Androgen receptor
From Proteopedia
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| - | + | *AR DBD domain* | |
| - | [[1r4i]] – rAR (mutant) + DNA – rat<br /> | + | **[[1r4i]] – rAR (mutant) + DNA – rat<br /> |
| - | + | *AR LBD domain | |
| - | ''AR LBD domain complex with testosterone or DHT'' | + | *''AR LBD domain complex with testosterone or DHT'' |
| - | [[1i37]] – rAR + DHT <br /> | + | **[[1i37]] – rAR + DHT <br /> |
| - | [[1i38]] – rAR (mutant) + DHT <br /> | + | **[[1i38]] – rAR (mutant) + DHT <br /> |
| - | [[2ama]] – hAR + DHT - human<br /> | + | **[[2ama]] – hAR + DHT - human<br /> |
| - | [[1t7t]] – cAR + DHT - chimpanzee<br /> | + | **[[1t7t]] – cAR + DHT - chimpanzee<br /> |
| - | [[2ylo]], [[2ylp]], [[2ylq]], [[3zqt]], [[4hlw]] – hAR + testosterone + benzoate derivative<br /> | + | **[[2ylo]], [[2ylp]], [[2ylq]], [[3zqt]], [[4hlw]] – hAR + testosterone + benzoate derivative<br /> |
| - | [[2pio]], [[2pip]], [[2piq]], [[2pir]], [[2pit]], [[2piu]], [[2piv]], [[2piw]], [[2pix]], [[2pkl]], [[2qpy]] – hAR + DHT + small molecule<br /> | + | **[[2pio]], [[2pip]], [[2piq]], [[2pir]], [[2pit]], [[2piu]], [[2piv]], [[2piw]], [[2pix]], [[2pkl]], [[2qpy]] – hAR + DHT + small molecule<br /> |
| - | [[2yhd]] – hAR + testosterone + small molecule<br /> | + | **[[2yhd]] – hAR + testosterone + small molecule<br /> |
| - | [[2am9]] – rAR + testosterone <br /> | + | **[[2am9]] – rAR + testosterone <br /> |
| - | ''Other AR LBD domain complexes'' | + | *''Other AR LBD domain complexes'' |
| - | [[1e3g]], [[1xq3]] – hAR + androgen <br /> | + | **[[1e3g]], [[1xq3]] – hAR + androgen <br /> |
| - | [[1gs4]] – hAR (mutant) + corticosteroid<br /> | + | **[[1gs4]] – hAR (mutant) + corticosteroid<br /> |
| - | [[1z95]], [[3rlj]] – hAR + anti-androgen <br /> | + | **[[1z95]], [[3rlj]] – hAR + anti-androgen <br /> |
| - | [[2oz7]], [[3rll]] – hAR (mutant) + anti-androgen <br /> | + | **[[2oz7]], [[3rll]] – hAR (mutant) + anti-androgen <br /> |
| - | [[2ax6]], [[2ax7]], [[2ax8]] – hAR (mutant) + nonsteroidal ligand <br /> | + | **[[2ax6]], [[2ax7]], [[2ax8]] – hAR (mutant) + nonsteroidal ligand <br /> |
| - | [[2ax9]], [[2axa]] – hAR + nonsteroidal ligand <br /> | + | **[[2ax9]], [[2axa]] – hAR + nonsteroidal ligand <br /> |
| - | [[2amb]], [[2pnu]] – hAR + steroid <br /> | + | **[[2amb]], [[2pnu]] – hAR + steroid <br /> |
| - | [[1xnn]] – rAR (mutant) + nonsteroidal ligand <br /> | + | **[[1xnn]] – rAR (mutant) + nonsteroidal ligand <br /> |
| - | [[2ihq]], [[2nw4]], [[3g0w]] – rAR + modulator <br /> | + | **[[2ihq]], [[2nw4]], [[3g0w]] – rAR + modulator <br /> |
| - | [[2hvc]], [[3b5r]], [[3b65]], [[3b66]], [[3b67]], [[3b68]] – hAR + modulator <br /> | + | **[[2hvc]], [[3b5r]], [[3b65]], [[3b66]], [[3b67]], [[3b68]] – hAR + modulator <br /> |
| - | ''AR LBD domain complex with peptide'' | + | *''AR LBD domain complex with peptide'' |
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| + | **[[1t73]], [[1t74]], [[1t76]], [[1t79]], [[1t7f]], [[1t7m]], [[1t7r]] – cAR + FXXFF-type peptide <br /> | ||
| + | **[[1xow]] – hAR + androgen + FXXFF-type peptide <br /> | ||
| + | **[[3v49]], [[3v4a]] – hAR + modulator + FXXFF-type peptide <br /> | ||
| + | **[[1t5z]] – hAR + DHT + nuclear receptor coactivator 1 peptide<br /> | ||
| + | **[[1t63]], [[1t65]] – hAR + DHT + nuclear receptor coactivator 2 peptide<br /> | ||
| + | **[[3l3x]], [[3l3z]] – hAR + DHT + nuclear receptor coactivator 3 peptide<br /> | ||
| + | **[[2z4j]] – hAR + DHT + nuclear receptor 0B2 peptide<br /> | ||
| + | **[[2q7j]] – hAR + testosterone + nuclear receptor coactivator 2 peptide<br /> | ||
| + | **[[2q7k]], [[2q7l]] – hAR (mutant) + testosterone + nuclear receptor coactivator 2 peptide<br /> | ||
| + | **[[2ao6]] – hAR + nuclear receptor coactivator 2 peptide<br /> | ||
| + | **[[1xj7]] – hAR + DHT + RAC3 peptide<br /> | ||
| + | }} | ||
==See Also== | ==See Also== | ||
* [[Hormone]] | * [[Hormone]] | ||
[[Category:Topic Page]] | [[Category:Topic Page]] | ||
Revision as of 08:56, 17 November 2014
Androgen receptor (AR) is a nuclear receptor which is activated by testosterone or 5-α-dihydrotestosterone (DHT) hormone. Upon binding the androgenic hormone it translocates to the nucleus where it acts as a DNA-binding transcription factor. The AR binds to a specific sequence of DNA called hormone response element. AR binds to other proteins in the nucleus causing up- or down gene regulation. AR exists in two isoforms. AR-B is full length 110 kDa and AR-A (87 kDa) lacks the N-terminal 187 amino acids. AR structure is composed of 5 domains -
A/B: N-terminal contains the activation functions and dimerization surface
C: DNA binding domain (DBD)
D: Hinge region between DBD and LBD
E: Ligand binding domain (LBD) which binds the N-terminal FXXFL motif
F: C-terminal domain
3D Structures of androgen receptor
Updated on 17-November-2014
See Also
Proteopedia Page Contributors and Editors (what is this?)
Cristina Benito, Michal Harel, Cristina Murga, Marta Roldan Lazaro, Alexander Berchansky, Joel L. Sussman, Wayne Decatur, David Sánchez Fernández
