Lactate Dehydrogenase

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<StructureSection load='' size='450' side='right' scene='Lactate_Dehydrogenase/Cv/5' caption='Lactate dehydrogenase dimer complex with cofactor NAD and pyruvate (PDB code [[2fm3]])'>
<StructureSection load='' size='450' side='right' scene='Lactate_Dehydrogenase/Cv/5' caption='Lactate dehydrogenase dimer complex with cofactor NAD and pyruvate (PDB code [[2fm3]])'>
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Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
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{{#tree:id=OrganizedByTopic|openlevels=0|
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===L-LDH===
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*L-LDH
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+
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[[2e37]], [[2v6m]] – TtL-LDH – ''Thermus thermophilus''<BR />
+
-
[[2xxe]], [[3zzn]], [[4a73]]– TtL-LDH (mutant) <BR />
+
-
[[2x8l]], [[1ceq]] – PfL-LDH – ''Plasmodium falciparum''<BR />
+
-
[[2zqy]], [[2zqz]], [[1llc]] – LcL-LDH – ''Lactobacillus casei''<BR />
+
-
[[3vku]] - LcL-LDH (mutant)<br />
+
-
[[3d0o]] - SaL-LDH – ''Staphylococcus aureus''<BR />
+
-
[[2v65]] - L-LDH A chain – ''Champsocephalus gunnari''<BR />
+
-
[[2v6b]] – L-LDH – ''Deinococcus radiodurans''<BR />
+
-
[[2frm]] – CpLDH – ''Cryptosporidium parvum''<BR />
+
-
[[1sov]], [[1pze]] - TgL-LDH – ''Toxoplasma gondii''<BR />
+
-
[[1v6a]] – L-LDH A chain – ''Cyprinus carpio''<BR />
+
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[[1y6j]] – L-LDH – ''Clostridium thermocellum''<BR />
+
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[[1ldb]] - GsL-LDH – ''Geobacillus stearothermophilus''<BR />
+
-
[[1ldm]], [[6ldh]], [[8ldh]] – sdM4-LDH – spiny dogfish<BR />
+
-
[[2ldx]] – C4-LDH - mouse<br />
+
-
[[4m1q]] - BseL-LDH – ''Bacillus selenitireducens''<br />
+
-
[[3pqe]] – BsL-LDH (mutant) – ''Bacillus subtilis''<br />
+
-
[[4lmr]], [[4ln1]] - LDH – ''Bacillus cereus''<br />
+
-
[[3vpg]] – TcLDH – ''Thermus caldophilus''<br />
+
-
===L-LDH from yeast (cytochrome b2)===
+
**[[2e37]], [[2v6m]] – TtL-LDH – ''Thermus thermophilus''<BR />
 +
**[[2xxe]], [[3zzn]], [[4a73]]– TtL-LDH (mutant) <BR />
 +
**[[2x8l]], [[1ceq]] – PfL-LDH – ''Plasmodium falciparum''<BR />
 +
**[[2zqy]], [[2zqz]], [[1llc]] – LcL-LDH – ''Lactobacillus casei''<BR />
 +
**[[3vku]] - LcL-LDH (mutant)<br />
 +
**[[3d0o]] - SaL-LDH – ''Staphylococcus aureus''<BR />
 +
**[[2v65]] - L-LDH A chain – ''Champsocephalus gunnari''<BR />
 +
**[[2v6b]] – L-LDH – ''Deinococcus radiodurans''<BR />
 +
**[[2frm]] – CpLDH – ''Cryptosporidium parvum''<BR />
 +
**[[1sov]], [[1pze]] - TgL-LDH – ''Toxoplasma gondii''<BR />
 +
**[[1v6a]] – L-LDH A chain – ''Cyprinus carpio''<BR />
 +
**[[1y6j]] – L-LDH – ''Clostridium thermocellum''<BR />
 +
**[[1ldb]] - GsL-LDH – ''Geobacillus stearothermophilus''<BR />
 +
**[[1ldm]], [[6ldh]], [[8ldh]] – sdM4-LDH – spiny dogfish<BR />
 +
**[[2ldx]] – C4-LDH - mouse<br />
 +
**[[4m1q]] - BseL-LDH – ''Bacillus selenitireducens''<br />
 +
**[[3pqe]] – BsL-LDH (mutant) – ''Bacillus subtilis''<br />
 +
**[[4lmr]], [[4ln1]] - LDH – ''Bacillus cereus''<br />
 +
**[[3vpg]] – TcLDH – ''Thermus caldophilus''<br />
-
[[1kbj]] - LDH FMN-binding domain <br />
+
*L-LDH from yeast (cytochrome b2)
-
[[1sze]], [[1lco]], [[2oz0]] - LDH FMN-binding domain (mutant) <br />
+
-
[[1kbi]] - LDH FMN-binding domain + pyruvate<br />
+
-
[[1szf]], [[1ldc]] - LDH FMN-binding domain (mutant) + pyruvate<br />
