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3f5c
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| - | [[ | + | ==Structure of Dax-1:LRH-1 complex== |
| + | <StructureSection load='3f5c' size='340' side='right' caption='[[3f5c]], [[Resolution|resolution]] 3.00Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[3f5c]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3F5C OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3F5C FirstGlance]. <br> | ||
| + | </td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">Nr5a2, Lrh1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 Mus musculus]), Nr0b1, Ahch, Dax1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 Mus musculus])</td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3f5c FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3f5c OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3f5c RCSB], [http://www.ebi.ac.uk/pdbsum/3f5c PDBsum]</span></td></tr> | ||
| + | </table> | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | The Dax-1 protein is an enigmatic nuclear receptor that lacks an expected DNA binding domain, yet functions as a potent corepressor of nuclear receptors. Here we report the structure of Dax-1 bound to one of its targets, liver receptor homolog 1 (LRH-1). Unexpectedly, Dax-1 binds to LRH-1 using a new module, a repressor helix built from a family conserved sequence motif, PCFXXLP. Mutations in this repressor helix that are linked with human endocrine disorders dissociate the complex and attenuate Dax-1 function. The structure of the Dax-1:LRH-1 complex provides the molecular mechanism for the function of Dax-1 as a potent transcriptional repressor. | ||
| - | + | The structure of corepressor Dax-1 bound to its target nuclear receptor LRH-1.,Sablin EP, Woods A, Krylova IN, Hwang P, Ingraham HA, Fletterick RJ Proc Natl Acad Sci U S A. 2008 Nov 25;105(47):18390-5. Epub 2008 Nov 17. PMID:19015525<ref>PMID:19015525</ref> | |
| - | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |
| - | + | </div> | |
| - | + | == References == | |
| - | + | <references/> | |
| - | == | + | __TOC__ |
| - | + | </StructureSection> | |
[[Category: Mus musculus]] | [[Category: Mus musculus]] | ||
| - | [[Category: Fletterick, R J | + | [[Category: Fletterick, R J]] |
| - | [[Category: Sablin, E P | + | [[Category: Sablin, E P]] |
[[Category: Dna-binding]] | [[Category: Dna-binding]] | ||
[[Category: Lipid-binding]] | [[Category: Lipid-binding]] | ||
Revision as of 08:49, 26 November 2014
Structure of Dax-1:LRH-1 complex
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