Lysine-specific histone demethylase

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Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
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{{#tree:id=OrganizedByTopic|openlevels=0|
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[[2com]], [[2l3d]] - hLSD1 SWIRM domain – human – NMR<br />
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*lysine-specific histone demethylase 1
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[[2h94]], [[2dw4]], [[2z3y]], [[2z5u]], [[4fwe]], [[4fwj]], [[4gu1]] – hLSD1<br />
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[[2hko]] – hLSD1 (mutant)<br />
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[[2ejr]], [[3abt]], [[3abu]] – hLSD1 + tranylcypromine derivative<br />
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[[4fwf]] – hLSD1 + histone 3.1 peptide<br />
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[[4gu0]] – hLSD1 + histone 3.3 peptide<br />
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[[4gur]], [[4gus]], [[4hsu]] – hLSD1 + histone 3.3 peptide + oxidoreductase<br />
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[[4gut]], [[4guu]] – hLSD1 + oxidoreductase<br />
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===LSD1 complex with CoREST===
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**[[2com]], [[2l3d]] - hLSD1 SWIRM domain – human – NMR<br />
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**[[2h94]], [[2dw4]], [[2z3y]], [[2z5u]], [[4fwe]], [[4fwj]], [[4gu1]] – hLSD1<br />
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**[[2hko]] – hLSD1 (mutant)<br />
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**[[2ejr]], [[3abt]], [[3abu]] – hLSD1 + tranylcypromine derivative<br />
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**[[4fwf]] – hLSD1 + histone 3.1 peptide<br />
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**[[4gu0]] – hLSD1 + histone 3.3 peptide<br />
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**[[4gur]], [[4gus]], [[4hsu]] – hLSD1 + histone 3.3 peptide + oxidoreductase<br />
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**[[4gut]], [[4guu]] – hLSD1 + oxidoreductase<br />
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[[2iw5]], [[2uxn]], [[2uxx]] - hLSD1 SWIRM + amine oxidase domains + CoREST SANT1 and SANT2 domains<br />
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*LSD1 complex with CoREST
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[[2v1d]] - hLSD1 residues 123-852 + CoREST SANT1 and SANT2 domains + histone H3 residues 2-22 (mutant)<br />
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[[2x0l]] - hLSD1 residues 123-852 + CoREST SANT1 and SANT2 domains + histone H3 residues 1-16<br />
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[[2xaf]], [[2xag]], [[2xah]], [[2xaj]], [[2xaq]], [[2xas]] - hLSD1 residues 123-852 + CoREST SANT1 and SANT2 domains + tranylcypromine derivative<br />
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[[2y48]] - hLSD1 residues 123-852 + CoREST SANT1 and SANT2 domains + zinc finger protein SNAIL N terminal<br />
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[[3zms]], [[3zmt]], [[3zmu]], [[3zmv]], [[3zmz]], [[3zn0]], [[3zn1]] - hLSD1 residues 123-852 + CoREST SANT1 and SANT2 domains + zinc finger protein IA-1 peptide <br />
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**[[2iw5]], [[2uxn]], [[2uxx]] - hLSD1 SWIRM + amine oxidase domains + CoREST SANT1 and SANT2 domains<br />
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**[[2v1d]] - hLSD1 residues 123-852 + CoREST SANT1 and SANT2 domains + histone H3 residues 2-22 (mutant)<br />
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**[[2x0l]] - hLSD1 residues 123-852 + CoREST SANT1 and SANT2 domains + histone H3 residues 1-16<br />
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**[[2xaf]], [[2xag]], [[2xah]], [[2xaj]], [[2xaq]], [[2xas]] - hLSD1 residues 123-852 + CoREST SANT1 and SANT2 domains + tranylcypromine derivative<br />
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**[[2y48]] - hLSD1 residues 123-852 + CoREST SANT1 and SANT2 domains + zinc finger protein SNAIL N terminal<br />
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**[[3zms]], [[3zmt]], [[3zmu]], [[3zmv]], [[3zmz]], [[3zn0]], [[3zn1]] - hLSD1 residues 123-852 + CoREST SANT1 and SANT2 domains + zinc finger protein IA-1 peptide <br />
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}}
[[Category:Topic Page]]
[[Category:Topic Page]]

Revision as of 12:48, 30 November 2014

Template:STRUCTURE 2v1d

Lysine-specific histone demethylase 1 (LSD1) is a flavin-dependent oxidase that catalyzes the removal of methyl groups from mono- and dimethylated lysine 4 of histone H3. LSD1 is a nuclear homolog of amine oxidase. It functions as histone demethylase and transcriptional corepressor. LSD1 demethylation occurs via a reaction which produces formaldehyde. LSD1 is a component of transcriptional corepressor complex which also contains CoREST (corepressor of element-1-silencing transcription factor).

3D structures of lysine-specific histone demethylase 1

Updated on 30-November-2014

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky, Joel L. Sussman, Jaime Prilusky

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