Cephalosporin acylase

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Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
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{{#tree:id=OrganizedByTopic|openlevels=0|
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[[2nlz]] - CSA – ''Bacillus halodurans''<br />
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[[1fm2]] - BdCSA – ''Brevundimonas diminuta''<br />
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[[1gk0]], [[1gk1]], [[1ghd]] - PsCSA – ''Pseudomonas''<br />
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[[2ae3]], [[2ae5]] - PsCSA α + β (mutant) subunits<br />
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[[2ae4]], [[4e55]], [[4e56]], [[4e57]] - PsCSA α (mutant) + β subunits<br />
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[[1keh]] - BdCSA precursor (mutant)
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===Cephalosporin acylase complex===
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*Cephalosporin acylase
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**[[2nlz]] - CSA – ''Bacillus halodurans''<br />
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**[[1fm2]] - BdCSA – ''Brevundimonas diminuta''<br />
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**[[1gk0]], [[1gk1]], [[1ghd]] - PsCSA – ''Pseudomonas''<br />
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**[[2ae3]], [[2ae5]] - PsCSA α + β (mutant) subunits<br />
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**[[2ae4]], [[4e55]], [[4e56]], [[4e57]] - PsCSA α (mutant) + β subunits<br />
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**[[1keh]] - BdCSA precursor (mutant)
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[[1jvz]] – BdCSA + glutaryl-7-ACA<br />
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*Cephalosporin acylase complex
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[[1jw0]] - BdCSA + glutarate
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**[[1jvz]] – BdCSA + glutaryl-7-ACA<br />
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**[[1jw0]] - BdCSA + glutarate
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[[Category:Topic Page]]
[[Category:Topic Page]]

Revision as of 09:26, 20 November 2014

Template:STRUCTURE 1jvz

Cephalosporin acylase (CSA) catalyzes the conversion of cephalosporin C (CPC) to 7-amino-cephalosporanic acid (7-ACA). CSA contains 2 non-identical subunits. CSA is used commercially for production of semi-synthetic cephalosporin antibiotics. The active site pocket of CSA is similar to that of penicillin acylase. CSA precursor is cleaved at 2 sites forming the active heterodimer.

3D structures of cephalosporin acylase

Updated on 20-November-2014

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky

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