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Acid phosphatase

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'''Acid phosphatase''' (ACP, EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.3.2 3.1.3.2]) is an enzyme which removes phosphate from other molecules during digestion. It catalyzes the conversion of orthophosphoric monoester and H<sub>2</sub>O to alcohol and phosphoric acid. The enzyme is most effective in acidic environment. Prostatic ACP (PSAP) is produced by the prostate. It is found in increased amounts in patients who have prostate cancer. Purple ACP (PAP) contain a dinuclear Fe center and their oxidized for in solution maintains a purple color. Histidine ACP (HAP) catalyze the transfer of phosphoryl group using an active-site histidine.
'''Acid phosphatase''' (ACP, EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.3.2 3.1.3.2]) is an enzyme which removes phosphate from other molecules during digestion. It catalyzes the conversion of orthophosphoric monoester and H<sub>2</sub>O to alcohol and phosphoric acid. The enzyme is most effective in acidic environment. Prostatic ACP (PSAP) is produced by the prostate. It is found in increased amounts in patients who have prostate cancer. Purple ACP (PAP) contain a dinuclear Fe center and their oxidized for in solution maintains a purple color. Histidine ACP (HAP) catalyze the transfer of phosphoryl group using an active-site histidine.
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</StructureSection>
== 3D Structures of acid phosphatase ==
== 3D Structures of acid phosphatase ==
Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
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{{#tree:id=OrganizedByTopic|openlevels=0|
-
===Acid phosphatase===
+
*Acid phosphatase
-
[[1qfx]] – ACP – ''Aspergillus niger''<br />
+
**[[1qfx]] – ACP – ''Aspergillus niger''<br />
-
[[1dkm]], [[1dkn]] – EcACP (mutant) + Hg – ''Escherichia coli''<br />
+
**[[1dkm]], [[1dkn]] – EcACP (mutant) + Hg – ''Escherichia coli''<br />
-
[[1dkl]] – EcACP<br />
+
**[[1dkl]] – EcACP<br />
-
[[1n8n]] – EcACP-B + Au3<br />
+
**[[1n8n]] – EcACP-B + Au3<br />
-
[[1n9k]], [[3cz4]] - EcACP-B + Mg<br />
+
**[[1n9k]], [[3cz4]] - EcACP-B + Mg<br />
-
[[1rmt]] - EcACP-B + adenosine + Mg<br />
+
**[[1rmt]] - EcACP-B + adenosine + Mg<br />
-
[[1rmq]] - EcACP-B + Co + Os<br />
+
**[[1rmq]] - EcACP-B + Co + Os<br />
-
[[1dko]] - EcACP (mutant) + Hg + WO4<BR />
+
**[[1dko]] - EcACP (mutant) + Hg + WO4<BR />
-
[[2heg]] - EcACP-B + Mg + aspartate-BeF3<br />
+
**[[2heg]] - EcACP-B + Mg + aspartate-BeF3<br />
-
[[2hf7]] - EcACP-B + Mg + AlF3<br />
+
**[[2hf7]] - EcACP-B + Mg + AlF3<br />
-
[[1d2t]] - EbACP – ''Escherichia blattae''<br />
+
**[[1d2t]] - EbACP – ''Escherichia blattae''<br />
-
[[1iw8]] - EbACP (mutant) <br />
+
**[[1iw8]] - EbACP (mutant) <br />
-
[[1eoi]] – EbACP + MoO4<BR />
+
**[[1eoi]] – EbACP + MoO4<BR />
-
[[2akc]] - StACP-A + WO4 - ''Salmonella typhimurium''<br />
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**[[2akc]] - StACP-A + WO4 - ''Salmonella typhimurium''<br />
-
[[2p4u]] – mACP1 + phosphate – mouse<br />
+
**[[2p4u]] – mACP1 + phosphate – mouse<br />
-
[[2gfh]] – mACP acetylneuraminic<br />
+
**[[2gfh]] – mACP acetylneuraminic<br />
-
[[2i33]] – BaACP-C + Mg – ''Bacillus anthracis''<br />
+
**[[2i33]] – BaACP-C + Mg – ''Bacillus anthracis''<br />
-
[[2i34]] - BaACP-C + Mg + WO4<BR />
+
**[[2i34]] - BaACP-C + Mg + WO4<BR />
-
[[3pct]] – ACP-C – ''Pasteurella multocida''<BR />
+
