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1lnl

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[[Image:1lnl.gif|left|200px]]<br /><applet load="1lnl" size="350" color="white" frame="true" align="right" spinBox="true"
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[[Image:1lnl.gif|left|200px]]
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caption="1lnl, resolution 3.30&Aring;" />
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'''Structure of deoxygenated hemocyanin from Rapana thomasiana'''<br />
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{{Structure
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|PDB= 1lnl |SIZE=350|CAPTION= <scene name='initialview01'>1lnl</scene>, resolution 3.30&Aring;
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|SITE=
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|LIGAND= <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene> and <scene name='pdbligand=CU:COPPER (II) ION'>CU</scene>
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|ACTIVITY=
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|GENE=
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}}
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'''Structure of deoxygenated hemocyanin from Rapana thomasiana'''
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==Overview==
==Overview==
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==About this Structure==
==About this Structure==
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1LNL is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Rapana_thomasiana Rapana thomasiana] with <scene name='pdbligand=NAG:'>NAG</scene> and <scene name='pdbligand=CU:'>CU</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1LNL OCA].
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1LNL is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Rapana_thomasiana Rapana thomasiana]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1LNL OCA].
==Reference==
==Reference==
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The structure of a functional unit from the wall of a gastropod hemocyanin offers a possible mechanism for cooperativity., Perbandt M, Guthohrlein EW, Rypniewski W, Idakieva K, Stoeva S, Voelter W, Genov N, Betzel C, Biochemistry. 2003 Jun 3;42(21):6341-6. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=12767214 12767214]
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The structure of a functional unit from the wall of a gastropod hemocyanin offers a possible mechanism for cooperativity., Perbandt M, Guthohrlein EW, Rypniewski W, Idakieva K, Stoeva S, Voelter W, Genov N, Betzel C, Biochemistry. 2003 Jun 3;42(21):6341-6. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/12767214 12767214]
[[Category: Rapana thomasiana]]
[[Category: Rapana thomasiana]]
[[Category: Single protein]]
[[Category: Single protein]]
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[[Category: oxygen]]
[[Category: oxygen]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 13:46:34 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 12:32:58 2008''

Revision as of 10:32, 20 March 2008

Image:1lnl.gif


PDB ID 1lnl

Drag the structure with the mouse to rotate
, resolution 3.30Å
Ligands: and
Coordinates: save as pdb, mmCIF, xml



Structure of deoxygenated hemocyanin from Rapana thomasiana


Overview

Structure-function relationships in a molluscan hemocyanin have been investigated by determining the crystal structure of the Rapana thomasiana (gastropod) hemocyanin functional unit RtH2e in deoxygenated form at 3.38 A resolution. This is the first X-ray structure of an unit from the wall of the molluscan hemocyanin cylinder. The crystal structure of RtH2e demonstrates molecular self-assembly of six identical molecules forming a regular hexameric cylinder. This suggests how the functional units are ordered in the wall of the native molluscan hemocyanins. The molecular arrangement is stabilized by specific protomer-to-protomer interactions, which are probably typical for the functional units building the wall of the cylinders. A molecular mechanism for cooperative dioxygen binding in molluscan hemocyanins is proposed on the basis of the molecular interactions between the protomers. In particular, the deoxygenated RtH2e structure reveals a tunnel leading from two opposite sides of the molecule to the active site. The tunnel represents a possible entrance pathway for dioxygen molecules. No such tunnels have been observed in the crystal structure of the oxy-Odg, a functional unit from the Octopus dofleini (cephalopod) hemocyanin in oxygenated form.

About this Structure

1LNL is a Single protein structure of sequence from Rapana thomasiana. Full crystallographic information is available from OCA.

Reference

The structure of a functional unit from the wall of a gastropod hemocyanin offers a possible mechanism for cooperativity., Perbandt M, Guthohrlein EW, Rypniewski W, Idakieva K, Stoeva S, Voelter W, Genov N, Betzel C, Biochemistry. 2003 Jun 3;42(21):6341-6. PMID:12767214

Page seeded by OCA on Thu Mar 20 12:32:58 2008

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