DNA glycosylase

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m (DNA glycosylate moved to DNA glycosylase: requested by Editor)
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{{#tree:id=OrganizedByTopic|openlevels=0|
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===Adenine DG===
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*Adenine DG
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[[3n5n]] – hADG catalytic domain – human<BR />
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**[[3n5n]] – hADG catalytic domain – human<BR />
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[[1yuo]] - hADG catalytic domain (mutant) <BR />
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**[[1yuo]] - hADG catalytic domain (mutant) <BR />
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[[1x51]] – hADG NUDIX domain - NMR<BR />
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**[[1x51]] – hADG NUDIX domain - NMR<BR />
-
[[3fsp]], [[3fsq]] – GsADG + DNA – ''Geobacillus stearothermophilus''<BR />
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**[[3fsp]], [[3fsq]] – GsADG + DNA – ''Geobacillus stearothermophilus''<BR />
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[[3g0q]], [[1vrl]], [[1rrq]], [[1rrs]] - GsADG (mutant) + DNA – ''Bacillus stearothermophilus''<BR />
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**[[3g0q]], [[1vrl]], [[1rrq]], [[1rrs]] - GsADG (mutant) + DNA – ''Bacillus stearothermophilus''<BR />
-
[[1wef]], [[1weg]], [[1kg4]], [[1kg5]], [[1kg6]], [[1kg7]], [[1kqj]] - EcADG catalytic domain (mutant) - ''Escherichia coli''<BR />
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**[[1wef]], [[1weg]], [[1kg4]], [[1kg5]], [[1kg6]], [[1kg7]], [[1kqj]] - EcADG catalytic domain (mutant) - ''Escherichia coli''<BR />
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[[1kg2]], [[1kg3]], [[1muy]] - EcADG catalytic domain<BR />
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**[[1kg2]], [[1kg3]], [[1muy]] - EcADG catalytic domain<BR />
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[[1mun]] - EcADG catalytic domain (mutant) <BR />
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**[[1mun]] - EcADG catalytic domain (mutant) <BR />
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[[1wei]], [[1mud]] - EcADG catalytic domain (mutant) + adenine
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**[[1wei]], [[1mud]] - EcADG catalytic domain (mutant) + adenine
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===Uracil DG===
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*Uracil DG
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[[3a7n]] – MtUDG – ''Mycobacterium tuberculosis''<BR />
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**[[3a7n]] – MtUDG – ''Mycobacterium tuberculosis''<BR />
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[[2zhx]] – MtDG + protein inhibitor<BR />
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**[[2zhx]] – MtDG + protein inhibitor<BR />
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[[1akz]] - hUDG (mutant) <BR />
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**[[1akz]] - hUDG (mutant) <BR />
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[[2oxm]], [[2oyt]], [[1q3f]] – hUDG + DNA<BR />
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**[[2oxm]], [[2oyt]], [[1q3f]] – hUDG + DNA<BR />
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[[1ssp]], [[2ssp]] - hUDG + DNA+ uracil<BR />
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**[[1ssp]], [[2ssp]] - hUDG + DNA+ uracil<BR />
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[[1emh]], [[1emj]], [[4skn]] – hUDG (mutant) + DNA<BR />
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**[[1emh]], [[1emj]], [[4skn]] – hUDG (mutant) + DNA<BR />
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[[3fcf]], [[3fci]], [[3fck]], [[3fcl]], [[2hxm]] – hUDG + inhibitor<BR />