+
-
[[1szg]] - LDH FMN-binding domain + sulfo-FMN<br />
+
-
[[3ks0]] - LDH residues 86-180 + flavocytochrome b2 heme domain + FAB B2B4
+
-
''L-LDH binary complex''
+
**[[1kbj]] - LDH FMN-binding domain <br />
 +
**[[1sze]], [[1lco]], [[2oz0]] - LDH FMN-binding domain (mutant) <br />
 +
**[[1kbi]] - LDH FMN-binding domain + pyruvate<br />
 +
**[[1szf]], [[1ldc]] - LDH FMN-binding domain (mutant) + pyruvate<br />
 +
**[[1szg]] - LDH FMN-binding domain + sulfo-FMN<br />
 +
**[[3ks0]] - LDH residues 86-180 + flavocytochrome b2 heme domain + FAB B2B4
-
[[2ydn]], [[4b7u]] – PfL-LDH + bicine<BR />
+
*''L-LDH binary complex''
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[[1cet]] - PfL-LDH + chloroquine<BR />
+
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[[1t2c]] - PfL-LDH + NAD<BR />
+
-
[[3zh2]] - PfL-LDH + DNA aptamer<br />
+
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[[1ez4]] - L-LDH + NAD – ''Lactobacillus pentosus''<BR />
+
-
[[1lld]], [[2ldb]] - GsL-LDH + NAD<BR />
+
-
[[2a92]] – PvL-LDH + NAD – ''Plasmodium vivax'' <BR />
+
-
[[2a94]], [[2aa3]] - PvL-LDH + NAD-analog<br />
+
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[[1u4o]], [[1u4s]], [[1u5a]], [[1xiv]] – PfL-LDH + inhibitor<BR />
+
-
[[2xxb]] – TtL-LDH (mutant) + AMP<br />
+
-
[[3pqf]] – BsL-LDH (mutant) + NAD<br />
+
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[[3vkv]] - LcLDH + fructose-bisphosphate<br />
+
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[[3vpf]] – LcLDH (mutant) + pyruvate<br />
+
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[[4aj1]], [[4aj2]], [[4aj4]], [[4aje]], [[4ajh]], [[4aji]], [[4ajj]], [[4ajk]], [[4ajl]], [[4ajn]], [[4ajo]], [[4al4]] – LDH α chain + inhibitor – rat<br />
+
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[[4ajp]], [[4m49]] – hLDH α chain + inhibitor - human<br />
+
-
[[4i8x]], [[4i9h]], [[4i9n]], [[4i9u]] – rLDH A chain + pyridine derivative - rabbit<br />
+
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''L-LDH ternary complex with inhibitor''
+
**[[2ydn]], [[4b7u]] – PfL-LDH + bicine<BR />
 +
**[[1cet]] - PfL-LDH + chloroquine<BR />
 +
**[[1t2c]] - PfL-LDH + NAD<BR />
 +
**[[3zh2]] - PfL-LDH + DNA aptamer<br />
 +
**[[1ez4]] - L-LDH + NAD – ''Lactobacillus pentosus''<BR />
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**[[1lld]], [[2ldb]] - GsL-LDH + NAD<BR />
 +
**[[2a92]] – PvL-LDH + NAD – ''Plasmodium vivax'' <BR />
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**[[2a94]], [[2aa3]] - PvL-LDH + NAD-analog<br />
 +
**[[1u4o]], [[1u4s]], [[1u5a]], [[1xiv]] – PfL-LDH + inhibitor<BR />
 +
**[[2xxb]] – TtL-LDH (mutant) + AMP<br />
 +
**[[3pqf]] – BsL-LDH (mutant) + NAD<br />
 +
**[[3vkv]] - LcLDH + fructose-bisphosphate<br />
 +
**[[3vpf]] – LcLDH (mutant) + pyruvate<br />
 +
**[[4aj1]], [[4aj2]], [[4aj4]], [[4aje]], [[4ajh]], [[4aji]], [[4ajj]], [[4ajk]], [[4ajl]], [[4ajn]], [[4ajo]], [[4al4]] – LDH α chain + inhibitor – rat<br />
 +
**[[4ajp]], [[4m49]] – hLDH α chain + inhibitor - human<br />
 +
**[[4i8x]], [[4i9h]], [[4i9n]], [[4i9u]] – rLDH A chain + pyridine derivative - rabbit<br />
-
[[1u5c]] - PfL-LDH + inhibitor + NAD<BR />
+
*''L-LDH ternary complex with inhibitor''
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[[1t24]], [[1t25]], [[1t26]] - PfL-LDH + azole derivative + NAD<BR />
+
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[[1t2e]] - PfL-LDH (mutant) + oxamate + NAD<BR />
+
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[[1ldg]] - PfL-LDH + oxamate + NAD<BR />
+
