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EPSP synthase

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The enzyme has <scene name='57/570585/Two_domains/1'>two domains</scene>, with the active site found in the interdomain cleft. There is a substantial structural change upon substrate binding, resulting in a <scene name='57/570585/Closed_formation/1'>closed formation</scene>. Glyphosate (also known as Roundup) occupies the binding site of the second substrate, phosphoenol pyruvate.
The enzyme has <scene name='57/570585/Two_domains/1'>two domains</scene>, with the active site found in the interdomain cleft. There is a substantial structural change upon substrate binding, resulting in a <scene name='57/570585/Closed_formation/1'>closed formation</scene>. Glyphosate (also known as Roundup) occupies the binding site of the second substrate, phosphoenol pyruvate.
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</StructureSection>
===3D structures of EPSP synthase ===
===3D structures of EPSP synthase ===
Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
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{{#tree:id=OrganizedByTopic|openlevels=0|
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[[1eps]] – EcEPSP – ''Escherichia coli''<br />
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*5-enolpyruvylshikimate 3-phosphate (EPSP) synthase
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[[1p88]], [[1p89]] - EcEPSP N terminal - NMR<br />
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-
[[1rf5]] - SpEPSP – ''Streptococcus pneumoniae''<br />
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-
[[2bjb]], [[2o15]] – MtEPSP – ''Mycobacterium tuberculosis''<br />
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-
[[2gg4]] – AgEPSP – ''Agrobacterium''<br />
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-
[[3roi]], [[3tr1]], [[4gfp]] – CbEPSP – ''Coxiella burnetii''<br />
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-
[[3ti2]] - VcEPSP N terminal – ''Vibrio cholerae''<br />
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===EPSP synthase binary complex===
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**[[1eps]] – EcEPSP – ''Escherichia coli''<br />
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**[[1p88]], [[1p89]] - EcEPSP N terminal - NMR<br />
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**[[1rf5]] - SpEPSP – ''Streptococcus pneumoniae''<br />
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**[[2bjb]], [[2o15]] – MtEPSP – ''Mycobacterium tuberculosis''<br />
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**[[2gg4]] – AgEPSP – ''Agrobacterium''<br />
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**[[3roi]], [[3tr1]], [[4gfp]] – CbEPSP – ''Coxiella burnetii''<br />
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**[[3ti2]] - VcEPSP N terminal – ''Vibrio cholerae''<br />
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[[1g6t]] - EcEPSP + S3P <br />
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*EPSP synthase binary complex
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[[1mi4]], [[2qfq]], [[2qfs]], [[3fjx]], [[3fk0]] - EcEPSP (mutant) + S3P <br />
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[[1q36]] - EcEPSP (mutant) + S3P derivative<br />
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-
[[1x8r]], [[1x8t]] - EcEPSP + intermediate <br />
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-
[[2aa9]] – EcEPSP + shikimate<br />
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-
[[2pq9]] - EcEPSP + intermediate <br />
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-
[[1rf4]] - SpEPSP + intermediate <br />
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-
[[2o0b]], [[2o0d]] - MtEPSP + S3P <br />
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-
[[2gg6]] - AgEPSP + S3P <br />
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-
[[2pqb]], [[2pqc]], [[2pqd]] - AgEPSP + intermediate <br />
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-
[[2o0x]] - MtEPSP + intermediate <br />
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[[2o0z]] - MtEPSP + EPS <br />
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[[4egr]] - CbEPSP + phosphoenolpyruvate<br />
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===EPSP synthase ternary complex===
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**[[1g6t]] - EcEPSP + S3P <br />
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**[[1mi4]], [[2qfq]], [[2qfs]], [[3fjx]], [[3fk0]] - EcEPSP (mutant) + S3P <br />
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**[[1q36]] - EcEPSP (mutant) + S3P derivative<br />
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**[[1x8r]], [[1x8t]] - EcEPSP + intermediate <br />
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**[[2aa9]] – EcEPSP + shikimate<br />
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**[[2pq9]] - EcEPSP + intermediate <br />
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**[[1rf4]] - SpEPSP + intermediate <br />
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**[[2o0b]], [[2o0d]] - MtEPSP + S3P <br />
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**[[2gg6]] - AgEPSP + S3P <br />
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**[[2pqb]], [[2pqc]], [[2pqd]] - AgEPSP + intermediate <br />
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**[[2o0x]] - MtEPSP + intermediate <br />
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**[[2o0z]] - MtEPSP + EPS <br />
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**[[4egr]] - CbEPSP + phosphoenolpyruvate<br />
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[[1g6p]] - EcEPSP + S3P + glyphosate<br />
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*EPSP synthase ternary complex
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[[2qft]], [[2qfu]], [[3fjz]], [[3fk1]] - EcEPSP (mutant) + S3P + glyphosate<br />
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[[2aay]] - EcEPSP + shikimate + glyphosate<br />
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[[1rf6]] - SpEPSP + S3P + glyphosate<br />
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[[2gga]] - AgEPSP + S3P + glyphosate<br />
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[[4ggd]] - AgEPSP (mutant) + S3P + glyphosate<br />
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[[2o0e]] - MtEPSP + S3P + phosphoenolpyruvate<br />
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[[3nvs]] - VcEPSP + S3P + glyphosate <br />
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-
[[3slh]] - CbEPSP + S3P + glyphosate<br />
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**[[1g6p]] - EcEPSP + S3P + glyphosate<br />
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**[[2qft]], [[2qfu]], [[3fjz]], [[3fk1]] - EcEPSP (mutant) + S3P + glyphosate<br />
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**[[2aay]] - EcEPSP + shikimate + glyphosate<br />
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**[[1rf6]] - SpEPSP + S3P + glyphosate<br />
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**[[2gga]] - AgEPSP + S3P + glyphosate<br />
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**[[4ggd]] - AgEPSP (mutant) + S3P + glyphosate<br />
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**[[2o0e]] - MtEPSP + S3P + phosphoenolpyruvate<br />
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**[[3nvs]] - VcEPSP + S3P + glyphosate <br />
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**[[3slh]] - CbEPSP + S3P + glyphosate<br />
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}}
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</StructureSection>
 
[[Category:Topic Page]]
[[Category:Topic Page]]

Revision as of 11:44, 24 November 2014

Structure of EPSP Synthase

Structure of EPSP synthase (PDB entry 1eps)

Drag the structure with the mouse to rotate

3D structures of EPSP synthase

Updated on 24-November-2014

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky, Ann Taylor, Joel L. Sussman

Retrieved from "http://52.214.119.220/wiki/index.php/EPSP_synthase"
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