Inosine monophosphate dehydrogenase

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== Structural highlights ==
== Structural highlights ==
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</StructureSection>
==3D structures of inosine monophosphate dehydrogenase==
==3D structures of inosine monophosphate dehydrogenase==
Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
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{{#tree:id=OrganizedByTopic|openlevels=0|
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===IMPDH===
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*IMPDH
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[[1ak5]] – TfIMPDH – ''Tritrichomonas foetus'' <br />
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**[[1ak5]] – TfIMPDH – ''Tritrichomonas foetus'' <br />
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[[1eep]] – IMPDH – ''Borellia burgdorferi'' <br />
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**[[1eep]] – IMPDH – ''Borellia burgdorferi'' <br />
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[[1zfj]] – IMPDH catalytic domain – ''Streptococcus pyogenes'' <br />
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**[[1zfj]] – IMPDH catalytic domain – ''Streptococcus pyogenes'' <br />
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[[1vrd]] – IMPDH – ''Thermotoga maritima'' <br />
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**[[1vrd]] – IMPDH – ''Thermotoga maritima'' <br />
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[[3ffs]] – CpIMPDH – ''Cryptosporidium parvum''<br />
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**[[3ffs]] – CpIMPDH – ''Cryptosporidium parvum''<br />
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[[3r2g]] – IMPDH – ''Legionella pneumophila'' <br />
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**[[3r2g]] – IMPDH – ''Legionella pneumophila'' <br />
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[[3tsb]], [[4mjm]] – BaIMPDH (mutant) – ''Bacillus anthracis'' <br />
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**[[3tsb]], [[4mjm]] – BaIMPDH (mutant) – ''Bacillus anthracis'' <br />
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[[4fez]] – VcIMPDH – ''Vibrio cholerae'' <br />
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**[[4fez]] – VcIMPDH – ''Vibrio cholerae'' <br />
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[[4avf]], [[3zfh]] – PaIMPDH – ''Pseudomonas aeruginosa'' <br />
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**[[4avf]], [[3zfh]] – PaIMPDH – ''Pseudomonas aeruginosa'' <br />
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*IMPDH binary complex
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===IMPDH binary complex===
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**[[1me8]] – TfIMPDH + ribavirin monophosphate <br />
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**[[1pvn]] – TfIMPDH catalytic domain + transition state analog <br />
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**[[1me9]] – TfIMPDH + inosinic acid <br />
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**[[2cu0]] – IMPDH + xanthosine monophosphate – ''Pyrococcus horikoshii''<br />
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**[[3tsd]] – BaIMPDH (mutant) + xanthosine monophosphate <br />
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**[[3usb]] – BaIMPDH + inosinic acid <br />
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**[[4ix2]] – VcIMPDH + inosinic acid <br />
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**[[4dqw]] – PaIMPDH + ATP <br />
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[[1me8]] – TfIMPDH + ribavirin monophosphate <br />
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*IMPDH ternary complex
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[[1pvn]] – TfIMPDH catalytic domain + transition state analog <br />
+
-
[[1me9]] – TfIMPDH + inosinic acid <br />
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-
[[2cu0]] – IMPDH + xanthosine monophosphate – ''Pyrococcus horikoshii''<br />
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-
[[3tsd]] – BaIMPDH (mutant) + xanthosine monophosphate <br />
+
-
[[3usb]] – BaIMPDH + inosinic acid <br />
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-
[[4ix2]] – VcIMPDH + inosinic acid <br />
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-
[[4dqw]] – PaIMPDH + ATP <br />
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===IMPDH ternary complex===
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[[1me7]] – TfIMPDH + ribavirin monophosphate + mycophenolic acid <br />
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[[1lrt]] – TfIMPDH + adenine derivative + inosinic acid <br />
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[[1meh]] – TfIMPDH + mycophenolic acid + inosinic acid <br />
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[[1mei]] – TfIMPDH + mycophenolic acid + xanthosine monophosphate <br />
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[[1mew]] – TfIMPDH + NAD + xanthosine monophosphate <br />
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[[3khj]] – CpIMPDH + inhibitor + inosinic acid <br />
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[[4fo4]], [[4fxs]] – VcIMPDH + mycophenolic acid + inosinic acid <br />
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[[4hlv]] – VcIMPDH + NAD + inosinic acid <br />
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[[4ixh]] – CpIMPDH catalytic domain + benzoxazole inhibitor + inosinic acid <br />
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[[4my8]] – BaIMPDH catalytic domain (mutant) + benzoxazole inhibitor + inosinic acid <br />
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[[4my1]], [[4mya]], [[4mxs]], [[4my9]] – BaIMPDH catalytic domain (mutant) + inhibitor + inosinic acid <br />
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[[4mz1]] – IMPDH catalytic domain (mutant) + inhibitor + inosinic acid – ''Campylobacter jejuni''<br />
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[[4af0]] – IMPDH + mycophenolic acid + inosinic acid – ''Cryptococcus neoformans''<br />
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 +
**[[1me7]] – TfIMPDH + ribavirin monophosphate + mycophenolic acid <br />
 +
**[[1lrt]] – TfIMPDH + adenine derivative + inosinic acid <br />
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**[[1meh]] – TfIMPDH + mycophenolic acid + inosinic acid <br />
 +
**[[1mei]] – TfIMPDH + mycophenolic acid + xanthosine monophosphate <br />
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**[[1mew]] – TfIMPDH + NAD + xanthosine monophosphate <br />
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**[[3khj]] – CpIMPDH + inhibitor + inosinic acid <br />
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**[[4fo4]], [[4fxs]] – VcIMPDH + mycophenolic acid + inosinic acid <br />
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**[[4hlv]] – VcIMPDH + NAD + inosinic acid <br />
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**[[4ixh]] – CpIMPDH catalytic domain + benzoxazole inhibitor + inosinic acid <br />
 +
**[[4my8]] – BaIMPDH catalytic domain (mutant) + benzoxazole inhibitor + inosinic acid <br />
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**[[4my1]], [[4mya]], [[4mxs]], [[4my9]] – BaIMPDH catalytic domain (mutant) + inhibitor + inosinic acid <br />
 +
**[[4mz1]] – IMPDH catalytic domain (mutant) + inhibitor + inosinic acid – ''Campylobacter jejuni''<br />
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**[[4af0]] – IMPDH + mycophenolic acid + inosinic acid – ''Cryptococcus neoformans''<br />
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}}
== References ==
== References ==
<references/>
<references/>
[[Category:Topic Page]]
[[Category:Topic Page]]

Revision as of 11:16, 27 November 2014

Structure of IMPDH complex with inosinic acid, K+ (purple) and the inhibitor mycophenolic acid (PDB code 4fo4).

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3D structures of inosine monophosphate dehydrogenase

Updated on 27-November-2014

References

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky

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