Factor inhibiting HIF

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Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
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{{#tree:id=OrganizedByTopic|openlevels=0|
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===FIH1α===
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*FIH1α
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[[1mze]], [[1h2n]], [[1iz3]] – hFIH1α – human
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**[[1mze]], [[1h2n]], [[1iz3]] – hFIH1α – human
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===FIH1α complex with small molecule===
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*FIH1α complex with small molecule
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[[1yci]], [[3od4]], [[2yc0]], [[2yde]]– hFIH1α + inhibitor<br />
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**[[1yci]], [[3od4]], [[2yc0]], [[2yde] – hFIH1α + inhibitor<br />
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[[2w0x]] - hFIH1α + pyridine derivative<br />
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**[[2w0x]] - hFIH1α + pyridine derivative<br />
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[[2cgn]] – hFIH1α + succinate<br />
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**[[2cgn]] – hFIH1α + succinate<br />
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[[2cgo]] – hFIH1α + fumarate<br />
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**[[2cgo]] – hFIH1α + fumarate<br />
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[[1mzf]], [[2wa3]], [[2wa4]], [[2yc0]], [[2yde]] – hFIH1α + oxoglutarate derivative<br />
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**[[1mzf]], [[2wa3]], [[2wa4]], [[2yc0]], [[2yde]] – hFIH1α + oxoglutarate derivative<br />
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[[3kcx]], [[3kcy]], [[3od4]], [[4bio]] - hFIH1α + quinol derivative<br />
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**[[3kcx]], [[3kcy]], [[3od4]], [[4bio]] - hFIH1α + quinol derivative<br />
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[[4ai8]] - hFIH1α + daminozide<br />
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**[[4ai8]] - hFIH1α + daminozide<br />
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===FIH1α complex with polypeptide===
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*FIH1α complex with polypeptide
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[[1h2k]], [[1h2l]], [[1h2m]] – hFIH1α + HIF transactivation domain peptide<br />
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**[[1h2k]], [[1h2l]], [[1h2m]] – hFIH1α + HIF transactivation domain peptide<br />
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[[2ilm]], [[3d8c]] - hFIH1α (mutant) + HIF peptide + α-ketoglutarate<br />
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**[[2ilm]], [[3d8c]] - hFIH1α (mutant) + HIF peptide + α-ketoglutarate<br />
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[[3p3n]], [[3p3p]] - hFIH1α + Notch 1 peptide<br />
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**[[3p3n]], [[3p3p]] - hFIH1α + Notch 1 peptide<br />
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[[2xum]] - hFIH1α (mutant) + Asp-substrate peptide + oxoglutarate derivative<br />
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**[[2xum]] - hFIH1α (mutant) + Asp-substrate peptide + oxoglutarate derivative<br />
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[[2y0i]] - hFIH1α + tankyrase 2 peptide<br />
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**[[2y0i]] - hFIH1α + tankyrase 2 peptide<br />
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[[3hqr]], [[3hqu]] - hFIH 1α C terminal + EGL nine homolog<br />
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**[[3hqr]], [[3hqu]] - hFIH 1α C terminal + EGL nine homolog<br />
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[[1lqb]], [[1lm8]] - hFIH 1α residues 549-582 + elongin B + elongin C + PVHL<br />
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**[[1lqb]], [[1lm8]] - hFIH 1α residues 549-582 + elongin B + elongin C + PVHL<br />
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[[1l3e]] - hFIH 1α C terminal + P300 Cys/His-rich domain – NMR<br />
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**[[1l3e]] - hFIH 1α C terminal + P300 Cys/His-rich domain – NMR<br />
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[[1l8c]] - hFIH 1α C terminal + CREB-binding protein zinc finger<br />
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**[[1l8c]] - hFIH 1α C terminal + CREB-binding protein zinc finger<br />
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[[4h6j]] - hFIH 1α PAS B domain (mutant) + aryl hydrocarbon nuclear translocator<br />
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**[[4h6j]] - hFIH 1α PAS B domain (mutant) + aryl hydrocarbon nuclear translocator<br />
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[[4b7e]], [[4b7k]], [[4jaa]] - hFIH1α + consensus ankyrin repeat peptide<br />
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**[[4b7e]], [[4b7k]], [[4jaa]] - hFIH1α + consensus ankyrin repeat peptide<br />
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===FIH2α===
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*FIH2α
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[[2a24]], [[3f1n]], [[3f1o]], [[3f1p]], [[3h7w]] - hFIH 2α PAS domain + hFIH 1β PAS domain<br />
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**[[2a24]], [[3f1n]], [[3f1o]], [[3f1p]], [[3h7w]] - hFIH 2α PAS domain + hFIH 1β PAS domain<br />
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[[3h82]] - hFIH 2α PAS domain (mutant) + hFIH 1β PAS domain (mutant)
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**[[3h82]] - hFIH 2α PAS domain (mutant) + hFIH 1β PAS domain (mutant)
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===FIH1β===
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*FIH1β
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[[2b02]], [[1x0o]] - hFIH 1β PAS domain<br />
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[[2hv1]], [[2k7s ]]- hFIH 1β PAS domain - NMR
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**[[2b02]], [[1x0o]] - hFIH 1β PAS domain<br />
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**[[2hv1]], [[2k7s ]]- hFIH 1β PAS domain - NMR
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}}
[[Category:Topic Page]]
[[Category:Topic Page]]

Revision as of 13:13, 24 November 2014

Template:STRUCTURE 1mzf

For details on Factor inhibiting HIF see Molecular Playground/FIH. HIF is hypoxia-inducible factor - transcription factors that respond to hypoxia, i.e., decrease in oxygen.

3D Structures of factor inhibiting HIF

Updated on 24-November-2014 {{#tree:id=OrganizedByTopic|openlevels=0|

  • FIH1α
  • FIH1α complex with small molecule
  • FIH1α complex with polypeptide
    • 1h2k, 1h2l, 1h2m – hFIH1α + HIF transactivation domain peptide
    • 2ilm, 3d8c - hFIH1α (mutant) + HIF peptide + α-ketoglutarate
    • 3p3n, 3p3p - hFIH1α + Notch 1 peptide
    • 2xum - hFIH1α (mutant) + Asp-substrate peptide + oxoglutarate derivative
    • 2y0i - hFIH1α + tankyrase 2 peptide
    • 3hqr, 3hqu - hFIH 1α C terminal + EGL nine homolog
    • 1lqb, 1lm8 - hFIH 1α residues 549-582 + elongin B + elongin C + PVHL
    • 1l3e - hFIH 1α C terminal + P300 Cys/His-rich domain – NMR
    • 1l8c - hFIH 1α C terminal + CREB-binding protein zinc finger
    • 4h6j - hFIH 1α PAS B domain (mutant) + aryl hydrocarbon nuclear translocator
    • 4b7e, 4b7k, 4jaa - hFIH1α + consensus ankyrin repeat peptide
  • FIH2α
    • 2a24, 3f1n, 3f1o, 3f1p, 3h7w - hFIH 2α PAS domain + hFIH 1β PAS domain
    • 3h82 - hFIH 2α PAS domain (mutant) + hFIH 1β PAS domain (mutant)
  • FIH1β

}}

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky

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