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2yps
From Proteopedia
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| - | ''' | + | ==Crystal structure of the PX domain of human sorting nexin 3== |
| - | + | <StructureSection load='2yps' size='340' side='right' caption='[[2yps]], [[Resolution|resolution]] 2.60Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[2yps]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2YPS OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2YPS FirstGlance]. <br> | |
| - | + | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2yps FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2yps OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2yps RCSB], [http://www.ebi.ac.uk/pdbsum/2yps PDBsum]</span></td></tr> | |
| - | + | </table> | |
| - | + | == Disease == | |
| + | [[http://www.uniprot.org/uniprot/SNX3_HUMAN SNX3_HUMAN]] MMEP syndrome. The gene represented in this entry may be involved in disease pathogenesis. A chromosomal aberration involving SNX3 has been found in patients with syndromic microphthalmia. Translocation t(6;13)(q21;q12). | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/SNX3_HUMAN SNX3_HUMAN]] Phosphoinositide-binding protein required for multivesicular body formation. Specifically binds phosphatidylinositol 3-phosphate (PtdIns(P3)). Plays a role in protein transport between cellular compartments. Promotes stability and cell surface expression of epithelial sodium channel (ENAC) subunits SCNN1A and SCNN1G (By similarity). Not involved in EGFR degradation.<ref>PMID:11433298</ref> <ref>PMID:18767904</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Arrowsmith, C H.]] | ||
| + | [[Category: Bountra, C.]] | ||
| + | [[Category: Canning, P.]] | ||
| + | [[Category: Delft, F von.]] | ||
| + | [[Category: Edwards, A M.]] | ||
| + | [[Category: Froese, D S.]] | ||
| + | [[Category: Kiyani, W.]] | ||
| + | [[Category: Krojer, T.]] | ||
| + | [[Category: Strain-Damerell, C.]] | ||
| + | [[Category: Yue, W W.]] | ||
| + | [[Category: Endosome]] | ||
| + | [[Category: Protein transport]] | ||
Revision as of 11:50, 29 October 2014
Crystal structure of the PX domain of human sorting nexin 3
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