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| - | [[Image:1cx0.gif|left|200px]] | + | #REDIRECT [[4pr6]] This PDB entry is obsolete and replaced by 4pr6 |
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| - | {{STRUCTURE_1cx0| PDB=1cx0 | SCENE= }}
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| - | '''HEPATITIS DELTA VIRUS RIBOZYME'''
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| - | ==Overview==
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| - | The self-cleaving ribozyme of the hepatitis delta virus (HDV) is the only catalytic RNA known to be required for the viability of a human pathogen. We obtained crystals of a 72-nucleotide, self-cleaved form of the genomic HDV ribozyme that diffract X-rays to 2.3 A resolution by engineering the RNA to bind a small, basic protein without affecting ribozyme activity. The co-crystal structure shows that the compact catalytic core comprises five helical segments connected as an intricate nested double pseudoknot. The 5'-hydroxyl leaving group resulting from the self-scission reaction is buried deep within an active-site cleft produced by juxtaposition of the helices and five strand-crossovers, and is surrounded by biochemically important backbone and base functional groups in a manner reminiscent of protein enzymes.
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| - | ==About this Structure==
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| - | 1CX0 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Hepatitis_delta_virus Hepatitis delta virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1CX0 OCA].
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| - | ==Reference==
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| - | Crystal structure of a hepatitis delta virus ribozyme., Ferre-D'Amare AR, Zhou K, Doudna JA, Nature. 1998 Oct 8;395(6702):567-74. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/9783582 9783582]
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| - | [[Category: Hepatitis delta virus]]
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| - | [[Category: Single protein]]
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| - | [[Category: Amare, A R.Ferre-D.]]
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| - | [[Category: Doudna, J A.]]
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| - | [[Category: Zhou, K.]]
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| - | [[Category: Nested double pseudoknot rna structure]]
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| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 13:12:18 2008''
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