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**[[3fcf]], [[3fci]], [[3fck]], [[3fcl]], [[2hxm]] – hUDG + inhibitor<BR />
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[[1ugh]] - hUDG (mutant) + protein inhibitor<BR />
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**[[1ugh]] - hUDG (mutant) + protein inhibitor<BR />
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[[2jhq]] – UDG – ''Vibrio cholerae''<BR />
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**[[2jhq]] – UDG – ''Vibrio cholerae''<BR />
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[[3cxm]] – UDG residues 129-373 + 5-bromo-uracil<BR />
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**[[3cxm]] – UDG residues 129-373 + 5-bromo-uracil<BR />
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[[2owq]], [[2owr]] – UDG (mutant) – Vaccinia virus<BR />
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**[[2owq]], [[2owr]] – UDG (mutant) – Vaccinia virus<BR />
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[[2d3y]], [[1ui0]], [[1ui1]] – TtUDG – ''Thermus thermophilus''<BR />
+
**[[2d3y]], [[1ui0]], [[1ui1]] – TtUDG – ''Thermus thermophilus''<BR />
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[[2dp6]], [[2dem]], [[2ddg]] – TtUDG + DNA<BR />
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**[[2dp6]], [[2dem]], [[2ddg]] – TtUDG + DNA<BR />
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[[2j8x]] – UDG glycosylase domain + protein inhibitor – Epstein-Barr virus<BR />
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**[[2j8x]] – UDG glycosylase domain + protein inhibitor – Epstein-Barr virus<BR />
-
[[1lqj]] – EcUDG<BR />
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**[[1lqj]] – EcUDG<BR />
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[[1flz]] - EcUDG (mutant) <BR />
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**[[1flz]] - EcUDG (mutant) <BR />
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[[2eug]], [[3eug]], [[1eug]], [[4eug]], [[5eug]] - EcUDG (mutant) + uracil<BR />
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**[[2eug]], [[3eug]], [[1eug]], [[4eug]], [[5eug]] - EcUDG (mutant) + uracil<BR />
-
[[1mwj]], [[1mwi]], [[1mtl]] – EcUDG + DNA<BR />
+
**[[1mwj]], [[1mwi]], [[1mtl]] – EcUDG + DNA<BR />
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[[1lqg]], [[1lqm]], [[1eui]], [[1uug]] - EcUDG + protein inhibitor<BR />
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**[[1lqg]], [[1lqm]], [[1eui]], [[1uug]] - EcUDG + protein inhibitor<BR />
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[[2uug]] - EcUDG (mutant) + protein inhibitor<BR />
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**[[2uug]] - EcUDG (mutant) + protein inhibitor<BR />
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[[2c53]], [[2c56]] – HhUDG (mutant) – Human herpesvirus<BR />
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**[[2c53]], [[2c56]] – HhUDG (mutant) – Human herpesvirus<BR />
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[[1lau]] – HhUDG + DNA<BR />
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**[[1lau]] – HhUDG + DNA<BR />
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[[1udh]], [[1udg]] – HsUDG _ Herpes simplex virus<BR />
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**[[1udh]], [[1udg]] – HsUDG _ Herpes simplex virus<BR />
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[[1udi]] - HsUDG + protein inhibitor<BR />
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**[[1udi]] - HsUDG + protein inhibitor<BR />
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[[2c2p]], [[2boo]] – DrUDG – ''Deinococcus radiodurans''<BR />
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**[[2c2p]], [[2boo]] – DrUDG – ''Deinococcus radiodurans''<BR />
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[[2c2q]] – DrUDG (mutant) <BR />
