This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


Androgen receptor

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 13: Line 13:
Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
 +
{{#tree:id=OrganizedByTopic|openlevels=0|
-
===AR DBD domain===
+
*AR DBD domain*
-
[[1r4i]] – rAR (mutant) + DNA – rat<br />
+
**[[1r4i]] – rAR (mutant) + DNA – rat<br />
-
===AR LBD domain===
+
*AR LBD domain
-
''AR LBD domain complex with testosterone or DHT''
+
*''AR LBD domain complex with testosterone or DHT''
-
[[1i37]] – rAR + DHT <br />
+
**[[1i37]] – rAR + DHT <br />
-
[[1i38]] – rAR (mutant) + DHT <br />
+
**[[1i38]] – rAR (mutant) + DHT <br />
-
[[2ama]] – hAR + DHT - human<br />
+
**[[2ama]] – hAR + DHT - human<br />
-
[[1t7t]] – cAR + DHT - chimpanzee<br />
+
**[[1t7t]] – cAR + DHT - chimpanzee<br />
-
[[2ylo]], [[2ylp]], [[2ylq]], [[3zqt]], [[4hlw]] – hAR + testosterone + benzoate derivative<br />
+
**[[2ylo]], [[2ylp]], [[2ylq]], [[3zqt]], [[4hlw]] – hAR + testosterone + benzoate derivative<br />
-
[[2pio]], [[2pip]], [[2piq]], [[2pir]], [[2pit]], [[2piu]], [[2piv]], [[2piw]], [[2pix]], [[2pkl]], [[2qpy]] – hAR + DHT + small molecule<br />
+
**[[2pio]], [[2pip]], [[2piq]], [[2pir]], [[2pit]], [[2piu]], [[2piv]], [[2piw]], [[2pix]], [[2pkl]], [[2qpy]] – hAR + DHT + small molecule<br />
-
[[2yhd]] – hAR + testosterone + small molecule<br />
+
**[[2yhd]] – hAR + testosterone + small molecule<br />
-
[[2am9]] – rAR + testosterone <br />
+
**[[2am9]] – rAR + testosterone <br />
-
''Other AR LBD domain complexes''
+
*''Other AR LBD domain complexes''
-
[[1e3g]], [[1xq3]] – hAR + androgen <br />
+
**[[1e3g]], [[1xq3]] – hAR + androgen <br />
-
[[1gs4]] – hAR (mutant) + corticosteroid<br />
+
**[[1gs4]] – hAR (mutant) + corticosteroid<br />
-
[[1z95]], [[3rlj]] – hAR + anti-androgen <br />
+
**[[1z95]], [[3rlj]] – hAR + anti-androgen <br />
-
[[2oz7]], [[3rll]] – hAR (mutant) + anti-androgen <br />
+
**[[2oz7]], [[3rll]] – hAR (mutant) + anti-androgen <br />
-
[[2ax6]], [[2ax7]], [[2ax8]] – hAR (mutant) + nonsteroidal ligand <br />
+
**[[2ax6]], [[2ax7]], [[2ax8]] – hAR (mutant) + nonsteroidal ligand <br />
-
[[2ax9]], [[2axa]] – hAR + nonsteroidal ligand <br />
+
**[[2ax9]], [[2axa]] – hAR + nonsteroidal ligand <br />
-
[[2amb]], [[2pnu]] – hAR + steroid <br />
+
**[[2amb]], [[2pnu]] – hAR + steroid <br />
-
[[1xnn]] – rAR (mutant) + nonsteroidal ligand <br />
+
**[[1xnn]] – rAR (mutant) + nonsteroidal ligand <br />
-
[[2ihq]], [[2nw4]], [[3g0w]] – rAR + modulator <br />
+
**[[2ihq]], [[2nw4]], [[3g0w]] – rAR + modulator <br />
-
[[2hvc]], [[3b5r]], [[3b65]], [[3b66]], [[3b67]], [[3b68]] – hAR + modulator <br />
+
**[[2hvc]], [[3b5r]], [[3b65]], [[3b66]], [[3b67]], [[3b68]] – hAR + modulator <br />
-
''AR LBD domain complex with peptide''
+
*''AR LBD domain complex with peptide''
-
 
