Fibroblast growth factor

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{{#tree:id=OrganizedByTopic|openlevels=0|
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===FGF1===
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*FGF1
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[[1fmm]] – FGF1 – ''Notophthalmus viridescens'' - NMR <br />
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**[[1fmm]] – FGF1 – ''Notophthalmus viridescens'' - NMR <br />
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[[1afc]] – bFGF1 + HS – bovine<br />
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**[[1afc]] – bFGF1 + HS – bovine<br />
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[[1bar]] – bFGF1 <br />
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**[[1bar]] – bFGF1 <br />
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[[2j3p]] – rFGF1 - rat<br />
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**[[2j3p]] – rFGF1 - rat<br />
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[[3hal]] – FGF1 - rabbit <br />
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**[[3hal]] – FGF1 - rabbit <br />
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[[2afg]], [[1jqz]], [[1rg8]] – hFGF1 - human <br />
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**[[2afg]], [[1jqz]], [[1rg8]] – hFGF1 - human <br />
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[[1jt3]], [[1jt4]], [[1jt5]], [[1jt7]], [[1jtc]], [[1k5u]], [[1k5v]], [[1m16]], [[1jy0]], [[1nzk]], [[1p63]], [[1pzz]], [[1q03]], [[1q04]], [[1yto]], [[1z2v]], [[1z4s]], [[2aqz]], [[2hw9]], [[2hwa]], [[2hwm]], [[2hz9]], [[2ntd]], [[3b9u]], [[3ba4]], [[3ba5]], [[3ba7]], [[3bad]], [[3bag]], [[3bah]], [[3bao]], [[3baq]], [[3bau]], [[3bav]], [[3bb2]], [[2q9x]], [[3crg]], [[3crh]], [[3cri]], [[3cqa]], [[3fgm]], [[3fj8]], [[3fj9]], [[3fja]], [[3fjb]], [[3fjc]], [[3fjd]], [[3fje]], [[3fjf]], [[3fjh]], [[3fji]], [[3fjj]], [[3fjk]], [[3hom]], [[3o3q]] – hFGF1 (mutant) <br />
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**[[1jt3]], [[1jt4]], [[1jt5]], [[1jt7]], [[1jtc]], [[1k5u]], [[1k5v]], [[1m16]], [[1jy0]], [[1nzk]], [[1p63]], [[1pzz]], [[1q03]], [[1q04]], [[1yto]], [[1z2v]], [[1z4s]], [[2aqz]], [[2hw9]], [[2hwa]], [[2hwm]], [[2hz9]], [[2ntd]], [[3b9u]], [[3ba4]], [[3ba5]], [[3ba7]], [[3bad]], [[3bag]], [[3bah]], [[3bao]], [[3baq]], [[3bau]], [[3bav]], [[3bb2]], [[2q9x]], [[3crg]], [[3crh]], [[3cri]], [[3cqa]], [[3fgm]], [[3fj8]], [[3fj9]], [[3fja]], [[3fjb]], [[3fjc]], [[3fjd]], [[3fje]], [[3fjf]], [[3fjh]], [[3fji]], [[3fjj]], [[3fjk]], [[3hom]], [[3o3q]] – hFGF1 (mutant) <br />
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[[1dzd]], [[2rq9]] – hFGF1 - NMR <br />
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**[[1dzd]], [[2rq9]] – hFGF1 - NMR <br />
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[[1dzc]] – hFGF1 (mutant) - NMR <br />
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**[[1dzc]] – hFGF1 (mutant) - NMR <br />
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''FGF1 complex with small molecule''
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*''FGF1 complex with small molecule''
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[[1axm]], [[2axm]] – hFGF1 + HS <br />
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**[[1axm]], [[2axm]] – hFGF1 + HS <br />
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[[3ud7]], [[3ud8]], [[3ud9]], [[3uda]] – hFGF1 + disaccharide <br />
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**[[3ud7]], [[3ud8]], [[3ud9]], [[3uda]] – hFGF1 + disaccharide <br />
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[[2uus]] – rFGF1 + HS <br />
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**[[2uus]] – rFGF1 + HS <br />
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[[2erm]] – hFGF1 + HS - NMR<br />
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**[[2erm]] – hFGF1 + HS - NMR<br />
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[[1rml]] – hFGF1 + naphthalene trisulphonate - NMR <br />
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**[[1rml]] – hFGF1 + naphthalene trisulphonate - NMR <br />
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[[1hkn]] – hFGF1 + naphthalene trisulphonate <br />
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**[[1hkn]] – hFGF1 + naphthalene trisulphonate <br />
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[[2k8r]] – hFGF1 + anti-angiogenic drug - NMR<br />
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**[[2k8r]] – hFGF1 + anti-angiogenic drug - NMR<br />
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[[3k1x]] – hFGF1 + vasoprotectant drug <br />
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**[[3k1x]] – hFGF1 + vasoprotectant drug <br />
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[[3jut]] – hFGF1 + inhibitor <br />
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**[[3jut]] – hFGF1 + inhibitor <br />
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[[2ki4]], [[2ki6]] – hFGF1 + S100-A13<br />
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**[[2ki4]], [[2ki6]] – hFGF1 + S100-A13<br />
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''FGF1 complex with FGF receptor''
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*''FGF1 complex with FGF receptor''
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[[1e0o]] – hFGF1 (mutant) + hFGFR2 (mutant) + HS<br />
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**[[1e0o]] – hFGF1 (mutant) + hFGFR2 (mutant) + HS<br />
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[[3oj2]], [[3ojm]], [[1djs]] – hFGF1 + hFGFR2 (mutant) <br />
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**[[3oj2]], [[3ojm]], [[1djs]] – hFGF1 + hFGFR2 (mutant) <br />
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[[1evt]] – hFGF1 + hFGFR1 <br />
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**[[1evt]] – hFGF1 + hFGFR1 <br />
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[[3ojv]] – hFGF1 + hFGFR1 (mutant) <br />
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**[[3ojv]] – hFGF1 + hFGFR1 (mutant) <br />
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[[1ry7]] – hFGF1 + hFGFR3<br />
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**[[1ry7]] – hFGF1 + hFGFR3<br />
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[[3cu1]] – hFGF1 + hFGFR2<br />
