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Hirudin
From Proteopedia
(Difference between revisions)
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| + | {{#tree:id=OrganizedByTopic|openlevels=0| | ||
| - | + | * Hirudin | |
| - | [[1hic]], [[2hir]], [[4hir]], [[5hir]], [[6hir]] – Hir – NMR<br /> | + | **[[1hic]], [[2hir]], [[4hir]], [[5hir]], [[6hir]] – Hir – NMR<br /> |
| - | [[2joo]] - Hir – NMR<br /> | + | **[[2joo]] - Hir – NMR<br /> |
| - | + | * Hirudin + Thrombin light and heavy chains | |
| - | [[1hrt]], [[3htc]], [[4htc]] - Hir +hThr L&H chains<br /> | + | **[[1hrt]], [[3htc]], [[4htc]] - Hir +hThr L&H chains<br /> |
| - | [[3da9]], [[3utu]] - Hir peptide+hThr L&H chains<br /> | + | **[[3da9]], [[3utu]] - Hir peptide+hThr L&H chains<br /> |
| - | [[3qtv]], [[3qwc]], [[3qx5]] - Hir peptide + hThr L&H chains + pyridine derivative<br /> | + | **[[3qtv]], [[3qwc]], [[3qx5]] - Hir peptide + hThr L&H chains + pyridine derivative<br /> |
| - | [[3rlw]], [[3rly]], [[3rm0]], [[3rm2]], [[3rml]], [[3rmm]], [[3rmn]], [[3rmo]] - Hir peptide + hThr L&H chains + inhibitor<br /> | + | **[[3rlw]], [[3rly]], [[3rm0]], [[3rm2]], [[3rml]], [[3rmm]], [[3rmn]], [[3rmo]] - Hir peptide + hThr L&H chains + inhibitor<br /> |
| - | [[3qto]] - Hir +hThr L&H chains + pyridine derivative | + | **[[3qto]] - Hir +hThr L&H chains + pyridine derivative |
| - | + | * Hirugen + Thrombin light and heavy chains | |
| - | [[2zhe]], [[2zhf]], [[2zhw]], [[2zg0]], [[2zfq]], [[2zfr]], [[1c5l]], [[1hxf]], [[1hah]], [[1hai]], [[1abi]], [[1abj]], [[1hgt]], [[2uuf]], [[1aix]], [[1ay6]] - Hirg+ hThr L&H chains<br /> | + | **[[2zhe]], [[2zhf]], [[2zhw]], [[2zg0]], [[2zfq]], [[2zfr]], [[1c5l]], [[1hxf]], [[1hah]], [[1hai]], [[1abi]], [[1abj]], [[1hgt]], [[2uuf]], [[1aix]], [[1ay6]] - Hirg+ hThr L&H chains<br /> |
| - | + | * Hirugen + prothrombin | |
| - | [[2cn0]], [[3c1k]] – Hirg+ hProThr<br /> | + | **[[2cn0]], [[3c1k]] – Hirg+ hProThr<br /> |
| - | [[1t4u]], [[1t4v]], [[1o5g]], [[1g30]], [[1g32]], [[1twx]], [[3tu7]] - Hirg+hProThr+inhibitor <br /> | + | **[[1t4u]], [[1t4v]], [[1o5g]], [[1g30]], [[1g32]], [[1twx]], [[3tu7]] - Hirg+hProThr+inhibitor <br /> |
| - | + | * Hirugen + Prethrombin | |
| - | [[1hag]] – Hirg+hPreThr<br /> | + | **[[1hag]] – Hirg+hPreThr<br /> |
| - | + | * Hirugen + thrombin heavy chain | |
| - | [[1nm6]] – Hirg+ hThr H chain<br /> | + | **[[1nm6]] – Hirg+ hThr H chain<br /> |
| - | [[1nt1]] - Hirg+ hThr H chain+inhibitor<br /> | + | **[[1nt1]] - Hirg+ hThr H chain+inhibitor<br /> |
| - | + | * Hirugen + thrombin light and heavy chains+inhibitor | |
| - | [[1fph]], [[7kme]] - Hirg +hThr L&H chains+polypeptide<br /> | + | **[[1fph]], [[7kme]] - Hirg +hThr L&H chains+polypeptide<br /> |
| - | [[1hxe]] - Hirg +hThr L&H chains+Rb<br /> | + | **[[1hxe]] - Hirg +hThr L&H chains+Rb<br /> |