+
-
[[1t73]], [[1t74]], [[1t76]], [[1t79]], [[1t7f]], [[1t7m]], [[1t7r]] – cAR + FXXFF-type peptide <br />
+
-
[[1xow]] – hAR + androgen + FXXFF-type peptide <br />
+
-
[[2q7i]] – hAR + testosterone + FXXFF-type peptide <br />
+
-
[[3v49]], [[3v4a]] – hAR + modulator + FXXFF-type peptide <br />
+
-
[[1t5z]] – hAR + DHT + nuclear receptor coactivator 1 peptide<br />
+
-
[[1t63]], [[1t65]] – hAR + DHT + nuclear receptor coactivator 2 peptide<br />
+
-
[[3l3x]], [[3l3z]] – hAR + DHT + nuclear receptor coactivator 3 peptide<br />
+
-
[[2z4j]] – hAR + DHT + nuclear receptor 0B2 peptide<br />
+
-
[[2q7j]] – hAR + testosterone + nuclear receptor coactivator 2 peptide<br />
+
-
[[2q7k]], [[2q7l]] – hAR (mutant) + testosterone + nuclear receptor coactivator 2 peptide<br />
+
-
[[2ao6]] – hAR + nuclear receptor coactivator 2 peptide<br />
+
-
[[1xj7]] – hAR + DHT + RAC3 peptide<br />
+
 +
**[[1t73]], [[1t74]], [[1t76]], [[1t79]], [[1t7f]], [[1t7m]], [[1t7r]] – cAR + FXXFF-type peptide <br />
 +
**[[1xow]] – hAR + androgen + FXXFF-type peptide <br />
 +
**[[3v49]], [[3v4a]] – hAR + modulator + FXXFF-type peptide <br />
 +
**[[1t5z]] – hAR + DHT + nuclear receptor coactivator 1 peptide<br />
 +
**[[1t63]], [[1t65]] – hAR + DHT + nuclear receptor coactivator 2 peptide<br />
 +
**[[3l3x]], [[3l3z]] – hAR + DHT + nuclear receptor coactivator 3 peptide<br />
 +
**[[2z4j]] – hAR + DHT + nuclear receptor 0B2 peptide<br />
 +
**[[2q7j]] – hAR + testosterone + nuclear receptor coactivator 2 peptide<br />
 +
**[[2q7k]], [[2q7l]] – hAR (mutant) + testosterone + nuclear receptor coactivator 2 peptide<br />
 +
**[[2ao6]] – hAR + nuclear receptor coactivator 2 peptide<br />
 +
**[[1xj7]] – hAR + DHT + RAC3 peptide<br />
 +
}}
==See Also==
==See Also==
* [[Hormone]]
* [[Hormone]]
[[Category:Topic Page]]
[[Category:Topic Page]]

Revision as of 08:56, 17 November 2014


Template:STRUCTURE 2q7i

Androgen receptor (AR) is a nuclear receptor which is activated by testosterone or 5-α-dihydrotestosterone (DHT) hormone. Upon binding the androgenic hormone it translocates to the nucleus where it acts as a DNA-binding transcription factor. The AR binds to a specific sequence of DNA called hormone response element. AR binds to other proteins in the nucleus causing up- or down gene regulation. AR exists in two isoforms. AR-B is full length 110 kDa and AR-A (87 kDa) lacks the N-terminal 187 amino acids. AR structure is composed of 5 domains -
A/B: N-terminal contains the activation functions and dimerization surface
C: DNA binding domain (DBD)
D: Hinge region between DBD and LBD
E: Ligand binding domain (LBD) which binds the N-terminal FXXFL motif
F: C-terminal domain

3D Structures of androgen receptor

Updated on 17-November-2014

See Also

Retrieved from "http://52.214.119.220/wiki/index.php/Androgen_receptor"
Personal tools