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**[[2c2q]] – DrUDG (mutant) <BR />
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[[1vk2]], [[1l9g]] – TmUDG - ''Thermotoga maritime''<BR />
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**[[1vk2]], [[1l9g]] – TmUDG - ''Thermotoga maritime''<BR />
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[[1okb]] – UDG catalytic domain – Atlantic cod
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**[[1okb]] – UDG catalytic domain – Atlantic cod
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===Smug1 Uracil DG===
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*Smug1 Uracil DG
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[[1oe4]], [[1oe5]], [[1oe6]] – UDG Smug1 + DNA– ''Xenopus laevis''
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**[[1oe4]], [[1oe5]], [[1oe6]] – UDG Smug1 + DNA– ''Xenopus laevis''
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===Thymine DG===
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*Thymine DG
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[[2rba]] – hTDG core domain + DNA<BR />
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**[[2rba]] – hTDG core domain + DNA<BR />
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[[2d07]], [[1wyw]] – hTDG central region + SUMO-3<BR />
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**[[2d07]], [[1wyw]] – hTDG central region + SUMO-3<BR />
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[[1kea]] – TDG – ''Methanothermobacter thermautotrophicus''<BR />
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**[[1kea]] – TDG – ''Methanothermobacter thermautotrophicus''<BR />
-
[[1mug]] – EcTDG
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**[[1mug]] – EcTDG
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===Human 8-oxoguanine DG===
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*Human 8-oxoguanine DG
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[[1ko9]] – hOgg1<BR />
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**[[1ko9]] – hOgg1<BR />
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[[2xhi]], [[3ktu]], [[1hu0]], [[1fn7]] - hOgg1 + DNA<BR />
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**[[2xhi]], [[3ktu]], [[1hu0]], [[1fn7]] - hOgg1 + DNA<BR />
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[[1lwv]], [[1lww]], [[1lwy]] - hOgg1 + DNA<BR /> + guanine derivative<BR />
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**[[1lwv]], [[1lww]], [[1lwy]] - hOgg1 + DNA<BR /> + guanine derivative<BR />
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[[2nob]], [[2noe]], [[2nof]], [[2noh]], [[2noi]], [[2nol]], [[2noz]], [[2i5w]], [[1yqk]], [[1yql]], [[1yqm]], [[1yqr]], [[1n39]], [[1n3a]], [[1n3c]] - hOgg1 (mutant) + DNA<BR />
+
**[[2nob]], [[2noe]], [[2nof]], [[2noh]], [[2noi]], [[2nol]], [[2noz]], [[2i5w]], [[1yqk]], [[1yql]], [[1yqm]], [[1yqr]], [[1n39]], [[1n3a]], [[1n3c]] - hOgg1 (mutant) + DNA<BR />
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[[1m3h]], [[3ih7]] - hOgg1 core fragment (mutant) + DNA<BR />
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**[[1m3h]], [[3ih7]] - hOgg1 core fragment (mutant) + DNA<BR />
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[[1m3q]], [[1ebm]] - hOgg1 core fragment (mutant) + DNA + guanine derivative
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**[[1m3q]], [[1ebm]] - hOgg1 core fragment (mutant) + DNA + guanine derivative
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===8-oxoguanine (oxoG) DG===
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*8-oxoguanine (oxoG) DG
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[[3n0u]] – TmOxDG<BR />
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**[[3n0u]] – TmOxDG<BR />
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[[3knt]] - MjOxDG (mutant) + DNA – ''Methanocaldococcus jannaschii''<BR />
