1kn4

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[[Image:1kn4.gif|left|200px]]<br /><applet load="1kn4" size="350" color="white" frame="true" align="right" spinBox="true"
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[[Image:1kn4.gif|left|200px]]
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caption="1kn4, resolution 1.90&Aring;" />
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'''CATALYTIC ANTIBODY D2.3 COMPLEX'''<br />
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{{Structure
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|PDB= 1kn4 |SIZE=350|CAPTION= <scene name='initialview01'>1kn4</scene>, resolution 1.90&Aring;
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|SITE=
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|LIGAND= <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene> and <scene name='pdbligand=PDE:PARA-NITROPHENYL PHOSPHONOBUTANOYL D-ALANINE'>PDE</scene>
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|ACTIVITY=
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|GENE=
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}}
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'''CATALYTIC ANTIBODY D2.3 COMPLEX'''
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==Overview==
==Overview==
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==About this Structure==
==About this Structure==
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1KN4 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus] with <scene name='pdbligand=ZN:'>ZN</scene> and <scene name='pdbligand=PDE:'>PDE</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1KN4 OCA].
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1KN4 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1KN4 OCA].
==Reference==
==Reference==
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Remarkable remote chiral recognition in a reaction mediated by a catalytic antibody., D'Souza LJ, Gigant B, Knossow M, Green BS, J Am Chem Soc. 2002 Mar 13;124(10):2114-5. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=11878955 11878955]
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Remarkable remote chiral recognition in a reaction mediated by a catalytic antibody., D'Souza LJ, Gigant B, Knossow M, Green BS, J Am Chem Soc. 2002 Mar 13;124(10):2114-5. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/11878955 11878955]
[[Category: Mus musculus]]
[[Category: Mus musculus]]
[[Category: Single protein]]
[[Category: Single protein]]
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[[Category: transition state analog]]
[[Category: transition state analog]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 13:35:59 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 12:19:38 2008''

Revision as of 10:19, 20 March 2008

Image:1kn4.gif


PDB ID 1kn4

Drag the structure with the mouse to rotate
, resolution 1.90Å
Ligands: and
Coordinates: save as pdb, mmCIF, xml



CATALYTIC ANTIBODY D2.3 COMPLEX


Overview

The crystal structures of catalytic antibody D2.3 Fab with the two enantiomers, 7D and 7L, which represent transition state analogues for the hydrolysis of the corresponding esters, 6D and 6L, were determined to better understand remarkable reactivity differences: the L-ester displayed significantly tighter binding (K(M)) and increased catalytic activity (k(cat)) with D2.3, even though the chiral center is 7 bonds distant from the reaction center. Surprisingly, the electron densities of the liganded phosphonates, 7D and 7L, within the D2.3 binding/reaction site were essentially identical, highlighting the subtle influences of protein interactions on chemical behavior.

About this Structure

1KN4 is a Single protein structure of sequence from Mus musculus. Full crystallographic information is available from OCA.

Reference

Remarkable remote chiral recognition in a reaction mediated by a catalytic antibody., D'Souza LJ, Gigant B, Knossow M, Green BS, J Am Chem Soc. 2002 Mar 13;124(10):2114-5. PMID:11878955

Page seeded by OCA on Thu Mar 20 12:19:38 2008

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