Farnesyltransferase
From Proteopedia
(Difference between revisions)
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| + | {{#tree:id=OrganizedByTopic|openlevels=0| | ||
| - | + | *FTase | |
| - | [[1ft1]] – rFTase – rat<br /> | + | **[[1ft1]] – rFTase – rat<br /> |
| - | [[3q73]] – CnFTase – ''Cryptococcus neoformans'' | + | **[[3q73]] – CnFTase – ''Cryptococcus neoformans'' |
| - | + | *FTase binary complex with FPP | |
| - | [[1ft2]], [[1fpp]] – rFTase + FPP<BR /> | + | **[[1ft2]], [[1fpp]] – rFTase + FPP<BR /> |
| - | [[1o1r]], [[1o1s]], [[3ksl]], [[3ksq]] - rFTase + FPP-analog<br /> | + | **[[1o1r]], [[1o1s]], [[3ksl]], [[3ksq]] - rFTase + FPP-analog<br /> |
| - | + | *FTase binary complex with peptide | |
| - | [[1kzp]], [[1o1t]] - rFTase + farnesylated peptide<br /> | + | **[[1kzp]], [[1o1t]] - rFTase + farnesylated peptide<br /> |
| - | [[2h6f]] - hFTase + farnesylated peptide<br /> | + | **[[2h6f]] - hFTase + farnesylated peptide<br /> |
| - | [[2h6g]], [[2h6h]], [[2h6i]] - hFTase α subunit + β subunit (mutant) + farnesylated peptide<br /> | + | **[[2h6g]], [[2h6h]], [[2h6i]] - hFTase α subunit + β subunit (mutant) + farnesylated peptide<br /> |
| - | [[3q79]] - CnFTase + farnesylated peptide | + | **[[3q79]] - CnFTase + farnesylated peptide |
| - | + | *FTase binary complex with inhibitor | |
| - | [[3eu5]] – rFTase + biotin-GPP<br /> | + | **[[3eu5]] – rFTase + biotin-GPP<br /> |
| - | [[3euv]] - rFTase α subunit + β subunit (mutant)+ biotin-GPP<br /> | + | **[[3euv]] - rFTase α subunit + β subunit (mutant)+ biotin-GPP<br /> |
| - | [[1n94]], [[1n95]], [[1n9a]], [[1o5m]], [[1ni1]], [[1x81]], [[2bed]], [[2r2l]] - rFTase + inhibitor<br /> | + | **[[1n94]], [[1n95]], [[1n9a]], [[1o5m]], [[1ni1]], [[1x81]], [[2bed]], [[2r2l]] - rFTase + inhibitor<br /> |
| - | [[1nl4]] - rFTase α subunit (mutant) + β subunit + inhibitor | + | **[[1nl4]] - rFTase α subunit (mutant) + β subunit + inhibitor |
| - | + | *FTase ternary complex with FPP and peptide | |
| - | [[1d8d]], [[1tn8]] - rFTase + Ras peptide + FPP-analog<br /> | + | **[[1d8d]], [[1tn8]] - rFTase + Ras peptide + FPP-analog<br /> |
| - | [[1kzo]] - rFTase + farnesylated Ras peptide + FPP<BR /> | + | **[[1kzo]] - rFTase + farnesylated Ras peptide + FPP<BR /> |
| - | [[1tn7]], [[3dpy]] - rFTase + peptide + FPP-analog<BR /> | + | **[[1tn7]], [[3dpy]] - rFTase + peptide + FPP-analog<BR /> |
| - | [[1jcr]], [[1jcs]] - rFTase + tetrapeptide inhibitor + FPP<BR /> | + | **[[1jcr]], [[1jcs]] - rFTase + tetrapeptide inhibitor + FPP<BR /> |
| - | [[1d8e]] - rFTase no Zn + Ras peptide + FPP-analog<br /> | + | **[[1d8e]] - rFTase no Zn + Ras peptide + FPP-analog<br /> |