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**[[3knt]] - MjOxDG (mutant) + DNA – ''Methanocaldococcus jannaschii''<BR />
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[[3fhf]] - MjOxDG<BR />
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**[[3fhf]] - MjOxDG<BR />
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[[3go8]], [[3gp1]], [[3gpp]], [[3gpu]], [[3gpx]], [[3gpy]], [[3gq3]], [[3gq4]], [[3gq5]] – GsOxDG (mutant) + DNA<BR />
+
**[[3go8]], [[3gp1]], [[3gpp]], [[3gpu]], [[3gpx]], [[3gpy]], [[3gq3]], [[3gq4]], [[3gq5]] – GsOxDG (mutant) + DNA<BR />
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[[3f0z]] - CaOxDG – ''Clostridium acetobutylicum''<BR />
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**[[3f0z]] - CaOxDG – ''Clostridium acetobutylicum''<BR />
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[[3f10]] – CaOxDG + oxoG<BR />
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**[[3f10]] – CaOxDG + oxoG<BR />
-
[[3i0w]], [[3i0x]] - CaOxDG (mutant) + DNA<BR />
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**[[3i0w]], [[3i0x]] - CaOxDG (mutant) + DNA<BR />
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[[3fhg]] - OxDG (mutant) – ''Sulfolobus solfataricus''<BR />
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**[[3fhg]] - OxDG (mutant) – ''Sulfolobus solfataricus''<BR />
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[[1xqo]], [[1xqp]] – OxDG – ''Pyrobaculum aerophilum''<br />
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**[[1xqo]], [[1xqp]] – OxDG – ''Pyrobaculum aerophilum''<br />
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[[4ejy]], [[4ejz]] – OxDG + DNA – ''Thermoanaerobacter tengcongensis''<br />
+
**[[4ejy]], [[4ejz]] – OxDG + DNA – ''Thermoanaerobacter tengcongensis''<br />
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===Methyladenine DG===
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*Methyladenine DG
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[[3qi5]], [[1ewn]], [[1f4r]], [[1f6o]], [[1bnk]] – hAlkDG + DNA<BR />
+
**[[3qi5]], [[1ewn]], [[1f4r]], [[1f6o]], [[1bnk]] – hAlkDG + DNA<BR />
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[[3bvs]] – BcAlkDG – ''Bacillus cereus''<BR />
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**[[3bvs]] – BcAlkDG – ''Bacillus cereus''<BR />
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[[3jx7]], [[3jxy]], [[3jxz]], [[3jy1]] - BcAlkDG + DNA<BR />
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**[[3jx7]], [[3jxy]], [[3jxz]], [[3jy1]] - BcAlkDG + DNA<BR />
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[[1pvs]], [[1p7m]], [[1mpg]] – EcAlkDG<BR />
+
**[[1pvs]], [[1p7m]], [[1mpg]] – EcAlkDG<BR />
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[[1nku]], [[1lmz]] – EcAlkDG - NMR<BR />
+
**[[1nku]], [[1lmz]] – EcAlkDG - NMR<BR />
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[[3ogd]], [[3oh6]], [[3oh9]] - EcAlkDG (mutant) + DNA<BR />
+
**[[3ogd]], [[3oh6]], [[3oh9]] - EcAlkDG (mutant) + DNA<BR />
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[[3d4v]], [[3cvs]], [[3cvt]], [[3cw7]], [[3cwa]], [[3cws]], [[3cwt]], [[3cwu]], [[1diz]] - EcAlkDG + DNA<BR />
+
**[[3d4v]], [[3cvs]], [[3cvt]], [[3cw7]], [[3cwa]], [[3cws]], [[3cwt]], [[3cwu]], [[1diz]] - EcAlkDG + DNA<BR />
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[[2ofk]] – StAlkDG – ''Salmonella typhi''<BR />
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**[[2ofk]] – StAlkDG – ''Salmonella typhi''<BR />
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[[2ofi]] – StAlkDG + DNA<BR />
+
**[[2ofi]] – StAlkDG + DNA<BR />
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[[2jhj]], [[2jhn]] – AlkDG – ''Archaeoglobus fulgidus''<BR />
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**[[2jhj]], [[2jhn]] – AlkDG – ''Archaeoglobus fulgidus''<BR />