| - | [[1ypk]], [[1riw]], [[1mu6]], [[1mu8]], [[1mue]], [[1no9]], [[1oyt]], [[1o2g]], [[1ny2]], [[1gj4]], [[1gj5]], [[1kts]], [[1ktt]], [[1ghv]], [[1ghw]], [[1ghx]], [[1ghy]], [[1h8i]], [[1h8d]], [[1c5n]], [[1c5o]], [[1c1u]], [[1c1v]], [[1c1w]], [[1qj1]], [[1qj6]], [[1qj7]], [[1qbv]], [[1bcu]], [[1a2c]], [[1a61]], [[1a46]], [[1a5g]], [[1b5g]], [[1ad8]], [[1ai8]], [[1tom]], [[1bmm]], [[1bmn]], [[1lhc]], [[1lhd]], [[1lhe]], [[1lhf]], [[1lhg]], [[1uma]], [[1aht]], [[1fpc]], [[3hat]], [[1tmu]], [[1dwb]], [[1dwc]], [[1dwd]], [[1dwe]], [[1tmb]], [[3f68]], [[3eq0]], [[3dt0]], [[3dux]], [[3dhk]], [[2znk]], [[2zo3]], [[3d49]], [[2zhq]], [[2zi2]], [[2ziq]], [[2zff]], [[2zfp]], [[2zgb]], [[2zgx]], [[2zf0]], [[2zc9]], [[2zda]], [[2zdv]], [[3egk]], [[2pw8]], [[3c27]], [[2r2m]], [[2cf8]], [[2cf9]], [[2bdy]], [[2v3h]], [[2v3o]], [[1w7g]], [[1ype]], [[1ypg]], [[1ypj]], [[3biu]], [[3biv]], [[1doj]], [[1ypl]], [[1ypm]], [[1vzq]], [[1way]], [[1wbg]], [[1k21]], [[1k22]], [[1afe]], [[1ae8]] ,[[1a3b]], [[1a3e]], [[1vr1]], [[2bvr]], [[2bvs]], [[2bvx]], [[2bxt]], [[2bxu]], [[2gde]], [[2pks]], [[3ldx]], [[3p17]], [[1d9i]], [[1xm1]], [[4n3l]], [[4nze]] – Hirg+ hThr L&H chains+inhibitor<br /> | + | **[[1ypk]], [[1riw]], [[1mu6]], [[1mu8]], [[1mue]], [[1no9]], [[1oyt]], [[1o2g]], [[1ny2]], [[1gj4]], [[1gj5]], [[1kts]], [[1ktt]], [[1ghv]], [[1ghw]], [[1ghx]], [[1ghy]], [[1h8i]], [[1h8d]], [[1c5n]], [[1c5o]], [[1c1u]], [[1c1v]], [[1c1w]], [[1qj1]], [[1qj6]], [[1qj7]], [[1qbv]], [[1bcu]], [[1a2c]], [[1a61]], [[1a46]], [[1a5g]], [[1b5g]], [[1ad8]], [[1ai8]], [[1tom]], [[1bmm]], [[1bmn]], [[1lhc]], [[1lhd]], [[1lhe]], [[1lhf]], [[1lhg]], [[1uma]], [[1aht]], [[1fpc]], [[3hat]], [[1tmu]], [[1dwb]], [[1dwc]], [[1dwd]], [[1dwe]], [[1tmb]], [[3f68]], [[3eq0]], [[3dt0]], [[3dux]], [[3dhk]], [[2znk]], [[2zo3]], [[3d49]], [[2zhq]], [[2zi2]], [[2ziq]], [[2zff]], [[2zfp]], [[2zgb]], [[2zgx]], [[2zf0]], [[2zc9]], [[2zda]], [[2zdv]], [[3egk]], [[2pw8]], [[3c27]], [[2r2m]], [[2cf8]], [[2cf9]], [[2bdy]], [[2v3h]], [[2v3o]], [[1w7g]], [[1ype]], [[1ypg]], [[1ypj]], [[3biu]], [[3biv]], [[1doj]], [[1ypl]], [[1ypm]], [[1vzq]], [[1way]], [[1wbg]], [[1k21]], [[1k22]], [[1afe]], [[1ae8]] ,[[1a3b]], [[1a3e]], [[1vr1]], [[2bvr]], [[2bvs]], [[2bvx]], [[2bxt]], [[2bxu]], [[2gde]], [[2pks]], [[3ldx]], [[3p17]], [[1d9i]], [[1xm1]], [[4n3l]], [[4nze]] – Hirg+ hThr L&H chains+inhibitor<br /> |
| - | [[1sb1]] – Hirg+ hproThr L&H chains+inhibitor<br /> | + | **[[1sb1]] – Hirg+ hproThr L&H chains+inhibitor<br /> |
| - | + | * Hirugen+Thrombin light and heavy chains+ protein | |
| - | [[1vit]] - Hirg+hThr L&H chains+ε-hThr<br /> | + | **[[1vit]] - Hirg+hThr L&H chains+ε-hThr<br /> |
| - | [[1nrs]] - Hirg+hThr L&H chains + receptor based peptide<br /> | + | **[[1nrs]] - Hirg+hThr L&H chains + receptor based peptide<br /> |
| - | + | * Hirugen+ α-Thrombin +inhibitor | |
| - | + | ||
| - | + | ||
| + | **[[1zrb]], [[1z71]], [[1sl3]], [[1ta2]], [[1ta6]], [[1zgi]], [[1zgv]], [[2uuk]], [[2uuj]], [[2jh0]], [[2jh5]], [[2jh6]], [[2c8w]], [[2c8x]], [[2c8y]], [[2c8z]], [[2c90]], [[2c93]], [[8kme]] – Hirg+α-hThr+inhibitor<br /> | ||
| + | }} | ||
[[Category:Topic Page]] | [[Category:Topic Page]] | ||
Revision as of 09:39, 27 November 2014
Hirudin (Hir) is a powerful anticoagulant which is found in the leech salivary glands. It is an inhibitor of thrombin (Thr) which converts fibrinogen to fibrin upon blood clotting. Thrombin is produced upon enzymatic cleavage of prothrombin (ProThr). Hirugen (Hirg) is a dodecapeptide of the C-terminal of Hir (sequence NDGDFEEIPEEYL). The image at the right correspond to one representative Hirudin, i.e. the NMR Structure of Hirudin (1hic). For additional details see Sean Swale/Human Thrombin Inhibitor.
3D Structures of Hirudin
Updated on 27-November-2014