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**[[3cu1]] – hFGF1 + hFGFR2<br />
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===FGF2===
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*FGF2
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[[2fgf]] – hFGF2 precursor <br />
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**[[2fgf]] – hFGF2 precursor <br />
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[[1fga]], [[4fgf]], [[1bas]], [[1bfg]], [[2bfh]], [[1bff]] – hFGF2 <br />
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**[[1fga]], [[4fgf]], [[1bas]], [[1bfg]], [[2bfh]], [[1bff]] – hFGF2 <br />
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[[1wvz]], [[2k43]], [[2k4a]] – hFGF2 - NMR <br />
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**[[1wvz]], [[2k43]], [[2k4a]] – hFGF2 - NMR <br />
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[[1bla]], [[1bld]] – hFGF2 (mutant) - NMR <br />
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**[[1bla]], [[1bld]] – hFGF2 (mutant) - NMR <br />
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[[1bfb]], [[1bfc]] – hFGF2 + heparin <br />
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**[[1bfb]], [[1bfc]] – hFGF2 + heparin <br />
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[[1cvs]] – hFGF2 (mutant) + hFGFR1 (mutant) <br />
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**[[1cvs]] – hFGF2 (mutant) + hFGFR1 (mutant) <br />
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[[1fq9]] – hFGF2 (mutant) + hFGFR1 (mutant) + HS<br />
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**[[1fq9]] – hFGF2 (mutant) + hFGFR1 (mutant) + HS<br />
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[[1ev2]] - hFGF2 (mutant) + hFGFR2 <br />
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**[[1ev2]] - hFGF2 (mutant) + hFGFR2 <br />
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[[2m49]] - hFGF2 (mutant) + S100-B <br />
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**[[2m49]] - hFGF2 (mutant) + S100-B <br />
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===FGF4===
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*FGF4
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[[1ijt]] – hFGF4 b-trefoil domain <br />
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**[[1ijt]] – hFGF4 b-trefoil domain <br />
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===FGF7===
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*FGF7
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[[1qqk]] – rFGF7 <br />
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**[[1qqk]] – rFGF7 <br />
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[[1qql]] – rFGF7/hFGF1 <br />
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**[[1qql]] – rFGF7/hFGF1 <br />
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===FGF8===
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*FGF8
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[[2fdb]] – hFGF8b + hFGFR2 <br />
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**[[2fdb]] – hFGF8b + hFGFR2 <br />
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===FGF9===
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*FGF9
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[[1g82]], [[1ihk]] – hFGF9 <br />
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**[[1g82]], [[1ihk]] – hFGF9 <br />
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===FGF10===
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*FGF10
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[[1nun]] – hFGF10 + hFGFR2 <br />
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**[[1nun]] – hFGF10 + hFGFR2 <br />
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===FGF12===
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*FGF12
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[[1q1u]] – hFGF12 (mutant) <br />
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**[[1q1u]] – hFGF12 (mutant) <br />
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===FGF13===
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*FGF13
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[[3hbw]] – hFGF13 <br />
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**[[3hbw]] – hFGF13 <br />
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[[4dck]] – hFGF13 + calmodulin + sodium channel subunit α <br />
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**[[4dck]] – hFGF13 + calmodulin + sodium channel subunit α <br />
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===FGF19===
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*FGF19
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[[1pwa]], [[2p23]] – hFGF19 <br />
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**[[1pwa]], [[2p23]] – hFGF19 <br />
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===FGF20===
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*FGF20
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[[3f1r]] – hFGF20 <br />
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**[[3f1r]] – hFGF20 <br />
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===FGF23===
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*FGF23
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[[2p39]] – hFGF23 <br />
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**[[2p39]] – hFGF23 <br />
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}}
[[Category:Topic Page]]
[[Category:Topic Page]]

Revision as of 07:43, 25 November 2014

Template:STRUCTURE 2uus


Fibroblast growth factors (FGF) are involved in angiogenesis, wound-healing and embryonic development. FGF is heparin-binding protein. FGF require heparan sulfate (HS) to activate the four FGF cell-surface receptors (FGFR). In vertebrates there are 23 members in the FGF family. FGF signaling is important in the pathogenesis of a variety of tumor types.

  • FGF1 is called acidic FGF.
  • FGF2 is called basic FGF.
  • FGF7 is called keratinocyte growth factor which is present in the eiptheliazation-phase of wound healing when keratinocytes are covering the wound.

3D structures of fibroblast growth factor

Updated on 25-November-2014

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky

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