAIN=
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| - | |RELATEDENTRY=[[1drz|1DRZ]]
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| - | |RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1cx0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1cx0 OCA], [http://www.ebi.ac.uk/pdbsum/1cx0 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1cx0 RCSB]</span>
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| - | }}
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| - | '''HEPATITIS DELTA VIRUS RIBOZYME'''
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| - | ==Overview==
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| - | The self-cleaving ribozyme of the hepatitis delta virus (HDV) is the only catalytic RNA known to be required for the viability of a human pathogen. We obtained crystals of a 72-nucleotide, self-cleaved form of the genomic HDV ribozyme that diffract X-rays to 2.3 A resolution by engineering the RNA to bind a small, basic protein without affecting ribozyme activity. The co-crystal structure shows that the compact catalytic core comprises five helical segments connected as an intricate nested double pseudoknot. The 5'-hydroxyl leaving group resulting from the self-scission reaction is buried deep within an active-site cleft produced by juxtaposition of the helices and five strand-crossovers, and is surrounded by biochemically important backbone and base functional groups in a manner reminiscent of protein enzymes.
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| - | ==About this Structure==
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| - | 1CX0 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Hepatitis_delta_virus Hepatitis delta virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1CX0 OCA].
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| - | ==Reference==
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| - | Crystal structure of a hepatitis delta virus ribozyme., Ferre-D'Amare AR, Zhou K, Doudna JA, Nature. 1998 Oct 8;395(6702):567-74. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/9783582 9783582]
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| - | [[Category: Hepatitis delta virus]]
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| - | [[Category: Single protein]]
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| - | [[Category: Amare, A R.Ferre-D.]]
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| - | [[Category: Doudna, J A.]]
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| - | [[Category: Zhou, K.]]
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| - | [[Category: nested double pseudoknot rna structure]]
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| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 19:30:17 2008''
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