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[[2xxj]] – TtL-LDH (mutant) + oxamate + NAD<BR />
+
-
[[2v7p]] - TtL-LDH + oxamate + NAD<BR />
+
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[[3om9]], [[3czm]] – TgL-LDH + OXQ + NAD<BR />
+
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[[3h3f]] – rL-LDH A chain + oxamate + NAD <BR />
+
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[[2fnz]] - CpLDH + oxamate + NAD<BR />
+
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[[1t2f]] - hL-LDH B chain + azole derivative + NAD <BR />
+
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[[1i0z]] - hL-LDH H chain + oxamate + NAD<BR />
+
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[[1i10]] - hL-LDH M chain + oxamate + NAD<BR />
+
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[[4jnk]] - hL-LDH A chain + inhibitor + lactate + NAD<br />
+
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[[3vph]] - TcLDH + oxamate + NAD + fructose diphosphate<br />
+
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[[1oc4]] – L-LDH + oxamate + NAD – ''Plasmodium berghei''<BR />
+
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[[1a5z]] - L-LDH + oxamate + NAD – ''Thermotoga maritim''a<BR />
+
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[[1lth]] - L-LDH + oxamate + NAD – ''Bifidobacterium longum''<BR />
+
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[[1ldn]] - GsL-LDH + oxamate + NAD<BR />
+
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[[9ldb]], [[9ldt]] - pL-LDH + oxamate + NAD – pig
+
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''L-LDH ternary complex with reactants''
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**[[1u5c]] - PfL-LDH + inhibitor + NAD<BR />
 +
**[[1t24]], [[1t25]], [[1t26]] - PfL-LDH + azole derivative + NAD<BR />
 +
**[[1t2e]] - PfL-LDH (mutant) + oxamate + NAD<BR />
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**[[1ldg]] - PfL-LDH + oxamate + NAD<BR />
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**[[2xxj]] – TtL-LDH (mutant) + oxamate + NAD<BR />
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**[[2v7p]] - TtL-LDH + oxamate + NAD<BR />
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**[[3om9]], [[3czm]] – TgL-LDH + OXQ + NAD<BR />
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**[[3h3f]] – rL-LDH A chain + oxamate + NAD <BR />
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**[[2fnz]] - CpLDH + oxamate + NAD<BR />
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**[[1t2f]] - hL-LDH B chain + azole derivative + NAD <BR />
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**[[1i0z]] - hL-LDH H chain + oxamate + NAD<BR />
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**[[1i10]] - hL-LDH M chain + oxamate + NAD<BR />
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**[[4jnk]] - hL-LDH A chain + inhibitor + lactate + NAD<br />
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**[[3vph]] - TcLDH + oxamate + NAD + fructose diphosphate<br />
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**[[1oc4]] – L-LDH + oxamate + NAD – ''Plasmodium berghei''<BR />
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**[[1a5z]] - L-LDH + oxamate + NAD – ''Thermotoga maritim''a<BR />
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**[[1lth]] - L-LDH + oxamate + NAD – ''Bifidobacterium longum''<BR />
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**[[1ldn]] - GsL-LDH + oxamate + NAD<BR />
 +
