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4wo4
From Proteopedia
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| - | ''' | + | ==The molecular bases of Delta/Alpha beta T cell-mediated antigen recognition.== |
| - | + | <StructureSection load='4wo4' size='340' side='right' caption='[[4wo4]], [[Resolution|resolution]] 2.50Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[4wo4]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4WO4 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4WO4 FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=JLS:(15Z)-N-[(2S,3S,4R)-1-(ALPHA-D-GALACTOPYRANOSYLOXY)-3,4-DIHYDROXYOCTADECAN-2-YL]TETRACOS-15-ENAMIDE'>JLS</scene>, <scene name='pdbligand=FUC:ALPHA-L-FUCOSE'>FUC</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr> | |
| - | + | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4wnq|4wnq]]</td></tr> | |
| - | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4wo4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4wo4 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4wo4 RCSB], [http://www.ebi.ac.uk/pdbsum/4wo4 PDBsum]</span></td></tr> | |
| + | </table> | ||
| + | == Disease == | ||
| + | [[http://www.uniprot.org/uniprot/B2MG_HUMAN B2MG_HUMAN]] Defects in B2M are the cause of hypercatabolic hypoproteinemia (HYCATHYP) [MIM:[http://omim.org/entry/241600 241600]]. Affected individuals show marked reduction in serum concentrations of immunoglobulin and albumin, probably due to rapid degradation.<ref>PMID:16549777</ref> Note=Beta-2-microglobulin may adopt the fibrillar configuration of amyloid in certain pathologic states. The capacity to assemble into amyloid fibrils is concentration dependent. Persistently high beta(2)-microglobulin serum levels lead to amyloidosis in patients on long-term hemodialysis.<ref>PMID:3532124</ref> <ref>PMID:1336137</ref> <ref>PMID:7554280</ref> <ref>PMID:4586824</ref> <ref>PMID:8084451</ref> <ref>PMID:12119416</ref> <ref>PMID:12796775</ref> <ref>PMID:16901902</ref> <ref>PMID:16491088</ref> <ref>PMID:17646174</ref> <ref>PMID:18835253</ref> <ref>PMID:18395224</ref> <ref>PMID:19284997</ref> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/CD1D_HUMAN CD1D_HUMAN]] Antigen-presenting protein that binds self and non-self glycolipids and presents them to T-cell receptors on natural killer T-cells.<ref>PMID:17475845</ref> [[http://www.uniprot.org/uniprot/B2MG_HUMAN B2MG_HUMAN]] Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system. | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Besra, G]] | ||
| + | [[Category: Boer, R de]] | ||
| + | [[Category: Chabrol, E]] | ||
| + | [[Category: Eckle, S B.G]] | ||
| + | [[Category: Godfrey, D I]] | ||
| + | [[Category: Gras, S]] | ||
| + | [[Category: Heemskerk, M H.M]] | ||
| + | [[Category: Howell, A R]] | ||
| + | [[Category: Lim, R T]] | ||
| + | [[Category: McCluskey, J]] | ||
| + | [[Category: McPherson, K]] | ||
| + | [[Category: Moretta, L]] | ||
| + | [[Category: Nours, J Le]] | ||
| + | [[Category: Pellicci, D G]] | ||
| + | [[Category: Ross, F]] | ||
| + | [[Category: Rossjohn, J]] | ||
| + | [[Category: Uldrich, A P]] | ||
| + | [[Category: Immune system]] | ||
| + | [[Category: Immunity]] | ||
Revision as of 08:19, 26 November 2014
The molecular bases of Delta/Alpha beta T cell-mediated antigen recognition.
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Categories: Besra, G | Boer, R de | Chabrol, E | Eckle, S B.G | Godfrey, D I | Gras, S | Heemskerk, M H.M | Howell, A R | Lim, R T | McCluskey, J | McPherson, K | Moretta, L | Nours, J Le | Pellicci, D G | Ross, F | Rossjohn, J | Uldrich, A P | Immune system | Immunity