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[[2jg6]] – AlkDG – ''Staphylococcus aureus''<BR />
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**[[2jg6]] – AlkDG – ''Staphylococcus aureus''<BR />
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[[1pu6]] – HpAlkDG – ''Helicobacter pylori''<BR />
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**[[1pu6]] – HpAlkDG – ''Helicobacter pylori''<BR />
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[[1pu7]], [[1pu8]] – HpAlkDG + adenine derivative
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**[[1pu7]], [[1pu8]] – HpAlkDG + adenine derivative
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===Formamidopyrimidine DG===
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*Formamidopyrimidine DG
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[[1ee8]] – TtFpg <br />
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**[[1ee8]] – TtFpg <br />
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[[3a42]], [[3a45]] – ApFpg – ''Acanthamoeba polyphaga'' minivirus<br />
+
**[[3a42]], [[3a45]] – ApFpg – ''Acanthamoeba polyphaga'' minivirus<br />
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[[3twk]], [[3twl]] – AtFpg - ''Arabidopsis thaliana''<br />
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**[[3twk]], [[3twl]] – AtFpg - ''Arabidopsis thaliana''<br />
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''Fpg complex with DNA''
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*''Fpg complex with DNA''
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[[1k82]] – EcFpg + DNA <br />
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**[[1k82]] – EcFpg + DNA <br />
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[[1kfv]], [[1nnj]] – LlFpg (mutant) + DNA – ''Lactococcus lactis''<br />
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**[[1kfv]], [[1nnj]] – LlFpg (mutant) + DNA – ''Lactococcus lactis''<br />
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[[1l1t]], [[1l1z]], [[1l2b]], [[1l2c]] – GsFpg + DNA <br />
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**[[1l1t]], [[1l1z]], [[1l2b]], [[1l2c]] – GsFpg + DNA <br />
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[[2f5n]], [[2f5o]], [[2f5p]], [[3gpx]], [[3gq5]] – GsFpg (mutant) + DNA <br />
+
**[[2f5n]], [[2f5o]], [[2f5p]], [[3gpx]], [[3gq5]] – GsFpg (mutant) + DNA <br />
-
''Fpg complex with DNA containing a damaged base''
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*''Fpg complex with DNA containing a damaged base''
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[[1r2y]], [[2f5q]], [[2f5s]], [[3jr5]], [[3gp1]], [[3gpp]], [[3gpu]], [[3gpy]], [[3gq3]], [[3gq4]], [[3go8]], [[3u6c]], [[3u6d]] – GsFpg (mutant) + DNA containing oxoG<br />
+
**[[1r2y]], [[2f5q]], [[2f5s]], [[3jr5]], [[3gp1]], [[3gpp]], [[3gpu]], **[[3gpy]], [[3gq3]], [[3gq4]], [[3go8]], [[3u6c]], [[3u6d]] – GsFpg (mutant) + DNA containing oxoG<br />
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[[3u6e]], [[4g4o]], [[4g4r]] – GsFpg (mutant) + DNA containing oxoG and thymidine derivative <br />
+
**[[3u6e]], [[4g4o]], [[4g4r]] – GsFpg (mutant) + DNA containing oxoG and thymidine derivative <br />
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[[3u6l]], [[3u6m]], [[3u6q]] – GsFpg (mutant) + DNA containing oxoG and cytidine derivative <br />
+
**[[3u6l]], [[3u6m]], [[3u6q]] – GsFpg (mutant) + DNA containing oxoG and cytidine derivative <br />
-
[[1r2z]] – GsFpg (mutant) + DNA containing 5,6-dihydrouracil<br />
+
**[[1r2z]] – GsFpg (mutant) + DNA containing 5,6-dihydrouracil<br />
-
[[3saw]] – GsFpg + DNA containing cytidine derivative<br />
+
**[[3saw]] – GsFpg + DNA containing cytidine derivative<br />
-
[[3sar]], [[3sav]], [[3sbj]] – GsFpg (mutant) + DNA containing cytidine derivative<br />
+