**[[3pct]] – ACP-C – ''Pasteurella multocida''<BR />
-
[[3et4]], [[3et5]] – HiACP – ''Haemophilus influenzae''<br />
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**[[3et4]], [[3et5]] – HiACP – ''Haemophilus influenzae''<br />
-
''Acid phosphatase complex with phosphate derivative''
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*Acid phosphatase complex with phosphate derivative
-
[[2b82]] - EcACP-B + adenosine + Mg + phosphate<br />
+
**[[2b82]] - EcACP-B + adenosine + Mg + phosphate<br />
-
[[2b8j]] - EcACP-B + adenosine + Mg + spermine + Au3 + phosphate<br />
+
**[[2b8j]] - EcACP-B + adenosine + Mg + spermine + Au3 + phosphate<br />
-
[[1rmy]] - EcACP-B + Mg + deoxycytidine + phosphate<br />
+
**[[1rmy]] - EcACP-B + Mg + deoxycytidine + phosphate<br />
-
[[2g1a]] - EcACP-B + Mg + phosphonic acid derivative<br />
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**[[2g1a]] - EcACP-B + Mg + phosphonic acid derivative<br />
-
[[1dkp]], [[1dkq]] - EcACP (mutant) + Hg + inositol hexakisphosphate<br />
+
**[[1dkp]], [[1dkq]] - EcACP (mutant) + Hg + inositol hexakisphosphate<br />
-
[[2a96]] – StACP-A + phosphate<br />
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**[[2a96]] – StACP-A + phosphate<br />
-
[[3ocu]] – HiACP (mutant) + nicotineamide mononucleotide<br />
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**[[3ocu]] – HiACP (mutant) + nicotineamide mononucleotide<br />
-
[[3ocv]], [[3ocw]], [[3ocx]], [[3sf0]] - HiACP (mutant) + AMP<br />
+
**[[3ocv]], [[3ocw]], [[3ocx]], [[3sf0]] - HiACP (mutant) + AMP<br />
-
[[3ocy]] - HiACP + phosphate<br />
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**[[3ocy]] - HiACP + phosphate<br />
-
[[3ocz]] - HiACP + AMP derivative
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**[[3ocz]] - HiACP + AMP derivative
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===Histidine acid phosphatase===
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*Histidine acid phosphatase
-
[[2d1g]] – FtHAP-A + VO4 – ''Francisella tularensis''<br />
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**[[2d1g]] – FtHAP-A + VO4 – ''Francisella tularensis''<br />
-
[[2ipb]] - FtHAP-A (mutant) <br />
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**[[2ipb]] - FtHAP-A (mutant) <br />
-
[[4e3w]] - FtHAP-A (mutant) + proline<br />
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**[[4e3w]] - FtHAP-A (mutant) + proline<br />
-
[[3it0]] - FtHAP-A + phosphate<br />
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**[[3it0]] - FtHAP-A + phosphate<br />
-
[[3it1]] - FtHAP-A + tartrate<br />
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**[[3it1]] - FtHAP-A + tartrate<br />
-
[[3it2]] - FtHAP-A <br />
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**[[3it2]] - FtHAP-A <br />
-
[[3it3]] - FtHAP-A (mutant) + 3’- AMP<br />
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**[[3it3]] - FtHAP-A (mutant) + 3’- AMP<br />
-
[[4ars]] – HaHAP-A – ''Hafnia alvei''<br />
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**[[4ars]] – HaHAP-A – ''Hafnia alvei''<br />
-
[[4aro]] – HaHAP-A (mutant) + myo-inositol hexakis sulfate <br />
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**[[4aro]] – HaHAP-A (mutant) + myo-inositol hexakis sulfate <br />
-
[[4aru]] - HaHAP-A + tartrate<br />
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**[[4aru]] - HaHAP-A + tartrate<br />
-
===Tyrosine acid phosphatase===
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*Tyrosine acid phosphatase
