Glutamate dehydrogenase

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{{#tree:id=OrganizedByTopic|openlevels=0|
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[[1gtm]] – GLDH – ''Pyrococcus furiosus''<br />
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*Glutamate dehydrogenase
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[[1hrd]] – CsGLDH – ''Clostridium symbiosum''<br />
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[[1aup]], [[1k89]] – CsGLDH (mutant)<br />
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[[1bvu]] – GLDH – ''Thermococcus litoralis''<br />
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[[1euz]] - GLDH – ''Thermococcus profundus''<br />
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[[1b26]] – TmGLDH – ''Thermotoga maritima''<br />
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[[1b3b]], [[2tmg]] - TmGLDH (mutant)<br />
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[[1l1f]] – hGLDH1 – human<br />
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[[1nr1]] – hGLDH1 (mutant)<br />
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[[1nr7]] – bGLDH – bovine<br />
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[[3mvo]], [[3mvq]] – bGLDH1<br />
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[[2bma]] – PfGLDH – ''Plasmodium falciparum''<br />
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[[3r3j]] - PfGLDH (mutant)<br />
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[[3k8z]], [[3k92]] – GLDH (mutant) – ''Bacillus subtilis''<br />
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[[2yfq]] - bGLDH – ''Peptoniphilus asaccharolyticus''<br />
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[[3sbo]], [[2yfg]], [[4bht]], [[4fcc]] - EcGLDH – ''Escherichia coli''<br />
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[[2yfh]] – EcGLDH/CsGLDH
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===Glutamate dehydrogenase complex===
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**[[1gtm]] – GLDH – ''Pyrococcus furiosus''<br />
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**[[1hrd]] – CsGLDH – ''Clostridium symbiosum''<br />
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**[[1aup]], [[1k89]] – CsGLDH (mutant)<br />
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**[[1bvu]] – GLDH – ''Thermococcus litoralis''<br />
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**[[1euz]] - GLDH – ''Thermococcus profundus''<br />
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**[[1b26]] – TmGLDH – ''Thermotoga maritima''<br />
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**[[1b3b]], [[2tmg]] - TmGLDH (mutant)<br />
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**[[1l1f]] – hGLDH1 – human<br />
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**[[1nr1]] – hGLDH1 (mutant)<br />
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**[[1nr7]] – bGLDH – bovine<br />
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**[[3mvo]], [[3mvq]] – bGLDH1<br />
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**[[2bma]] – PfGLDH – ''Plasmodium falciparum''<br />
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**[[3r3j]] - PfGLDH (mutant)<br />
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**[[3k8z]], [[3k92]] – GLDH (mutant) – ''Bacillus subtilis''<br />
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**[[2yfq]] - bGLDH – ''Peptoniphilus asaccharolyticus''<br />
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**[[3sbo]], [[2yfg]], [[4bht]], [[4fcc]] - EcGLDH – ''Escherichia coli''<br />
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**[[2yfh]] – EcGLDH/CsGLDH
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[[1hwy]] – bGLDH + NAD + 2-oxoglutarate <br />
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*Glutamate dehydrogenase complex
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[[1hwz]] – bGLDH + NADP + GTP + glutamate <br />
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[[3mw9]] - bGLDH + NAD + GTP + glutamate <br />
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[[3ete]], [[3etg]] - bGLDH + NADP + GTP + inhibitor + glutamate <br />
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[[1nqt]] - bGLDH + ADP<br />
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[[3qmu]] - bGLDH + NADP + epicatechin-e-gallate<br />
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[[1bgv]] – CsGLDH + glutamate <br />
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[[1v9l]] - GLDH + NAD – ''Pyrobaculum islandicum''<br />
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[[3aoe]] - TtGLDH + leucine – ''Thermus thermophilus''<br />
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[[3aog]] - TtGLDH + NH4 + glutamate <br />
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[[4fhn]] – EcGLDH + Nup37 + Nup120<br />
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**[[1hwy]] – bGLDH + NAD + 2-oxoglutarate <br />
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**[[1hwz]] – bGLDH + NADP + GTP + glutamate <br />
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**[[3mw9]] - bGLDH + NAD + GTP + glutamate <br />
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**[[3ete]], [[3etg]] - bGLDH + NADP + GTP + inhibitor + glutamate <br />
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**[[1nqt]] - bGLDH + ADP<br />
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**[[3qmu]] - bGLDH + NADP + epicatechin-e-gallate<br />
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**[[1bgv]] – CsGLDH + glutamate <br />
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**[[1v9l]] - GLDH + NAD – ''Pyrobaculum islandicum''<br />
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**[[3aoe]] - TtGLDH + leucine – ''Thermus thermophilus''<br />
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**[[3aog]] - TtGLDH + NH4 + glutamate <br />
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**[[4fhn]] – EcGLDH + Nup37 + Nup120<br />
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}}
[[Category:Topic Page]]
[[Category:Topic Page]]

Revision as of 07:47, 26 November 2014

Template:STRUCTURE 1gtm Glutamate dehydrogenase (GLDH) catalyzes the reversible conversion of glutamate to α-ketoglutarate and ammonium. The ammonia is removed via the urea cycle. Elevated GLDH values in blood serum indicate liver malfunction. NAD or NADP is a cofactor in GLDH activity. NAD is a cofactor in the forward reaction while NADP is a cofactor in the reverse. GLDH is regulated by the cell’s energy state. ATP and GTP inhibit the enzyme while ADP, GDP and leucine positively enhance it. Glutamate dehydrogenase 1 (GLDH1) catalyzes the deamination of glutamate to 2-oxoglutarate and ammonium. GLDH1 is regulated in the same manner as GLDH.

3D structures of glutamate dehydrogenase

Updated on 26-November-2014

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky, Joel L. Sussman

Retrieved from "http://52.214.119.220/wiki/index.php/Glutamate_dehydrogenase"
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