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1ken

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[[Image:1ken.gif|left|200px]]<br /><applet load="1ken" size="350" color="white" frame="true" align="right" spinBox="true"
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[[Image:1ken.gif|left|200px]]
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caption="1ken, resolution 3.50&Aring;" />
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'''INFLUENZA VIRUS HEMAGGLUTININ COMPLEXED WITH AN ANTIBODY THAT PREVENTS THE HEMAGGLUTININ LOW PH FUSOGENIC TRANSITION'''<br />
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{{Structure
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|PDB= 1ken |SIZE=350|CAPTION= <scene name='initialview01'>1ken</scene>, resolution 3.50&Aring;
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|SITE=
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|LIGAND=
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|ACTIVITY=
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|GENE=
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}}
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'''INFLUENZA VIRUS HEMAGGLUTININ COMPLEXED WITH AN ANTIBODY THAT PREVENTS THE HEMAGGLUTININ LOW PH FUSOGENIC TRANSITION'''
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==Overview==
==Overview==
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==About this Structure==
==About this Structure==
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1KEN is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Influenza_a_virus Influenza a virus] and [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1KEN OCA].
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1KEN is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Influenza_a_virus Influenza a virus] and [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1KEN OCA].
==Reference==
==Reference==
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An antibody that prevents the hemagglutinin low pH fusogenic transition., Barbey-Martin C, Gigant B, Bizebard T, Calder LJ, Wharton SA, Skehel JJ, Knossow M, Virology. 2002 Mar 1;294(1):70-4. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=11886266 11886266]
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An antibody that prevents the hemagglutinin low pH fusogenic transition., Barbey-Martin C, Gigant B, Bizebard T, Calder LJ, Wharton SA, Skehel JJ, Knossow M, Virology. 2002 Mar 1;294(1):70-4. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/11886266 11886266]
[[Category: Influenza a virus]]
[[Category: Influenza a virus]]
[[Category: Mus musculus]]
[[Category: Mus musculus]]
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[[Category: hemagglutinin]]
[[Category: hemagglutinin]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 13:33:15 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 12:16:25 2008''

Revision as of 10:16, 20 March 2008

Image:1ken.gif


PDB ID 1ken

Drag the structure with the mouse to rotate
, resolution 3.50Å
Coordinates: save as pdb, mmCIF, xml



INFLUENZA VIRUS HEMAGGLUTININ COMPLEXED WITH AN ANTIBODY THAT PREVENTS THE HEMAGGLUTININ LOW PH FUSOGENIC TRANSITION


Overview

We have determined the structure of a complex of influenza hemagglutinin (HA) with an antibody that binds simultaneously to the membrane-distal domains of two HA monomers, effectively cross-linking them. The antibody prevents the low pH structural transition of HA that is required for its membrane fusion activity, providing evidence that a rearrangement of HA membrane-distal domains is an essential component of the transition.

About this Structure

1KEN is a Protein complex structure of sequences from Influenza a virus and Mus musculus. Full crystallographic information is available from OCA.

Reference

An antibody that prevents the hemagglutinin low pH fusogenic transition., Barbey-Martin C, Gigant B, Bizebard T, Calder LJ, Wharton SA, Skehel JJ, Knossow M, Virology. 2002 Mar 1;294(1):70-4. PMID:11886266

Page seeded by OCA on Thu Mar 20 12:16:25 2008

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