**[[3sar]], [[3sav]], [[3sbj]] – GsFpg (mutant) + DNA containing cytidine derivative<br />
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[[1l2d]], [[3sau]], [[3u6o]], [[3u6p]], [[3u6s]], [[4g4n]], [[4g4q]] – GsFpg (mutant) + DNA containing thymidine derivative<br />
+
**[[1l2d]], [[3sau]], [[3u6o]], [[3u6p]], [[3u6s]], [[4g4n]], [[4g4q]] – GsFpg (mutant) + DNA containing thymidine derivative<br />
-
[[3sas]], [[3sat]] – GsFpg (mutant) + DNA containing open deoxy-ribofuranose phosphate <br />
+
**[[3sas]], [[3sat]] – GsFpg (mutant) + DNA containing open deoxy-ribofuranose phosphate <br />
-
[[1pm5]] – LlFpg + DNA containing abasic dideoxyribose<br />
+
**[[1pm5]] – LlFpg + DNA containing abasic dideoxyribose<br />
-
[[1pjj]] – LlFpg (mutant) + DNA containing abasic dideoxyribose<br />
+
**[[1pjj]] – LlFpg (mutant) + DNA containing abasic dideoxyribose<br />
-
[[4cis]] – LlFpg + DNA containing oxoG derivative<br />
+
**[[4cis]] – LlFpg + DNA containing oxoG derivative<br />
-
[[3twm]] – AtFpg + DNA containing abasic dideoxyribose<br />
+
**[[3twm]] – AtFpg + DNA containing abasic dideoxyribose<br />
-
[[1pji]] – LlFpg + DNA containing 1,3-propanediol<br />
+
**[[1pji]] – LlFpg + DNA containing 1,3-propanediol<br />
-
[[2xzf]], [[2xzu]] – LlFpg + DNA containing oxidized pyrimidine<br />
+
**[[2xzf]], [[2xzu]] – LlFpg + DNA containing oxidized pyrimidine<br />
-
[[1tdz]], [[1xc8]], [[3c58]] – LlFpg + DNA containing Fapy-dG derivative<br />
+
**[[1tdz]], [[1xc8]], [[3c58]] – LlFpg + DNA containing Fapy-dG derivative<br />
-
[[3a46]] – ApFpg + DNA containing abasic dideoxyribose<br />
+
**[[3a46]] – ApFpg + DNA containing abasic dideoxyribose<br />
-
[[4nrw]] – ApFpg (mutant) + DNA containing abasic dideoxyribose<br />
+
**[[4nrw]] – ApFpg (mutant) + DNA containing abasic dideoxyribose<br />
-
[[3vk7]] – ApFpg (mutant) + DNA containing 5-hydroxyuracil <br />
+
**[[3vk7]] – ApFpg (mutant) + DNA containing 5-hydroxyuracil <br />
-
[[3vk8]] – ApFpg (mutant) + DNA containing thymine glycol<br />
+
**[[3vk8]] – ApFpg (mutant) + DNA containing thymine glycol<br />
-
[[3jr4]] – GsFpg (mutant) + DNA + guanosine derivative <br /
+
**[[3jr4]] – GsFpg (mutant) + DNA + guanosine derivative <br />
-
===DNA glycosylase NEI===
+
*DNA glycosylase NEI
-
[[2ea0]], [[2opf]], [[2oq4]], [[1k3w]], [[1k3x]] – EcGD NEI + DNA<BR />
+
**[[2ea0]], [[2opf]], [[2oq4]], [[1k3w]], [[1k3x]] – EcGD NEI + DNA<BR />
-
[[2fcc]] – Pyrimidine GD + DNA – Enterobacteria phage T4<br />
+
**[[2fcc]] – Pyrimidine GD + DNA – Enterobacteria phage T4<br />
-
[[1q39]] – EcGD NEI<br />
+
**[[1q39]] – EcGD NEI<br />
-
[[1q3b]], [[1q3c]] – EcGD NEI (mutant)<br />
+
**[[1q3b]], [[1q3c]] – EcGD NEI (mutant)<br />
-
[[1tdh]] – hGD NEI
+
**[[1tdh]] – hGD NEI
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[[Category:Topic Page]]
+
}}

Revision as of 09:00, 24 November 2014

Image:1akz.png
Crystal Structure of DNA glycosylate, 1akz

Template:STRUCTURE 3fsp











DNA glycosylase (DG) are enzymes which remove damaged DNA bases by flipping them out of the double helix followed by their cleavage. Monofunctional DG have only glycosylase activity; bifunctional DG also act as lysates; ADG, UDG, TDG remove adenine, uracil, thymine from DNA.

  • Adenine DNA glycosylase is also called MutY.
  • Smug1 is a single-strand selective monofunctional UDG.
  • 8-oxoguanine DNA glycosylase recognize oxidized bases.
  • Human 8-oxoguanine GD is named hOgg1. See details on Ogg1 in 8-Oxoguanine Glycosylase.
  • AlkDG recognize methylated adenine; for details see Alka1.
  • Formamidopyrimidine DG (FPG) or MutM or Fapy-DNA glycosylase removes oxidized purines from damaged DNA. More about FPG in
  • Fpg Nei Protein Family
  • Fpg Nei Protein Superfamily.

3D Structures of DNA glycosylate

Updated on 24-November-2014

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky, Joel L. Sussman, Jaime Prilusky

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