Histone deacetylase

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Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
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{{#tree:id=OrganizedByTopic|openlevels=0|
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===HDAC class I===
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*'''HDAC class I'''
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''HDAC1''
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*HDAC1
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[[4bkx]] – hHDAC1 + MTA1 – human<br />
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**[[4bkx]] – hHDAC1 + MTA1 – human<br />
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[[3hgq]], [[3hgt]] – hHDAC1 subunit 3<br />
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**[[3hgq]], [[3hgt]] – hHDAC1 subunit 3<br />
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''HDAC2''
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*HDAC2
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[[3max]] – hHDAC2 + amide derivative <br />
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**[[3max]] – hHDAC2 + amide derivative <br />
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[[4lxz]] – hHDAC2 core domain + SAHA<br />
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**[[4lxz]] – hHDAC2 core domain + SAHA<br />
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[[4ly1]] – hHDAC2 core domain + inhibitor<br />
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**[[4ly1]] – hHDAC2 core domain + inhibitor<br />
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''HDAC3''
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*HDAC3
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[[4a69]] – hHDAC3 + nuclear receptor corepressor 2 + inositol tetraphosphate
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**[[4a69]] – hHDAC3 + nuclear receptor corepressor 2 + inositol tetraphosphate
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''HDAC8''
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*HDAC8
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[[3ew8]], [[3ezp]], [[3ezt]], [[3f06]] – hHDAC8 (mutant)<br />
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**[[3ew8]], [[3ezp]], [[3ezt]], [[3f06]] – hHDAC8 (mutant)<br />
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[[3sff]], [[3sfh]] – hHDAC8 + inhibitor<br />
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**[[3sff]], [[3sfh]] – hHDAC8 + inhibitor<br />
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[[1t64]], [[3f0r]] – hHDAC8 + trichostatin A <br />
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**[[1t64]], [[3f0r]] – hHDAC8 + trichostatin A <br />
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[[1t67]], [[1w22]], [[1vkg]], [[3f07]] - hHDAC8 + amide derivative<br />
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**[[1t67]], [[1w22]], [[1vkg]], [[3f07]] - hHDAC8 + amide derivative<br />
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[[1t69]] - hHDAC8 + SAHA<br />
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**[[1t69]] - hHDAC8 + SAHA<br />
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[[3mz3]] - hHDAC8 (Co) + amide derivative<br />
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**[[3mz3]] - hHDAC8 (Co) + amide derivative<br />
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[[3mz7]] - hHDAC8 (Co) (mutant) + amide derivative<br />
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**[[3mz7]] - hHDAC8 (Co) (mutant) + amide derivative<br />
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[[3mz4]] - hHDAC8 (Mn) (mutant) + amide derivative<br />
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**[[3mz4]] - hHDAC8 (Mn) (mutant) + amide derivative<br />
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[[3mz6]] - hHDAC8 (Fe) (mutant) + amide derivative<br />
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**[[3mz6]] - hHDAC8 (Fe) (mutant) + amide derivative<br />
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[[2v5x]] - hHDAC8 (mutant) + octanediamide derivative<br />
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**[[2v5x]] - hHDAC8 (mutant) + octanediamide derivative<br />
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[[2v5w]] – hHDAC8 + tripeptide<br />
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**[[2v5w]] – hHDAC8 + tripeptide<br />
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[[3ewf]] - hHDAC8 (mutant) + polypeptide<br />
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**[[3ewf]] - hHDAC8 (mutant) + polypeptide<br />
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[[3rqd]] - hHDAC8 + largazole<br />
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**[[3rqd]] - hHDAC8 + largazole<br />
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[[4bz5]] – SmHDAC8 – ''Schistosoma mansoni''<br />
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**[[4bz5]] – SmHDAC8 – ''Schistosoma mansoni''<br />
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[[4bz7]], [[4bz8]], [[4bz9]] – SmHDAC8 + inhibitor<br />
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**[[4bz7]], [[4bz8]], [[4bz9]] – SmHDAC8 + inhibitor<br />
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[[4bz6]] – SmHDAC8 + SAHA<br />
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**[[4bz6]] – SmHDAC8 + SAHA<br />
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===HDAC class IIA===
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*'''HDAC class IIA'''
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''HDAC4''
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*HDAC4
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[[2h8n]] – hHDAC4 N terminal <br />