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[[1bvh]] – bYAP – bovine – NMR<br />
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**[[1bvh]] – bYAP – bovine – NMR<br />
-
[[1pnt]], [[1xww]] – bYAP<br />
+
**[[1pnt]], [[1xww]] – bYAP<br />
-
[[1z12]] – bYAP + VO4<br />
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**[[1z12]] – bYAP + VO4<br />
-
[[1z13]] – bYAP + MoO4
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**[[1z13]] – bYAP + MoO4
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===Prostate acid phosphatase===
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*Prostate acid phosphatase
-
[[1rpa]] – rPSAP + tartaric acid – rat<br />
+
**[[1rpa]] – rPSAP + tartaric acid – rat<br />
-
[[1rpt]] – rPSAP + VO4<BR />
+
**[[1rpt]] – rPSAP + VO4<BR />
-
[[2hpa]] – hPSAP + propyl tartramic acid – human<br />
+
**[[2hpa]] – hPSAP + propyl tartramic acid – human<br />
-
[[1cvi]] – hPSAP<br />
+
**[[1cvi]] – hPSAP<br />
-
[[2l3h]], [[2l77]], [[2l79]] – hPSAP residues 248-286 - NMR<br />
+
**[[2l3h]], [[2l77]], [[2l79]] – hPSAP residues 248-286 - NMR<br />
-
[[1nd5]], [[1nd6]] – hPSAP + inhibitor
+
**[[1nd5]], [[1nd6]] – hPSAP + inhibitor
-
===Purple acid phosphatase===
+
*Purple acid phosphatase
-
[[1kbp]], [[2qfp]], [[2qfr]] – PvPAP + Fe + Zn – ''Phaseolus vulgaris''<br />
+
**[[1kbp]], [[2qfp]], [[2qfr]] – PvPAP + Fe + Zn – ''Phaseolus vulgaris''<br />
-
[[3kbp]] - PvPAP + Fe + Zn + WO4<BR />
+
**[[3kbp]] - PvPAP + Fe + Zn + WO4<BR />
-
[[4kbp]] - PvPAP + Fe + Zn + phosphate<br />
+
**[[4kbp]] - PvPAP + Fe + Zn + phosphate<br />
-
[[2qfr]] - PvPAP + Fe + Zn + sulfate<br />
+
**[[2qfr]] - PvPAP + Fe + Zn + sulfate<br />
-
[[4dhl]], [[4dsy]], [[4dt2]] - PvPAP + Fe + Zn + thiazole derivative<br />
+
**[[4dhl]], [[4dsy]], [[4dt2]] - PvPAP + Fe + Zn + thiazole derivative<br />
-
[[1qhw]] - rPAP + Fe + Zn<br />
+
**[[1qhw]] - rPAP + Fe + Zn<br />
-
[[1qfc]] - rPAP + Fe + phosphate<br />
+
**[[1qfc]] - rPAP + Fe + phosphate<br />
-
[[1war]] – hPAP + Fe + phosphate<br />
+
**[[1war]] – hPAP + Fe + phosphate<br />
-
[[2bq8]] - hPAP + Fe + Zn<br />
+
**[[2bq8]] - hPAP + Fe + Zn<br />
-
[[1ute]] – PAP + μ-oxo-diiron – pig<br />
+
**[[1ute]] – PAP + μ-oxo-diiron – pig<br />
-
[[1xzw]] - PAP + Fe + Mn + phosphate – sweet potato
+
**[[1xzw]] - PAP + Fe + Mn + phosphate – sweet potato
-
===Acetylneuraminic acid phosphatase===
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*Acetylneuraminic acid phosphatase
-
 
+
-
[[2gfh]] – mNANP<br />
+
-
[[2w4m]] - hNANP
+
 +
**[[2gfh]] – mNANP<br />
 +
**[[2w4m]] - hNANP
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}}
[[Category:Topic Page]]
[[Category:Topic Page]]

Revision as of 09:23, 12 November 2014

Template:STRUCTURE 1dkm

Acid phosphatase (ACP, EC number 3.1.3.2) is an enzyme which removes phosphate from other molecules during digestion. It catalyzes the conversion of orthophosphoric monoester and H2O to alcohol and phosphoric acid. The enzyme is most effective in acidic environment. Prostatic ACP (PSAP) is produced by the prostate. It is found in increased amounts in patients who have prostate cancer. Purple ACP (PAP) contain a dinuclear Fe center and their oxidized for in solution maintains a purple color. Histidine ACP (HAP) catalyze the transfer of phosphoryl group using an active-site histidine. </StructureSection>

3D Structures of acid phosphatase

Updated on 12-November-2014

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky, Joel L. Sussman

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