1vw4

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{{Large structure}}
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==Structure of the yeast mitochondrial large ribosomal subunit==
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{{STRUCTURE_1vw4| PDB=1vw4 | SCENE= }}
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<StructureSection load='1vw4' size='340' side='right' caption='[[1vw4]], [[Resolution|resolution]] 3.20&Aring;' scene=''>
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===Structure of the yeast mitochondrial large ribosomal subunit===
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== Structural highlights ==
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{{ABSTRACT_PUBMED_24675956}}
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<table><tr><td colspan='2'>[[1vw4]] is a 36 chain structure with sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1VW4 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1VW4 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3j6b|3j6b]], [[1vw3|1vw3]]</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1vw4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1vw4 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1vw4 RCSB], [http://www.ebi.ac.uk/pdbsum/1vw4 PDBsum]</span></td></tr>
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</table>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Mitochondria have specialized ribosomes that have diverged from their bacterial and cytoplasmic counterparts. We have solved the structure of the yeast mitoribosomal large subunit using single-particle cryo-electron microscopy. The resolution of 3.2 angstroms enabled a nearly complete atomic model to be built de novo and refined, including 39 proteins, 13 of which are unique to mitochondria, as well as expansion segments of mitoribosomal RNA. The structure reveals a new exit tunnel path and architecture, unique elements of the E site, and a putative membrane docking site.
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==Function==
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Structure of the yeast mitochondrial large ribosomal subunit.,Amunts A, Brown A, Bai XC, Llacer JL, Hussain T, Emsley P, Long F, Murshudov G, Scheres SH, Ramakrishnan V Science. 2014 Mar 28;343(6178):1485-9. doi: 10.1126/science.1249410. PMID:24675956<ref>PMID:24675956</ref>
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[[http://www.uniprot.org/uniprot/RM06_YEAST RM06_YEAST]] Indispensable for mitochondrial function. [[http://www.uniprot.org/uniprot/RM36_YEAST RM36_YEAST]] Involved in mitochondrial translation. Overexpression suppresses mutations in the COX2 leader peptide-encoding and initiation codon regions.<ref>PMID:11259585</ref> <ref>PMID:15166137</ref> [[http://www.uniprot.org/uniprot/RTC6_YEAST RTC6_YEAST]] Probable component of the mitochondrial large ribosomal subunit involved in ribosome biogenesis and translation. May be involved in a process influencing telomere capping.<ref>PMID:9392081</ref> <ref>PMID:18845848</ref> <ref>PMID:20691087</ref> [[http://www.uniprot.org/uniprot/MHR1_YEAST MHR1_YEAST]] Transcription factor involved in regulation of RNA polymerase II-dependent transcription. Also involved in regulation of mitochondrial DNA recombination, maintenance and repair, and generation of homoplasmic cells.<ref>PMID:11121487</ref> <ref>PMID:9736700</ref> <ref>PMID:7664749</ref> <ref>PMID:12198175</ref> <ref>PMID:12034822</ref> <ref>PMID:14565971</ref> <ref>PMID:16337661</ref> [[http://www.uniprot.org/uniprot/IMG1_YEAST IMG1_YEAST]] Essential for respiration.<ref>PMID:8771712</ref>
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==About this Structure==
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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[[1vw4]] is a 36 chain structure with sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1VW4 OCA].
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</div>
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== References ==
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==Reference==
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<references/>
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<ref group="xtra">PMID:024675956</ref><references group="xtra"/><references/>
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__TOC__
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</StructureSection>
[[Category: Saccharomyces cerevisiae]]
[[Category: Saccharomyces cerevisiae]]
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[[Category: Amunts, A.]]
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[[Category: Amunts, A]]
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[[Category: Bai, X C.]]
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[[Category: Bai, X C]]
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[[Category: Brown, A.]]
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[[Category: Brown, A]]
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[[Category: Emsley, P.]]
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[[Category: Emsley, P]]
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[[Category: Hussain, T.]]
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[[Category: Hussain, T]]
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[[Category: Llacer, J L.]]
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[[Category: Llacer, J L]]
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[[Category: Long, F.]]
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[[Category: Long, F]]
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[[Category: Murshudov, G.]]
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[[Category: Murshudov, G]]
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[[Category: Ramakrishnan, V.]]
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[[Category: Ramakrishnan, V]]
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[[Category: Scheres, S H.W.]]
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[[Category: Scheres, S H.W]]
[[Category: Large subunit]]
[[Category: Large subunit]]
[[Category: Mitochondrial ribosome]]
[[Category: Mitochondrial ribosome]]
[[Category: Protein-rna complex]]
[[Category: Protein-rna complex]]
[[Category: Ribosome]]
[[Category: Ribosome]]

Revision as of 09:45, 19 November 2014

Structure of the yeast mitochondrial large ribosomal subunit

1vw4, resolution 3.20Å

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