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**[[2h8n]] – hHDAC4 N terminal <br />
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[[2o94]] - hHDAC4 N terminal (mutant)<br />
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**[[2o94]] - hHDAC4 N terminal (mutant)<br />
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[[2vqw]] - hHDAC4 catalytic domain (mutant)<br />
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**[[2vqw]] - hHDAC4 catalytic domain (mutant)<br />
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[[2vqj]], [[2vqm]], [[4cbt]] – hHDAC4 catalytic domain + inhibitor<br />
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**[[2vqj]], [[2vqm]], [[4cbt]] – hHDAC4 catalytic domain + inhibitor<br />
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[[2vqo]], [[2vqq]], [[2vqv]], [[4cby]] – hHDAC4 catalytic domain (mutant) + inhibitor
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**[[2vqo]], [[2vqq]], [[2vqv]], [[4cby]] – hHDAC4 catalytic domain (mutant) + inhibitor
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''HDAC7''
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*HDAC7
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[[3c0y]] – hHDAC7 catalytic domain<br />
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**[[3c0y]] – hHDAC7 catalytic domain<br />
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[[3c0z]] - hHDAC7 catalytic domain + octanedioic acid hydroxyamide phenylamide<br />
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**[[3c0z]] - hHDAC7 catalytic domain + octanedioic acid hydroxyamide phenylamide<br />
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[[3c10]] - hHDAC7 catalytic domain + trichostatin A<br />
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**[[3c10]] - hHDAC7 catalytic domain + trichostatin A<br />
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[[3znr]], [[3zns]] - hHDAC7 catalytic domain + inhibitor<br />
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**[[3znr]], [[3zns]] - hHDAC7 catalytic domain + inhibitor<br />
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''HDAC9''
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*HDAC9
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[[1tqe]] – mHDAC9 + myocyte-specific enhancer factor + DNA – mouse
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**[[1tqe]] – mHDAC9 + myocyte-specific enhancer factor + DNA – mouse
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''HDAC''
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*HDAC
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[[4a6q]], [[4a90]] - hHDAC subunit SAP18 <br />
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**[[4a6q]], [[4a90]] - hHDAC subunit SAP18 <br />
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[[2hde]] – hHDAC subunit SAP18 (mutant) – NMR<br />
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**[[2hde]] – hHDAC subunit SAP18 (mutant) – NMR<br />
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[[4a8x]] - hHDAC subunit SAP18 + RNA-binding protein + hook-like<br />
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**[[4a8x]] - hHDAC subunit SAP18 + RNA-binding protein + hook-like<br />
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[[2kdp]] – hHDAC subunit SAP30 – NMR<br />
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**[[2kdp]] – hHDAC subunit SAP30 – NMR<br />
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[[2ld7]] – hHDAC subunit SAP30 +SIN3A PAH 3 domain – NMR<br />
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**[[2ld7]] – hHDAC subunit SAP30 +SIN3A PAH 3 domain – NMR<br />
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===HDAC class IIB===
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*'''HDAC class IIB'''
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''HDAC6''
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*HDAC6
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[[3c5k]] – hHDAC6 zinc finger domain<br />
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**[[3c5k]] – hHDAC6 zinc finger domain<br />
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[[3gv4]] - hHDAC6 zinc finger domain + ubiquitin peptide<br />
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**[[3gv4]] - hHDAC6 zinc finger domain + ubiquitin peptide<br />
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[[3phd]] - hHDAC6 + polyubiquitin
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**[[3phd]] - hHDAC6 + polyubiquitin
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===HDAC class III===
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*'''HDAC class III'''
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''Sir2''
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*Sir2
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[[2hjh]] – yHDAC Sir2 - yeast<br />
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**[[2hjh]] – yHDAC Sir2 - yeast<br />
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[[4iao]] – yHDAC Sir2 + Sir4<br />
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**[[4iao]] – yHDAC Sir2 + Sir4<br />
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}}
[[Category:Topic Page]]
[[Category:Topic Page]]

Revision as of 09:58, 27 November 2014

Template:STRUCTURE 3ewf

Histone deacetylase (HDAC) catalyzes the removal of acetyl group from ε-N-acetyl lysine in histones. HDAC contains Zn. DNA expression is regulated by acetylation and de-acetylation. HDAC are classified according to their domain organization to 4 classes. SAHA is a common inhibitor of HDAC. For additional details see

3D Structures of histone deacetylase

Updated on 27-November-2014

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky, Joel L. Sussman

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