| - | [[1tn6]] - hFTase + Rap2a peptide + FPP-analog<br /> | + | **[[1tn6]] - hFTase + Rap2a peptide + FPP-analog<br /> |
| - | [[3q75]], [[3q78]] - CnFTase + peptide + FPP-analog<br /> | + | **[[3q75]], [[3q78]] - CnFTase + peptide + FPP-analog<br /> |
| - | [[4l9p]] - AfFTase + peptide + FPP-analog – ''Apergillus fumigatus''<br /> | + | **[[4l9p]] - AfFTase + peptide + FPP-analog – ''Apergillus fumigatus''<br /> |
| - | + | *FTase ternary complex with FPP and inhibitor | |
| - | [[1sa5]], [[3e30]], [[3e32]], [[3e33]], [[3e34]], [[3e37]] - rFTase + inhibitor + FPP<BR /> | + | **[[1sa5]], [[3e30]], [[3e32]], [[3e33]], [[3e34]], [[3e37]] - rFTase + inhibitor + FPP<BR /> |
| - | [[2zir]], [[2zis]] - rFTase α subunit (mutant) + β subunit + inhibitor + FPP<BR /> | + | **[[2zir]], [[2zis]] - rFTase α subunit (mutant) + β subunit + inhibitor + FPP<BR /> |
| - | [[1jcq]] – hFTase α subunit (mutant) + β subunit + inhibitor + FPP– human<br /> | + | **[[1jcq]] – hFTase α subunit (mutant) + β subunit + inhibitor + FPP– human<br /> |
| - | [[1ld7]], [[1ld8]], [[1mzc]], [[1sa4]], [[1s63]], [[2f0y]] - hFTase + inhibitor + FPP<BR /> | + | **[[1ld7]], [[1ld8]], [[1mzc]], [[1sa4]], [[1s63]], [[2f0y]] - hFTase + inhibitor + FPP<BR /> |
| - | [[2iej]] - hFTase + inhibitor + FPP-analog<br /> | + | **[[2iej]] - hFTase + inhibitor + FPP-analog<br /> |
| - | [[3pz4]] - FTase + inhibitor + FPP – mouse<br /> | + | **[[3pz4]] - FTase + inhibitor + FPP – mouse<br /> |
| - | [[3q7a]], [[3q7f]] - CnFTase + inhibitor + FPP<BR /> | + | **[[3q7a]], [[3q7f]] - CnFTase + inhibitor + FPP<BR /> |
| - | [[3fsx]], [[3sfy]] - CnFTase + inhibitor + FPP-analog<br /> | + | **[[3fsx]], [[3sfy]] - CnFTase + inhibitor + FPP-analog<br /> |
| - | [[4lnb]], [[4lng]], [[4mbg]] - AfFTase (mutant) + inhibitor + FPP<br /> | + | **[[4lnb]], [[4lng]], [[4mbg]] - AfFTase (mutant) + inhibitor + FPP<br /> |
| - | + | *FTase ternary complex with GPP and protein | |
| + | **[[1n4p]], [[1n4r]], [[1n4s]] - rFTase α subunit + GTase β subunit + transforming protein + GPP<br /> | ||
| + | }} | ||
[[Category:Topic Page]] | [[Category:Topic Page]] | ||
Revision as of 13:49, 24 November 2014
Farnesyltransferase (FTase) is part of the prenyltransferase group. FTase modifies proteins by adding farnesyl diphosphate (FPP) – an isoprenoid lipid – to a cysteine near the C terminal. This addition forms a thioether linkage, makes the protein more hydrophobic and associates it with the membrane. Farnesylated proteins – like those of the Ras family - are involved in cellular signaling. Thus, FTase inhibitors are being tested as anti-cancer agents. FTase are composed of 2 subunits. The β subunit coordinates a Zn atom.
3D structures of farnesyltransferase
Updated on 24-November-2014