**[[9ldb]], [[9ldt]] - pL-LDH + oxamate + NAD – pig
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[[1sow]], [[1pzh]] - TgL-LDH + oxalate + NAD<BR />
+
*''L-LDH ternary complex with reactants''
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[[1t2d]] - PfL-LDH + oxalate + NAD<BR />
+
-
[[1pzf]] - TgL-LDH + oxalate + NAD-analog<br />
+
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[[1pzg]] - TgL-LDH + sulfate + NAD-analog<br />
+
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[[3h3j]] – SaL-LDH (mutant) + pyruvate + NAD<BR />
+
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[[3d4p]] - SaL-LDH + pyruvate + NAD<BR />
+
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[[2fn7]] - CpLDH + lactate + NAD<BR />
+
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[[2ewd]] - CpLDH + pyruvate + NAD-analog<br />
+
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[[2fm3]] - CpLDH + pyruvate + NAD<BR />
+
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[[5ldh]] - pLDH + citrate + NAD-analog<br />
+
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[[3ldh]] - sdLDH + pyruvate + NAD<BR />
+
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[[3pqd]] - BsLDH + fructose-bisphosphate + NAD
+
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===D-LDH===
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**[[1sow]], [[1pzh]] - TgL-LDH + oxalate + NAD<BR />
 +
**[[1t2d]] - PfL-LDH + oxalate + NAD<BR />
 +
**[[1pzf]] - TgL-LDH + oxalate + NAD-analog<br />
 +
**[[1pzg]] - TgL-LDH + sulfate + NAD-analog<br />
 +
**[[3h3j]] – SaL-LDH (mutant) + pyruvate + NAD<BR />
 +
**[[3d4p]] - SaL-LDH + pyruvate + NAD<BR />
 +
**[[2fn7]] - CpLDH + lactate + NAD<BR />
 +
**[[2ewd]] - CpLDH + pyruvate + NAD-analog<br />
 +
**[[2fm3]] - CpLDH + pyruvate + NAD<BR />
 +
**[[5ldh]] - pLDH + citrate + NAD-analog<br />
 +
**[[3ldh]] - sdLDH + pyruvate + NAD<BR />
 +
**[[3pqd]] - BsLDH + fructose-bisphosphate + NAD
-
[[3kb6]] – D-LDH + lactate + NAD – ''Aquifex aeolicus''<BR />
+
*D-LDH
-
[[1j49]] – LdD-LDH + sulfate + NAD – ''Lactobacillus delbrueckii''<BR />
+
-
[[1j4a]] - LdD-LDH + sulfate<BR />
+
-
[[1f0x]] – EcD-LDH + FAD – ''Escherichia coli''<BR />
+
-
[[2dld]] - D-LDH + oxamate + NAD – ''Lactobacillus helveticus''
+
-
===L-LDH II===
+
**[[3kb6]] – D-LDH + lactate + NAD – ''Aquifex aeolicus''<BR />
 +
**[[1j49]] – LdD-LDH + sulfate + NAD – ''Lactobacillus delbrueckii''<BR />
 +
**[[1j4a]] - LdD-LDH + sulfate<BR />
 +
**[[1f0x]] – EcD-LDH + FAD – ''Escherichia coli''<BR />
 +
**[[2dld]] - D-LDH + oxamate + NAD – ''Lactobacillus helveticus''
-
[[1x0a]], [[1vbi]] – TtL-LDH II
+
*L-LDH II
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===L-Lactate/malate dehydrogenase===
+
**[[1x0a]], [[1vbi]] – TtL-LDH II
-
[[1hye]], [[1hyg]] – L-LDH/MDH – ''Methanocaldococcus jannaschi''<br />
+
*L-Lactate/malate dehydrogenase
-
[[2g8y]] - EcL-LDH/MDH
+
 +
**[[1hye]], [[1hyg]] – L-LDH/MDH – ''Methanocaldococcus jannaschi''<br />
 +
**[[2g8y]] - EcL-LDH/MDH
 +
}}
==Additional Information==
==Additional Information==
For additional information, see [[Carbohydrate Metabolism]]<br />
For additional information, see [[Carbohydrate Metabolism]]<br />

Revision as of 11:58, 30 November 2014

Lactate dehydrogenase dimer complex with cofactor NAD and pyruvate (PDB code 2fm3)

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3D structures of lactate dehydrogenase

Updated on 30-November-2014

Additional Information

For additional information, see Carbohydrate Metabolism

Reference

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