Growth factor receptor-bound protein

Growth factor receptor-bound proteins (GRB) are adaptor proteins. GRBs contain SH2, Ras-associated (RA) and pleckstrin homology (PH) domains.

• GRB2 links the epidermal growth factor receptor tyrosine kinase to the activation of Ras and its downstream kinases. GRB2 contains an SH2 domain which binds tyrosine phosphorylated sequences and 2 SH3 domains which direct complex formation of proline-rich sequences. GRB2 is involved in signal transduction.
  
• GRB7 interacts with EGFR and ephrin receptors and plays a role in itegrin signalling pathway.
  
• GRB10 interacts with insulin receptor and insulin-like growth factor receptors. For additional details on GRB10 see Grb10 SH2 Domain.