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1lsl

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[[Image:1lsl.jpg|left|200px]]<br /><applet load="1lsl" size="350" color="white" frame="true" align="right" spinBox="true"
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[[Image:1lsl.jpg|left|200px]]
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caption="1lsl, resolution 1.90&Aring;" />
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'''Crystal Structure of the Thrombospondin-1 Type 1 Repeats'''<br />
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{{Structure
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|PDB= 1lsl |SIZE=350|CAPTION= <scene name='initialview01'>1lsl</scene>, resolution 1.90&Aring;
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|SITE=
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|LIGAND= <scene name='pdbligand=FUL:BETA-L-FUCOSE'>FUL</scene> and <scene name='pdbligand=FUC:ALPHA-L-FUCOSE'>FUC</scene>
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|ACTIVITY=
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|GENE= THBS1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
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}}
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'''Crystal Structure of the Thrombospondin-1 Type 1 Repeats'''
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==Overview==
==Overview==
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==About this Structure==
==About this Structure==
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1LSL is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with <scene name='pdbligand=FUL:'>FUL</scene> and <scene name='pdbligand=FUC:'>FUC</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1LSL OCA].
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1LSL is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1LSL OCA].
==Reference==
==Reference==
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Crystal structure of the TSP-1 type 1 repeats: a novel layered fold and its biological implication., Tan K, Duquette M, Liu JH, Dong Y, Zhang R, Joachimiak A, Lawler J, Wang JH, J Cell Biol. 2002 Oct 28;159(2):373-82. Epub 2002 Oct 21. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=12391027 12391027]
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Crystal structure of the TSP-1 type 1 repeats: a novel layered fold and its biological implication., Tan K, Duquette M, Liu JH, Dong Y, Zhang R, Joachimiak A, Lawler J, Wang JH, J Cell Biol. 2002 Oct 28;159(2):373-82. Epub 2002 Oct 21. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/12391027 12391027]
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Single protein]]
[[Category: Single protein]]
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[[Category: tsr]]
[[Category: tsr]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 13:48:02 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 12:34:43 2008''

Revision as of 10:34, 20 March 2008

Image:1lsl.jpg


PDB ID 1lsl

Drag the structure with the mouse to rotate
, resolution 1.90Å
Ligands: and
Gene: THBS1 (Homo sapiens)
Coordinates: save as pdb, mmCIF, xml



Crystal Structure of the Thrombospondin-1 Type 1 Repeats


Contents

Overview

Thrombospondin-1 (TSP-1) contains three type 1 repeats (TSRs), which mediate cell attachment, glycosaminoglycan binding, inhibition of angiogenesis, activation of TGFbeta, and inhibition of matrix metalloproteinases. The crystal structure of the TSRs reported in this article reveals a novel, antiparallel, three-stranded fold that consists of alternating stacked layers of tryptophan and arginine residues from respective strands, capped by disulfide bonds on each end. The front face of the TSR contains a right-handed spiral, positively charged groove that might be the "recognition" face, mediating interactions with various ligands. This is the first high-resolution crystal structure of a TSR domain that provides a prototypic architecture for structural and functional exploration of the diverse members of the TSR superfamily.

Disease

Known disease associated with this structure: Sudden infant death with dysgenesis of the testes syndrome OMIM:[604714]

About this Structure

1LSL is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Crystal structure of the TSP-1 type 1 repeats: a novel layered fold and its biological implication., Tan K, Duquette M, Liu JH, Dong Y, Zhang R, Joachimiak A, Lawler J, Wang JH, J Cell Biol. 2002 Oct 28;159(2):373-82. Epub 2002 Oct 21. PMID:12391027

Page seeded by OCA on Thu Mar 20 12:34:43 2008

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